Microcytic Anemia Flashcards
Metabolic Demands for Iron
Hgb
Myoglobin
1800-2500mg
300-500mg
Iron storage
0-1000mg
Transit (serum iron)
3mg
Total amount of Iron
3000-4000mg (3-4g)
Peripheral blood smear for iron deficiency anemia will show what?
Hypochromic microcytic
what markers test for iron deficiency anemia?
Iron, TIBC, Transferrin saturation, Ferritin
Ferritin is best marker of iron deficiency (100% specificity)
Systemic Manifestations of Iron Deficiency Anemia
Esophageal webs and strictures
Plummer-Vinson syndrome
Koilonychia
Angular stomatitis
Glossitis
Behavior and neuropsychiatric manifestation of Iron Deficiency Anemia
Restless Leg Syndrome
Pica (pagophagia)
Anaphylaxis is most common with what iron supplementation?
Iron Dextran
Treatment with Iron: Response
Reticulocytosis occurs when?
Initial Increase in Hgb is noted in how long?
Hgb increment is how much in how long?
< 7d
2-3 wk
2g q3 wk
Treatment with Iron: Administration
Oral Iron: given as what?
Each tab of 325mg contains how much iron?
Iron is absorbed best when?
What increases dietary absorption and toxicity?
Regimens of 1-2 tabs in AM work just as well as what?
Ferrous salt (e.g. ferrous sulfate)
65mg
an empty stomach with NO antacids
Ascorbic acid
Split doses throughout the day
Treatment with Iron: IV iron
Use IV iron in place of PO iron if what?
toxicity
noncompliance
iron malabsorption
What is an uncommon cause of Microcytic Anemia?
Lead poisoning
Sources of Lead poisoning include:
Children?
Adults?
All ages?
ingesting lead based paint
industrial sources: inhaling or ingesting
water distribution
Lead Poisoning Hematologic Effects
Impairs synthesis of heme
hemolytic anemia
microcytic anemia refractory to iron therapy
basophilic stippling
Approach to B thalassemia intermediate and major
Screening/counseling
RBC transfusion therapy
hydroxyurea to increase Hgb F
Bone marrow transplantation
Major complications of treatment with RBC transfusions is Iron overload
