Microbiology

Question 1

How do [Vancomycin Resistant Enterococcus] obtain their resistance to Vancomycin?

Answer 1

Vancomycin normally binds to [D-alanyl-D-alanine terminal in Cell Wall] and inhibits peptidoglycan formation

VRE substitute their [D-alanyl] for [D-LACTATE] –> Vancomycin Resistance!

Question 2

Mechanisms of Acquiring Campylobacter (2)

Answer 2

1. Ingestion of Intestine containing Campy (Chicken/Cows/Unpast Milk)
2. Domestic Animals (Chicken / Dogs / Cows)

Question 3

Which bacteria is most commonly isolated from an intraabdominal abscess (i.e. from appendicitis perforation)? (4)

Answer 3

1. Bacteroides Fragilis = MOST COMMON
2. E.Coli
3. Enterococci
4. Strep

Question 4

Where is [Ribosome RNA] synthesized?

Answer 4

All Ribosome RNA is synthesized in the Nucleolus

• Except [5S rRNA]*
• Ribosome proteins are translated from mRNA in cytoplasm*

Question 5

Which Abx is used in Recurrent C.Diff infection? Route of Admin and MOA

Answer 5

FidaXomicin (Used in Recurrent C.Diff)

PO Macrocylic Abx that inhibts [sigma RNA polymerase subunit] –> Bacteriocidal

Question 6

Identify the organism and list its common manifestations (2)

Answer 6

Scabies

1. Pruritic Rash (worst at night) on flexer surfaces and finger webs
2. Excoriations with crusted red papules

Dx = skin scrapings with mites vs. ova. feces

Question 7

Classic initial Presentation for Dengue Fever (4)

Answer 7

1. Retro-Orbital Pain
2. HA
3. Joint & Muscle Pain
4. Fever

Question 8

Chikungunya Clinical Presentation (3)

Answer 8

1. Polyarthralgias
2. Diffuse Macular Rash
3. Flu-like sx

Question 9

Identify the Dz

Answer 9

Herpes Simplex

On Tzanck Smear