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Y3 Haematology Conditions > Lymphoma > Flashcards

Lymphoma Flashcards

1
Q

Define Hodgkin’s lymphoma

A

Contagious malignant tumour of lymphatic system/spleen

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2
Q

Abnormal B cells that are unique to Hodgkin lymphoma

A

Reed Sternberg cells

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3
Q

Age distribution and peak of Hodgkin’s

A
  • bimodal

- 20 & 75 yo

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4
Q

Best prognosis type of Hodgkin’s

A

Lymphocyte predominant

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5
Q

Worst prognosis type of Hodgkin’s

A

Lymphocyte depleted

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6
Q

Good prognosis type of Hodgkin’s that is associated with a large number of Reed-Sternberg cells

A

Mixed cellularity

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7
Q

Good prognosis type of Hodgkin’s that is common in women and is associated with lacunar cells

A

Nodular sclerosing

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8
Q

Presentation of cervical and supraclavicular lymphadenopathy

A
  • painless
  • rubbery
  • non-tender
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9
Q

Pain in lymph nodes due to Hodgkin’s is worsened by

A

Alcohol

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10
Q

Systemic effects of Hodgkin’s

A
  • night sweats
  • weight loss
  • fever
  • chest problem
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11
Q

Virus that increases the risk of Hodgkin’s

A

EBV

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12
Q

Chemical substance that increases the risk of Hodgkin’s

A

Benzene

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13
Q

Gender more at risk of Hodgkin’s

A

Men

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14
Q

Ann Arbor stage I

A

Single lymph node region

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15
Q

Ann Arbor stage II

A

Two or > node regions. On same side of diaphragm

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16
Q

Ann Arbor stage III

A

Node regions on both sides of diaphragm

17
Q

Ann Arbor stage IV

A

Dissemination to one or more extra lymphatic organs or tissues

18
Q

What are Reed Sternberg cells found in lymph nodes in core needle biopsy

A

Nuclei w/ nucleoli inside them

19
Q

CD changes in core needle biopsy

A

+CD15/CD30

20
Q

Why are low Hb & high LDH (lactate dehydrogenase) not good enough to diagnose lymphoma

A

Not specific

21
Q

FBC findings in hodgkin’s

A
  • anaemia
  • lymphopenia
  • neutrophilia
  • eosinophilia
22
Q

Chemotherapy agents

A
  • adriamycin
  • bleomycin
  • vinblastine
  • darcabazine
23
Q

SEs of chemotherapy

A
  • leukaemia

- infertility

24
Q

SEs of radiotherapy

A
  • hypothyroidism
  • cancer
  • nephrotic syndrome
  • amyloidosis
25
Q

Definition of non-Hodgkin’s

A

Umbrella term for non-lymphoid

26
Q

Differential of Hodgkin’s from non-Hodgkin’s

A

No Reed-Sternberg cells

27
Q

Chemical exposure that increases the risk of non-Hodgkin’s

A

Trichloroethylene

28
Q

Viruses (& bac) that increase the risk of non-Hodgkin’s

A
  • HIV
  • EBV
  • Hep B/C
  • H pylori
29
Q

H pylori in lymphoma is associated with

A

Gastric MALT (mucosa-associated lymphoma tissue)

30
Q

EBV in lymphoma is associated with

A
  • Burkitt’s lymphoma
  • AIDS-related CNS lymphoma
  • malaria
31
Q

Hep C in lymphoma is associated with

A
  • diffuse large B cell lymphoma

- splenic marginal zone lymphoma

32
Q

Human T cell lymphotropic virus type 1 is associated with

A

T-cell lymphoma

33
Q

Diffuse large B cell lymphoma in over 65 is characterised by

A

Rapidly growing

34
Q

Presentation of non-Hodgkin lymphoma

A
  • painless lymphadenopathy
  • symmetrical
  • multiple sites
  • spread discontinuously across nodal sites
35
Q

Systemic and organ-specific symptoms of non-Hodgkin lymphoma

A
  • fever
  • night sweats
  • weight loss
  • splenomegaly
  • hepatomegaly
36
Q

Blood films reveal what in NH lymphoma

A
  • uncleared red cells

- left shift

37
Q

Tx options for NH lymphoma

A
  • chemo/radio
  • stem cell transplant
  • monoclonal Ab (rituximab)

Y3 Haematology Conditions (3 decks)

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