Microbial Pathogenesis & Virulence Flashcards
1
Q
Pathogenicity Islands
A
Sections of bacterial chromosome that differs from the rest of surrounding DNA sequences.
- Results in genetic variability
- Obtained through horizontal genetic exchange.
2
Q
Core Genome (Housekeeping Genes)
A
Chromosomal elements that ALL members of a species share and are highly conserved.
3
Q
Variable Elements (Mobile Genetic Elements)
A
Chromosomal elements that are variable between and within species and are virulent.
- Ex. plasmids, pathogenicity islands
4
Q
Viral Adherence of Enveloped Viruses
A
Enveloped Viruses use its glycoproteins on its envelope to attach to host cell receptors.
5
Q
Viral Adherence of Non-Enveloped Viruses
A
Non-enveloped viruses use its capsid’s spike components to attach to host cell receptors.
6
Q
Endotoxin
A
- Non-antigenic toxin produced by Lipid A portion of outer membrane in gram - bacteria.
7
Q
Exotoxin
A
- Pore-forming toxin secreted by some bacteria.
- Has A & B subunits
- Lyses cells like RBCs (Hemolysis)
- Highly antigenic (stimulates antibody production)
