Micro HYPERSENSITIVUTY Flashcards
Immediate or anaphylactic
Type 1
Ig-E mediated
Type 1
Occur within Minute after re exposure
Type 1
Anaphylactic or immediate type
Mos immunogenicity subs in type 1
Protein
High affinity receptors
FceR1
FCeR1 Component?
Basophil and mast cells
Low affinity receptors ; surface of B cells
FCeR2
What type of hypersensitivity, that T cells control the response to inhalant antigens
Type 1
IgE production depends on what cell
Th2
Stimulate class switching
Th2
Response on first exposure stimulating
Th1
Other Ig that stimulated by TH2
IgG
Form TH2
IL-4
Has anti inflammatory response
IL-13
Activate eosinophils
IL-5
Enchance IgE Prod and stimulate mucus
IL-13
What triggers the release of CHEMOKINES
Th2
Mast cells
Epithelial cells
Bronchial asthma
Hay fever
Chronic rhinitis
Venoms
Aspergillus - fungi
Drugs and food
Type 1
Urticaria
Type 1
Vasodilation, vascular leakage and smooth muscle spasm or glandular secretion occur, what phase
Immediate phase
Vasodilation, vascular leakage and smooth muscle spasm or glandular secretion occur, what phase
Immediate phase
Subside in few hours (5-30mins)
Immediate rxn
No additional exposure to antigen
Late phase
Infiltration of tissues with eosinophils, neutrophil, basophil and cd4
Late phase rxn
There is mucosal damage
Late phase rxn
Vasoactive amines
Histamine