MICRO 7

Question 1

The finding of “sclerotic bodies” described as copper pennies in biopsy material is associated with which of the following fungal infections?

A. Blastomycosis
B. Chromomycosis
C. Sprorotrichosis
D. Eumycetoma

Answer 1

B. Chromomycosis

Question 2

The most common mycotic pulmonary infection is caused by which of the following?

A. Pneumocystis spp.
B. Rhizopus spp.
C. Histoplasma capsulatum
D. Aspergillus fumigatus

Answer 2

C. Histoplasma capsulatum

Question 3

Hortaea wernickii is the causative agent of which of the following?

A. Tinea manus
B. Madura foot
C. Black piedra
D. Chromoblastomycosis

Answer 3

A. Tinea manus

Question 4

TRUE statements of pityriasis versicolor include which of the following?

A. The infection elicits a granulomatous inflammatory response in the skin
B. Causative agent is a dematiaceous fungi
C. Selenium sulfide is not part of the treatment protocol
D. Scrapings of the lesion is described microscopically as “spaghetti and meatball” appearance

Answer 4

D. Scrapings of the lesion is described microscopically as “spaghetti and meatball” appearance

Question 5

The presence of spherules containing several endospores in tissue samples taken from the lung is a pathognomonic lesion of a fungal infection caused by which of the following?

A. Coccioides immitis
B. Blastomyces dermatitis
C. Paracococcioides brasilliensis
D. Histoplasmosis capsulatum

Answer 5

A. Coccioides immitis

Question 6

All of the following disease entities are considered systemic fungal infections with the exception of

A. blastomycosis
B. mucormycosis
C. paracoccidiodomycosis
D. histoplasmosis

Answer 6

B. mucormycosis

Question 7

Which if the following is an opportunistic mycosis characterized by a predilection of hyphal elements to invade blood vessels causing thrombosis, infarction, and massive tissue necrosis?

A. Zygomycosis
B. Aspergillosis
C. Candidiasis
D. Cryptococcosis

Answer 7

A. Zygomycosis

Question 8

What is the term applied to fungal infections characterized by the presence of darkly pigmented septate hyphae in tissues?

A. Phaeohyphomycosis
B. Sprorotrichosis
C. Mycetoma
D. Chromoblastomycosis

Answer 8

A. Phaeohyphomycosis

Question 9

Desert Rheumatism:

A. Blastomycosis
B. Paracoccidioidomycosis
C. Histoplasmosis
D. Coccidioidomycosis

Answer 9

D. Coccidioidomycosis

Question 10

San Valley fever

A. Blastomycosis
B. Paracoccidioidomycosis
C. Histoplasmosis
D. Coccidioidomycosis

Answer 10

D. Coccidioidomycosis

Question 11

Gilchrist’s disease:

A. Blastomycosis
B. Paracoccidioidomycosis
C. Histoplasmosis
D. Coccidioidomycosis

Answer 11

A. Blastomycosis

Question 12

South American blastomycosis:

A. Blastomycosis
B. Paracoccidioidomycosis
C. Histoplasmosis
D. Coccidioidomycosis

Answer 12

B. Paracoccidioidomycosis

Question 13

Which of the following fungal diseases is/are caused by the so-called “black molds”?

1. Chromoblastomycosis
2. Phaeohyphomycosis
3. Maduromycosis
4. Aspergillosis

Answer 13

1. Chromoblastomycosis
2. Phaeohyphomycosis
3. Maduromycosis

Question 14

Which of the following statements regarding Pneumocystis jiroveci is/are correct?

1. No known reservoir is demonstrated
2. The cyst form is the infective stage
3. It does not cause disease in the absence of immunosuppression
4. Itraconazole is the drug of choice

Answer 14

1. No known reservoir is demonstrated
2. The cyst form is the infective stage
3. It does not cause disease in the absence of immunosuppression

Question 15

A 28-year old florist had her finger pricked while pruning rose bushes. This leads to formation of localized pustule that becomes an ulcerated lesion. Few days later, nodules began to appear in her wrist and proximal arm. Tissue biopsy would most likely reveal which of the following?

1. Presence of asteroid body
2. A granulomatous inflammation
3. Fusiform yeast cells
4. Caseous necrosis

Answer 15

1. Presence of asteroid body
2. A granulomatous inflammation
3. Fusiform yeast cells

Question 16

The presence of spherules containing several endospores in tissue samples taken from the lung is a pathognomonic lesion of a fungal infection caused by which of the following?

A. Coccioides immitis
B. Blastomyces dermatitis
C. Paracoccidioides brasiliensis
D. Histoplasmosis capsulatum

Answer 16

A. Coccioides immitis

Question 17

Which of the following statements associated with cutaneous mycoses is CORRECT?

A. Zoophilic dermatophytes are easiest to identify because they produce the greatest number of conidia
B. The location of choice to obtain specimen for diagnosis is at the center of the lesion where hyphal growth is most robust
C. Lesions are somewhat worse with anthropophilic fungi as they produce the most number of irritants
D. Clinical forms are based on site of involvement

Answer 17

D. Clinical forms are based on site of involvement

Question 18

Which of the following is an opportunistic mycosis characterized by a predilection of hyphal elements to invade blood vessels causing thrombosis, infarction, and massive tissue necrosis?

A. Zygomycosis
B. Cryptococcosis
C. Aspergillosis
D. Candidiasis

Answer 18

A. Zygomycosis

Question 19

An impoverished 51-year old farmer was examined by a newly licensed freshly deployed doctor to the barrios. Patient exhibit swelling in his right foot with an oozing wound draining dark red to black granules. He confessed the condition developed 2 months after he step on something hard barefooted while preparing his land for the next planting season. It caused a tear on his heel which, until the time of consult, the wound has not fully healed. You sent tissues for biopsy and culture studies to a university hospital 1 hour away by car. 2 weeks later a classmate of yours in medical school working in the said medical facility sent a picture of the etiologic agent via your FB messenger without divulging the rest of the microbiologic report Which anti-fungal drug would be the best suited for his condition?

A. Ketoconazole
B. Nystatin
C. Flucytosine
D. Miconazole

Answer 19

A. Ketoconazole

Question 20

Which of the following thermally dimorphic fungi is NOT associated with endemicity and an airborne mode of inoculation?

A. Paracoccidioides brasiliensis
B. Coccioides immitis
C. Sporothrix schenckii
D. Blastomycosis dermatitis

Answer 20

C. Sporothrix schenckii

Question 21

A 10-year old child undergoing chemotherapy for acute leukemia began to complain about recurring headaches, stiff neck, and disorientation. CSF taken from a lumbar puncture reveal presence of encapsulated unicellular yeast cells on negative staining. The causative agent is best classified as a:

A. Deuteromycete
B. Ascomycete
C. Basidiomycete
D. Zygomycete

Answer 21

C. Basidiomycete

Question 22

Which of the following is/are considered systemic fungal infection/s?

1. Histoplasmosis
2. Blastomycosis
3. Paracoccidioidomycosis
4. Mucormycosis

Answer 22

1. Histoplasmosis
2. Blastomycosis
3. Paracoccidioidomycosis

Question 23

The 4 primary systemic mycoses have the following characteristics in common:

1. Infections are initiated first in the lungs
2. Causative agents are dimorphic fungi
3. Geographically restricted to specific areas of endemicity

Answer 23

1. Infections are initiated first in the lungs
2. Causative agents are dimorphic fungi
3. Geographically restricted to specific areas of endemicity

Question 24

Which of the following is not a dermatophyte

A. Microsporum
B. Trichosporum
C. Trichophyton
D. Epidermophyton

Answer 24

B. Trichosporum

Question 25

Which is true of maduromycosis? A. Granule color does not have relevance in determining the causative agent B. Pathology is characterized by formation of hyaline cartilage C. It is an occupational hazard of barefoot farm laborers D. It does not involve deep tissues like coniguous muscles & bone

Answer 25

C. It is an occupational hazard of barefoot farm laborers

Question 26

Which systemic mycosis is characterized by spherules containing endospores? A. Coccidiomycosis B. Histoplasmosis C. Blastomycosis D. Paracoccidiomycosis

Answer 26

A. Coccidiomycosis

Question 27

What is the major clinical form of zygomycosis A. Rhinocerebral B. Periorbital C. Thoracic D. Cardioembolic

Answer 27

A. Rhinocerebral

Question 28

Aflatoxin is a carcinogenic mycotoxin which causes the following carcinoma A. Squamous cell carcinoma B. Bronchogenic carcinoma C. Hepatocellular carcinoma D. Renal cell carcinoma

Answer 28

C. Hepatocellular carcinoma

Question 29

Which of the following fungal diseases is NOT caused by the so called “black dots”? A. Maduromycosis B. Chromoblastomycosis C. Aspergillosis D. Phaeohyphomycosis

Answer 29

C. Aspergillosis

Question 30

Presence of yeast resembling “Mariner’s Wheel” is a characteristic of which fungal infection? A. Histoplasma capsulatum B. Coccioides imitis C. Blastomycosis D. Paracoccidiodes

Answer 30

D. Paracoccidiodes

Question 31

Which of the following is INCORRECT regarding fungi? A. Cell wall of fungi contains sterols, while the bacteria has murein B. Dimorphic feature is temperature dependent C. It evokes granulomatous inflammation D. Taxonomic classification is based on its anamorphic state

Answer 31

D. Taxonomic classification is based on its anamorphic state

Question 32

Systemic mycoses are characterized by the following EXCEPT: A. all are caused by a dimorphic fungus B. all are exogenous infections C. all are acquired by ingestion of conidia D. all have areas of endemicity

Answer 32

C. all are acquired by ingestion of conidia

Question 33

What is the most common disseminated form of fungal infection? A. Mucormycosis B. Candidiasis C. Cryptococcosis D. Histoplasmosis

Answer 33

B. Candidiasis

Question 34

What is the main clinical manifestation of invasive Aspergillus? A. Meningoencephalitis B. Pneumonia C. Ulcerative mucocutaneous lesion D. Septicemia

Answer 34

B. Pneumonia

Question 35

Pneumocystis infection is best described in humans as: A. chronic diarrhea in debilitated B. fungemia in AIDS and cancer px C. pneumonia in immunocompromised D. meningoencephalitis in elderly

Answer 35

C. pneumonia in immunocompromised