Microanatomy 2 Flashcards
What protein do adherens junctions use and what cytoskeleton is involved?
cadherins, actin microfilament
What protein do focal adhesions use and what cytoskeleton is invovled?
Integrin and actin microfilament
What protein do desmosomes use and what cytoskeleton is involved?
cadherins, intermediate filament
What protein do hemidesmosomes use and what cytoskeleton is involved?
integrins, intermediate filament
How is the cytoskeleton linked to ECM?
Fibronectin connects to integrins which conencts to actin microfilament inside cell.
What are tight junctions and what protein is invovled?
cell-cell adhesion that forms impermeable barrier between apical and basal side, located near apical side of cell. Claudin and occludin proteins hold membranes together.
What molecules are involved in cell cell and cell matrix interactions?
Cadherins (Ca dependent, strong)
immunoglubolin family (Ca indepedent, less strong than cadherin)
Selectins (transient, Ca dependent, rolling blood cells)
MHC (immune system, mediates presentation of foreign protein fragments to B and T cells)
What are platelets derived from?
Myeloid–>megakaryocytes–>release platelets
How are RBCs derived?
Myeloid→erythroblasts→reticulocytes→mature erythrocyte
Reticulocytes has rRNA and produce hemoglobin but no nucleus. relased from bone marrow. Then degrades rRNA to become mature RBC.
How are monocytes made?
Myeloid→monocytes→enter tissue and serous cavities→macrophage
How are plasma cells derived?
Lymphoid→activated B lymphocytes→goes to lymph node→plasma cells (secrete antibodies)
List the formed elements of blood in order of most abundant to least.
Erythrocytes, Platelets (thrombocytes), neutrophil, lymphocyte, monocytes, eosinophil, basophil
Ethan, please never let monkeys eat bananas.
