Micro Flashcards
Downy cells
seen in EBV pts
- EBV infects B cells, atypical lymphocytes on smear (Tc responding to infxn)
- basophilic w/ foamy cytoplasm
Owl eye inclusions
CMV infection- infects mononuclear cells
can cause pneumonia in transplant pts and can cause esophagitis ( fluconazole non improved pts) OR retinitis ( blindness in days) both in AIDS pts
spindle cells–what type of herpes
kaposi sarcoma
- infects endothelial cells
- vascular tumors
- GI/lungs too
- sexually transmitted
- higher rates in immunocompromised (transplant, HIV/AIDS, MsM)
tx: HAART
heterophile test
EBV
aggultination of sheep and horse rbcs
monospot test
heterophile - mono: CMV OR acute HIV
pharyngitis tx w/ amoxcilling–>full body rash after 1st dose
aminopencillin
NOT ALLERGY
foscarnet
2nd line tx for A resistant HSV OR G resistant CMV retinitis in immunocompromised
- more toxic, pyrophosphate analog (does not need to be in infected cell to be activated)
- can lead to nephrotoxicity, anemia
Gancylvoir SE
nephrotoxicity, BM suppression
increase Cr, drop in CBC #’s
Tznack test used for
HSV1,2, or VZV
looking for mulitnucleated giant cells in vesciles
-not sensitive OR specific
Cowdry inclusions are seen in
cells infected with HSV1,2 OR VZV
increased risk of Burkitts lymphoma, Hodgkins lymphoma, 1 CNS lymphoma in AIDs pts, nasopharyngeal carcinoma
EBV
DNA viruses typical characteristics
- dsDNA (except parvoB19)
- linear (except papilloma, polymavirus [JC], hepadnaB [partially circular]
- icosahedral EXCEPT pox
- replicated in nucleus EXCEPT pox
- those that are enveloped derived from PM EXCEPT herpes
hpv strains–
normal warts:
genital warts:
cancer:
1,2
6,11
16,18
I went to a retro toga party where i drank flavored corona and ate hippy california pickles
retrovirus, toga virus, flavivirus, corona virus, hepe virus, calicvirus, picornavirus
+ssRNA viruses
give PAPP smears and CPR to all hippes
naked viruses:
DNA viruses–PAPP–papilloma, polyma, adeno, pox
RNA viruses– calci, pico, reo, hepe
diarrheal illness that spreads during winter months in daycares
REO virus:
- rotavirus
- dsRNA
- naked virus
- vomiting, diarrea–>electrolyte disturbances
Colorado tick fever
REO virus
-coltivirus
meningitis in the summer
echovirus (picornavirus family, enterovirus) w/ feco-oral spread
can infect anterior horn of SC
west nile virus (1/150 who develop neurologic symptoms)
picorna–entero–polio
common causes of the cold
corona, rhino
Cruise ship gasteroenteritis
Norwalk (Calicivirus)
bone break fever
Dengue -torniquet test (low plt) -retrooribtal pain -sever muscle pain \+ hemmorhagic fever (< 20%)
ritonavir
Protease inhibitor
SE of drug class:
- lipodystrophy (buffalo hump, central obesity)
- increased TG, glu, lipids
avoid giving pts rifampin b/c it decreases the concentration of these drugs
drug specific SE:
- inhibits CYP450
- pancreatitis
ataznavir
PI
- increases bilirubin–> jaundice
- also can cause nephrolithasis
indinavir
MOA of drug
PI
neprothiasis
MOA–prevents maturation of viral progeny
ZDV
NRTIs
- used at delivery and for neonate to decrease transmission
- SE: bone marrow suppression and megaloblastic anemia
abacvair
MOA
NRTIs
MOA–CI of RT, requires P by Thymidine kinase in order to be active
SE:life threatening hypersen rxn
didanosine
NRTI
SE
-pancreatitis
-hepatic steatosis
stavudine
NRTI
hepatic steatosis
EFavirenz, MOA
NNRT
- NC RT inhibitor, no p for activation required
- false + for MJ on tox, vivid dreams, worsening depression
- teratogen
Raltegravir
integrase inhibitor
enfuvirtide
inhibits gp41 (viral fusion protein) preventing viruses from invading cells
maraviroc
binds to gp120 receptor on CCR5
can only be given to pts with CCR5 ONLY tropism!!
