GI Bleeding Flashcards

1
Q

Clinical Presentation
Initial evaluation & resuscitation
Assess what? Use what?
Access required?
Lab to obtain for resuscitation?
Monitor what labs?
Transfuse when?
Supplement what electrolyte? why?

A

Assess severity of bleeding; continuous monitoring of HD parameters to guide resuscitation
2 large bore IVs immediately
Type & Cross
CBC, Coags, Ca+
Ca+; citrate in blood products binds with Ca+ leading to hypocalcemia

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2
Q

Estimating Blood Loss
Class I
Loss of how much total blood volume?
Clinical findings include?

A

</= 15%
may be minimal or absent d/t compensation of transcapillary refill

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3
Q

Estimating Blood Loss
Class II
Loss of how much total blood volume?
S/Sx?
Compensatory mechanism activated?
May see drop in what due to what?

A

15-30%
orthostatic changes in HR, BP
vasoconstriction maintains flow to vital organs
UOP; Splanchnic flow

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4
Q

Estimating Blood Loss
Class III
Loss of how much total blood volume?
Onset of what?
S/Sx?

A

30-40%
decompensated hypovolemic shock
hypotension, decreased UOP

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5
Q

Estimating Blood Loss
Class IV
Loss of how much total blood volume?
S/Sx?
Changes may be what?

A

> 40%
hypotension & oliguria more profound (UOP < 5ml/hr)
irreversible

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6
Q

Resuscitation of hypovolemic shock goal

A

maintain DO2 to tissues & sustain aerobic metabolism
Support CO
Correct Hgb deficits

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6
Q

How much IV crystalloid infusion to replace blood loss?
What type to use?
What type of blood to use during resuscitation?

A

3ml/1ml blood loss
LR 1-2L initially
NS (be aware of possible hyperchloremic acidosis)
O-

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7
Q

Transfuse for hgb < what?
Transfuse for Hgb < what for cardiac or ortho surgery?

A

7
8

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8
Q

Hx and Risk Factors for GI Bleeding
elderly?
Younger?
other risk factors?

A

Diverticulosis, vascular ectasia, ischemic colitis
Varices, ulcers, esophagitis
previous bleeding/GI dz, previous surgery, underlying dz

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9
Q

Meds that can cause GI bleeding

A

NSAIDs
ASA

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10
Q

Clinical Findings for GI bleeding

A

Change in bowel habits
Weight loss
Abdominal pain
Hematemesis
Melena
Coffee-ground emesis
Hematochezia
Bloody NG aspirate

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11
Q

Upper GI bleeding is from where?
Endoscopy recommended within what time frame?

A

esophagus, stomach, duodenum
24 hrs

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12
Q

Differential Dx for Upper GI bleeding
Nonvariceal

A

peptic ulcer
Mallory-Weiss tear
Erosive esophagitis or duodenitis
esophagitis
dieulafoy’s lesion
angiodysplasia
malignancy

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13
Q

Differential Dx for Upper GI bleeding
Variceal

A

esophageal
gastric

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14
Q

Clinical Manifestations of Peptic Ulcer Dz
Recurrent pain with periods of remission described how?

A

usually epigastric
may radiate to back
burning
painful hunger
may be relieved by, worsened by, or unrelated to food
nocturnal pain several hrs after late meal c/w ulceration

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15
Q

Clinical Manifestations of Peptic Ulcer Dz

A

heartburn/acid reflux into throat c/w GERD
N/V may be present

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16
Q

Complications of PUD

A

Bleeding, perforation

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17
Q

When to test for H. Pylori?

A

Active PUD
Mucosa associated lymphoid tissue (MALT)
H/o endoscopic resxn of early gastric CA
Uninvestigated dyspepsia if < 60 (without alarm features)
Chronic NSAIDs
Unexplained iron deficiency anemia
ITP

18
Q

Alarm features for H. Pylori?

A

bleeding
anemia
early satiety
unexplained weight loss
progressive dysphagia
recurrent vomiting
family h/o GI CA

19
Q

Mallory-Weiss tears are what?

A

mucosal & possibly submucosal lacerations from sudden increase in pressure in cardia & lower esophagus from vomiting

20
Q

Mallory-Weiss tears
how to stop bleeding?
tears are usually how long and where?

A

usually ceases spontaneously
1.5-2 cm; @ GE junction or proximal stomach

21
Q

Dieulafoy’s lesions
what are they?
Where are they typically located?

A

visible vessel protruding from small mucosal defect no ulceration
in lesser curvature

22
Q

Benign GI Neoplasms

A

GISTs
Carcinoid
lipomas

23
Q

Malignant GI Neoplasms

A

adenoca of esophagus
stomach
duodenum
SCCA of esophagus
gastric or duodenal lymphomas

24
Q

H. Pylori Treatment
Is there a PCN allergy? N
Previous Macrolide exposure for any reason? N
What is the recommended treatment?

A

Bismuth quadruple
CONCOMITANT
Clarithromycin triple with amoxicillin

25
Q

H. Pylori Treatment
Is there a PCN allergy? N
Previous Macrolide exposure for any reason? Y
What is the recommended treatment?

A

Bismuth quadruple
Levofloxacin triple
Levofloxacin sequential

26
Q

H. Pylori Treatment
Is there a PCN allergy? Y
Previous Macrolide exposure for any reason? N
What is the recommended treatment?

A

Clarithromycin triple with metronidazole
Bismuth quadruple

27
Q

H. Pylori Treatment
Is there a PCN allergy? Y
Previous Macrolide exposure for any reason? Y
What is the recommended treatment?

A

Bismuth quadruple

28
Q

Hx found in varices

A

Symptoms of liver dz
family h/o hereditary liver dz (Wilson Dz)
Lifestyle (ETOH, drugs)
PMH - jaundice, prior blood transfusions

29
Q

Exam for varicies

A

signs of bleeding
dyspnea
jaundice
telangiectasia
palmar erhythema if cirrhosis
ascites
distended abd wall veins

30
Q

Risk factors for Stress-Related Mucosal Dz

A

recent major surgery
major trauma
severe burns
TBI
MSOF
MV>48hrs
coagulopathy (plt ct < 50, INR > 1.5, PTT > 2x NL)

31
Q

GI prophylaxis
Level I recs All patients with?
Level II recs ICU patients with what?
Level III recs Injury severity score > what? and what med?

A

MV, coagulopathy, TBI, major burn
multi-trauma, sepsis, acute renal failure
15; high dose steroids (>250mg hydrocortisone/day)

32
Q

GI Prophylaxis preferred agents
Level I recs: no difference b/t what meds? shouldn’t use what?
Level II recs: what meds shouldn’t be used in dialysis patients?
Level III recs: what alone may be insufficient prophylaxis?

A

H2RAs, cytoprotectives & PPI; Antacids
aluminum containing meds
enteral nutrtion

33
Q

GI prophylaxis Duration of therapy
Level I?
Level II?
Level III?

A

none
duration of MV or ICU stay
until able to tolerate enteral nutrition

34
Q

Treatment for Stress-Related Mucosal DZ Upper GI bleed?

A

Endoscopy as in PUD
Surgery for those with uncontrolled hemorrhage; usually vagotomy, oversew, or subtotal/total gastrectomy (rare)

35
Q

Lower GI Bleeding from where?

A

from source distal to ligament of Treitz

36
Q

Risk factors for Lower GI bleeding?

A

Antiplatelets
NSAIDs
P2Y12 inhibitors

37
Q

Diverticular Dz
most common cause of lower GI bleed with up to what % of cases?
More often in who? affecting up to 2/3 of those > what?
~3-15% of those with diverticulosis experience what?
patients experience painless what?
Usually ceases how? but can recur in up to what % of cases?

A

40%
elderly; 80 yrs
bleeding
hematochezia
40%

38
Q

Ischemic Colitis/other Colitis
responsible for what % of LGIBs?
sudden decrease in what?
typical areas of involvement include what areas?
Patients experience what symptoms?
usually resolves how?
Common cause of LGIB in ICU d/t what?
On endoscopy usually appears as what?
severe bleeding from infectious colitis, XRT colitis, and inflammatory bowel dz is what?

A

19%
mesenteric flow; transient and reversible
watershed areas: splenic flexure, rectosigmoid junction, R colon
sudden abd pain, hematochezia w/n 24 hrs
spontaneously w/ support, rarely requires surgery
hemorrhagic nodules, cyanotic or necrotic mucosa with heomrrhagic ulcerations, or abrupt transition b/t injured & normal mucosa
rare

39
Q

Angiodysplasia
Rates of occurrence as source of LGIB vary widely up to what %?
Primarily in what population?
bleeding usually has what characteristics?
On endoscopy lesions are what?

A

37%
elderly
brisk, painless, difficult to distinguish from diverticular bleed
flay & red with vessels extending from central feeding vessel, usually R colon

40
Q

Small bowel sources of LGIBs

A

angiodysplasia
lymphoma
SB ulcers
Crohn’s dz

41
Q

Other sources of LGIBs

A

Hemorrhoids
CA
Post polypectomy
Ulcers
XRT

42
Q

Diagnostic Evaluations include?

A

Colonoscopy
CT angio
Surgery

43
Q

Anticoagulation Guidance in GI Bleed

A

DC NSAIDs (in diverticular bleed)
DC ASA if used for primary CV prevention (Diverticular bleed)
Continue ASA if prior CV dz (diverticular bleed)
resume anticoagulants after cessation of bleeding