Microcytic Anaemia Flashcards
Causes of microcytic anaemia (TAILS)
- thalassemia
- anaemia of chronic disease
- iron deficiency anaemia
- lead poisoning
- sideroblastic anaemia
Causes of normacytic anaemia (3As & 2Hs)
- acute blood loss
- anaemia of chronic disease
- aplastic anaemia
- haemolytic anaemia
- hypothyroidism
Causes of megaloblastic macrocytic anaemia
- B12 deficiency (pernicious anaemia)
- folate deficiency
Underlying pathology of megaloblastic macrocytic anaemia
Impaired DNA synthesis
Causes of non-megaloblastic macrocytic anaemia
- alcohol abuse
- hypothyroidism
- pregnancy
A state that is causes by haemolytic anaemia and blood loss which can lead to non-megaloblastic macrocytic anaemia
Reticulocytosis
Medication that can lead to non-megaloblastic macrocytic anaemia
Azathiopurine
Pathology of pernicious anaemia
Auto Abs against IF that absorbs Vit B12
Diseases that are RFs of microcytic anaemia
- autoimmune thyroid disease
- vitiligo
- T1DM
- Addison’s
In B12 and folate deficiencies which one do you fix first
B12
B12 injection for pernicious anaemia the is given at 2-3m interval
Hydroxocabalamin
How to determine the type of macrocytic anaemia if it’s mega- or non-megaloblastic
Blood smear
