Histopathology 8: Liver pathology Flashcards
Aspergillus produces …………. which causes hepatocellular carcinoma
Aflatoxin
Which tumour marker indicates hepatocellular carcinoma ?
AFP
List 4 causes of hepatocellular carcinoma ?
- Hepatitis B or C
- Alcoholic cirrhosis
- Haemochromatosis
- Aflatoxin
- NAFLD
Which cancer is caused by liver flukes ?
Cholangiocarcinoma
Which syndrome is associated with cholangiocarcinoma ?
Lynch syndrome type II
What are the macrophages in the liver called ?
Kupffer cells
Where do stellate cells reside in the liver ?
Space of disse
Is alcoholic cirrhosis micronodular or macronodular ?
Micronodular
Is cirrhosis due to viral hepatitis micronodular or macronodular ?
Macronodular
List 3 histological features of alcoholic liver disease ?
- Ballooning
- Mallory denk bodies
- Fibrosis
What causes NAFLD ?
Insulin resistance e.g due to diabetes or obesity
What is the characteristic histological features of PBC ?
Granulomatous destruction of bile ducts secondary to chronic inflammation
Which auto antibody is associated with PBC ?
anti-mitochondrial antibodies
Describe the characteristic histological features of PSC ?
- Periductal bile duct cirrhosis leading to bile duct loss
- “Onion skinning”
Which disease is associated with PSC ?
Ulcerative colitis
Is cirrhosis due to biliary tract disease micronodular or macronodular ?
Micronodular
List 5 genetic causes of liver cirrhosis ?
haemochromatosis wilson's disease alpha 1 antitrypsin deficiency galactosaemia glycogen storage disease
What is the most common benign liver tumour ?
Haemangioma
Which zone in liver lobules is the first to be affected by alcoholic liver disease ?
Zone 3
Which HLA is associated with autoimmune hepatitis ?
HLA-DR3
List 3 auto antibodies seen in autoimmune hepatitis ?
ANA
Anti-SMA
Anti-LKM
ERPC shows beading of bile ducts.
Most likely diagnosis ?
PSC
What is Budd-Chiari syndrome ?
Compression/ Occlusion of the hepatic vein
Which stain is used to identify copper in Wilson’s disease “
Rhodanine stain
What happens to Caeruloplasmin levels in Wilson’s disease ?
They are reduced
Which genetic disease causes both Emphysema and liver cirrhosis ?
Alpha 1 antitrypsin deficiency
Which auto-immune disease is associated with PBC ?
Sjogrens
What is the triad for PBC ?
Jaundice
xanthelasma
pruritus
Give 2 causes of haemosiderosis ?
alcohol
blood transfusions
