MICRO: VIROLOGY Flashcards
1
Q
NAKED DNA VIRUSES
A
PAPP PAPILLOMA VIRUS, ADENOVIRUS, PARVOVIRUS POLYOMA VIRUS
2
Q
NAKED RNA VIRUSES
A
C-CALICIVIRUS
P-PICORNA VIRUS
R-REOVIRUS
H-HEPE VIRUS
3
Q
MOST RNA VIRUSES HAVE A HELICAL SYMMETRY EXCEPT
A
PICORNA FLAVI CALICI REO TOGA HEPE
4
Q
ALL DNA VIRUSES ARE ICOSAHEDRAL EXCEPT
A
POXVIRUS
5
Q
MOST RNA VIRUSES HAVE A HELICAL SYMMETRY AND ASSUME A SPHERICAL SHAPE EXCEPT
A
RHABDOVIRUS
6
Q
ALL viruses are halploid except
A
RETROVIRUS
7
Q
VIRUSES WITH SEGMENTED GENOME
A
B bunyaviruses
O orthomyxoviruses (influenza)
A arena virus
R reovirus
8
Q
negative strand RNA viruses
A
always bring polymerase or fail replication
a arenavirus b bunyavirus p paramyxovirus o orthomyxovirus f filovirus r rhabdovirus
9
Q
the only RNA viruses with a double stranded genome
A
reoviridae , (rotavirus)
10
Q
most DNA virsues have both a negative strand and a positive strand except_____ which have single stranded DNA genome
A
parvovirus
11
Q
live attenuated vaccines
A
MISS CRY MMR influenza (intranasal) sabin polio small pox chicken pox rotavirus yellow fever
12
Q
name the receptors of the ff viruses CMV EBV HIV PARVO RABIES RHINOVIRUS
A
CMV- INTEGRINS (HEPARAN SULFATE) EBV CD21 HIV CD4 CCRD CXCR4 PARVO P antigens on RBCs RABIES nicotinic AchR RHINOVIRUS ICAM -1
13
Q
name all DNA viruses
A
HHAPPPPY
hepadna
herpes
adeno
14
Q
all DNA viruses have a double strand except
A
parvovirus
15
Q
all DNA viruses replicate in the nucleus, except
A
poxvirus
16
Q
all RNA viruses replicated in the cytoplasm, except
A
influenza, rotavirus
17
Q
all DNA viruses have linear DNA, except
A
papillomavirus (circular supercoiled)
polyoma virs (circular supercoiled)
hepadnavirus(circular incomplete)
18
Q
aplastic anemia
A
parvovirus
19
Q
acute hemorrhagic cystitis
A
adenovirus
20
Q
progressive multifocal leukoencephalopathy
A
JC virus
21
Q
name members of the papova virus family
A
human papilloma virus
JC virus
BK
22
Q
hemorrhagic cystitis and nephropathy in organ transplant patients
A
BK polyoma virus
23
Q
congenital varicella
what happens if baby is infected at
6-12
16-20
A
6-12 limb, cicatrization
16-20 eyes and brain
24
Q
CMV: CT scan findings
A
periventricular calcifications
25
DOC for the prevention of CMV disease in solid organ transplant patients
valganciclovir
26
DOC for herpes
acyclovir
27
DOC CMV
ganciclovir
28
owl's eye, giant cells
CMV
29
cause of
hairy leukoplakia in AIDS patients
AIDS retinitis in AIDS patients
hairy leukoplakia in AIDS patients- EBV
| AIDS retinitis in AIDS patients-CMV
30
downey cells
EBV
31
CAUSE OF Nasopharyngeal carcinoma in chinese people
EBV
32
DOC molluscum contagiosum
cidofovir
33
extrahepatic manifestations of HBV
membranous glomerulonephritis
| polyarteritis nodosa
34
persistence of what marker for hepa B is the principal marker for developing chornice liver disease and cancdr
HBSAg
35
DOC for influenza virus
oseltamivir
36
antiviral against fusion protein
pavilizumab
37
gold standard in the detection of rabies specific antigen
IFAT
38
receptor for SARS COV virus
angiotensin converting enzyme 2
39
receptor for MERS COV
cd 26
40
main cause of essential mixed cryoglobulinemia
hepa C
41
confirmatory test for hepa C
RIBA- recombinant immunoblot assay
42
describe the clinical course of yellow fever
jaundice
sudden onset of fever
headache, myalgia, photophobia (parang dengue?)
then prostration and shock may occur
accompanied by UPPER GI HEMORRHAGE with hematemesis
43
name the arboviruses
flaviviridae , togaviruses, bunyaviruses
44
most common cause of epidemic encephalitis
japanese B encephalitis
45
HIV coreceptor on macrophage
CCR5
46
CD4 COUNT OF PLHIV: CMV RETINITIS
<20
47
CD4 COUNT OF PLHIV DISSEMINATED TB
<500
48
CD4 COUNT OF PLHIV :PCP
<200
49
CD4 COUNT OF PLHIV: HISTOPLASMOSIS
< 20
50
CD4 COUNT OF PLHIV COCCIDIOMYCOSIS
<200
51
CD4 COUNT OF PLHIV C. PARVUM, CHRONIC DIARRHEA
<200
52
CD4 COUNT OF PLHIV: M.AVIUM INVASIVE PULMONARY DSE
<20
53
CD4 COUNT OF PLHIV TOXOPLASMOSIS
<200
54
CD4 COUNT OF PLHIV COCCIDIOMYCOSIS
<200
55
CD4 COUNT OF PLHIV KAPOSI
<500
56
CD4 COUNT OF PLHIV HSV ESOPHAGITIS
<500
57
CD4 COUNT OF PLHIV ESOPHAGEAL CANDIDIASIS
<500
58
presumptive test for HIV detects? what test
p24, ELISA
59
HIV definitive diagnosis detects what antigens, what test
gp41 or gp120, western blot
60
what is
first disease
second disease
etc.. until 6th disease
```
1measles
2scarletfever
3 rubella
4 Staphylococcal scalded skin syndrome
5 slapped cheek parvovirus b19
6 HHV exanthem subitum
```
61
Most common cause of congenital abnormalities
Cmv
62
Heterophil positive virus
EBV
63
Nagayama spots
Exanthum subitum , sixth disease
64
Differentiate lesions of variola from varicella
Varicella: different stages
Variola: same stages
65
Most common clinical form of polio
Abortive poliomyelitis
Febrile illness with headache sore throat n/v
66
Infection caused by coxackie a
Herpangina
67
Coxackie b
Pleurodynia
68
Hand foot and mouth dse
Herpangina
69
Orphan virus
ECHO virus
70
Members of the picornaviridae
```
Polio
Coxackie
Echo
Rhino
Hep a
```
71
Influenza causing pandemics
Influenza a
72
Major outbreak of influenza
Inf B
73
Most important antigen for influenza
Hemagglutinin
74
Attach and release mechanism
| Of influenza
Hemagglutin for attachment
Neuraminidase for release
75
Reassortment of genes
Mutations
Which one is Major , minor?
Major: reassortment
Minor: mutation
Reassortment: shift: pandemic
Mutation: drift : epidemic
76
Causes of reye’s syndrome
Influenza
| Chicken pox
77
Warthin finkeldey bodies
Measles
78
Top three causes of viral meningitis
Coxackie
Mumps
Measles
79
Most important cause of pneumonia and bronchiolitis in infants
RSV
80
Seal like cough
Parainfluenza
81
Follows acute neurologic phase of rabies no matter what the presentation
Coma
82
Vector for dengue
Aedes
83
Associated with a hypervariable region in the envelope glycoprotein
Hep C
84
Has mir122
Hep c
85
Most common indicAtion for liver transplantAtion
Chronic hcv infection
86
Vector for zika
Aedes
87
Vector for jap en
Culex
88
Ct scan finding common in jap en
Thalamic infarcts
89
Most characteristic feature is post auricular LAD
Rubella
90
Organs affected by CMV
Brain : mental retardation and sensorineural deafness
Heart PDA
Eyes CATARACT
91
Genes of HIV that are REQUIRED for relication
Tat
Rev
ReTa!!!! Rekta lols
92
Gp 120 And gp41 are encoded by?
Env
Envelope
Gp41 and gp120 are found in the envelope
93
Decreases CD4 proteins and class I MHC Proteins
Nef
Vif
Vpr
Vpu
Nec
94
Induces death of uninfected cytotoxic t cells
Nef
Vif
Vpr
Vpu
Nef
95
Enhances infectivity of HIV
Vif
96
Transporters viral core from cytoplasm into nucleus in non dividing cells
Nef
Vif
Vpr
Vpu
Vpr
Think: transporter
Transprtr
VPr
97
Gene that enhances release of viron from cells
Nef
Vif
Vpr
Vpu
Vpu
Pupu release
98
Enhances infectivity of HIV
Nef
Vif
Vpr
Vpu
Vif
Vif
Ifectivity😂
99
Transports late mRNA from nucleus to cytoplasm
Rev
100
Receptor for early infection of HIV
CD4?
CCR5?
CXCR4?
Early: CCR5 seen in macrophages
101
Late HIV infection receptor
Implicated
CCR5
CXCR4
CD4
CXCR4
Seen in lymphocytes
102
Targeted by maraviroc HIV drug
CCR5
Maraviroc
This receptor seen in macrophages
103
TAARGETED BY MARAVIROC
CCR5
CCR5 seen in Macrophage targeted by Maraviroc
Both start with Ma
104
Also target by the HIV virus
Is a mediator for mucosal immunity
TH1
TH2
TH21
TH17
Th17
105
Main immune response against HIV
Cd8 cytotoxic cells
106
When will HIV patients be expected to test positive
Phase of seroconversion
| Where they present with flu like symptoms
107
CD4 count of AIDS
<200
108
Test that detects viral load of HIV
PCR
