Microbiology 22: Opportunistic Viral Infections Flashcards
Which 2 organisms can cause Infective mononucleosis ?
CMV
EBV
Which genetic mutation gives a predisposition to invasive Herpes simplex encephalitis ?
UNC93B
What type of virus is HIV ?
Lentivirus
Which cells does HIV target ?
CD4+ T cells
Which Virus causes Kaposi Sarcoma ?
HHV8
Which virus causes Burkitss lymphoma in HIV patients ?
EBV
Which infections are people receiving anti -TNF therapy particularly predisposed to ?
Intracellular infections- TB
Can BMT patients receive VZV vaccination ?
No because it is a live virus and they are immunocompromised.
What is the difference in Immunocompromise of solid organ and bone marrow transplant patients ?
BMT patients are the most immunocompromised just before receiving the transplant because their own bone marrow is wiped out. After receiving the transplant a new immune system has to be established from the donors bone marrow.
Solid organ patients are less immunocompromised but then have to suppress their immune system for the rest of their lives.
List different herpes viruses ?
HSV 1 and 2 VZV CMV EBV HHV8 HHV6
Where does VZV lay dormant ?
Dorsal root ganglia
In which cells does CMV lay dormant ?
Monocytes
In which cells does EBV lay dormant ?
B lymphocytes
What is the main treatment for HSV infection ?
Acyclovir
What are 2 treatment/prophylaxis of VZV options for immunocompromised or pregnant women ?
Prophylactic aciclovir
Post-exposure prophylaxis with VZig
Which virus is associated with Progressive leukoencephalopathy ?
JC virus
Which virus causes mouth ulcers in post transplant patients ?
HSV
Which viruses causes a patient to be very unwell and appear septic with high fevers post bone marrow transplant ?
Adenovirus
What is the typical serology of a patient with chronic hepatitis B infection ?
HBs Ag +ve
IgG HBc antibodies +ve
IgM HBc antibodies -ve
HBs antibodies -ve
List 2 things that are caused by EBV in HIV patients ?
oral hairy leukoplakia
lymphomas: Burkitt’s lymphoma, Hodgkin’s
Which disease is caused by EBV in patients post transplant ?
post-transplant lymphoproliferative disorder (PTLD)
Which virus causes graft rejection ?
HHV6
