Micellanious

Question 1

Which Vitamin?

Hydroxylation of proline & lysine (collagen syn)

Answer 1

C (Ascorbic acid)

*Def = scurvy (perifollicular hemorrhage, gingivitis, m. pain)

Question 2

Which Vitamin?

Isomerase & methytransferase cofactor (DNA & methionine syn)

Answer 2

B12 (cobalamin)

*Def = megaloblastic anemia, neurologic deficits

Question 3

Which Vitamin?

Hydroxymethyl/formyl carrier (purine & thymine syn)

Answer 3

B9 (folate)

*megaloblastic anemia, neural tube defects (fetus)

Question 4

Which Vitamin?

carboxylase rxn (CO2 carrier)

Answer 4

B7 (biotin)

*dermatitis, conjunctivitis, alopecia, neurologic changes

Question 5

Which Vitamin?

transamination of AAs (AA syn)

Answer 5

B6 (Pyridoxine)

*peripheral neuropathy, cheilosis, stomatitis, glossitis

Question 6

Which Vitamin?

Acetylation rxn (CoA)

Answer 6

B5 (Pantothenic acid)

*distal paresthesia (rare)

Question 7

Which Vitamin?

redox rxn (NAD/NADP)

Answer 7

niacin (B3)

*Pellagra (dermatitis, dementia, diarrhea)

Question 8

Which Vitamin?

mito redox rxn (FMN, FAD)

Answer 8

B2 (Riboflavin)

*Cheilosis, stomatitis, glossitis, normocytic anemia

Question 9

Which Vitamin?

Decarboxylation of a-keto acids (carbohydrate meta)

Answer 9

B1 (thiamine)

*beriberi (peripheral neuropathy, HF), wernicke-korsakoff syndrome.

Question 10

Hageman factor (factor XII)

Answer 10

secondary hemostasis: activate intrinsic clotting pathway + activate fibrinolysis.

*syn by liver and activated by exposed collagen following damage to endothelial cells.

Question 11

Kallikrein fx

Answer 11

convert kininogen to bradykinin (vasodilation, inflammation, plasma extravasation, bronchoconstriction, nociception)

Question 12

accum of abn ubiquitinated TAR DNA-binding protein-43 (TDP-43)

Answer 12

amyotrophic lateral sclerosis (sleep difficulty, inability to change position d/t m weakness, pain d/t m. cramps, comorbid anxiety)
frontotemporal dementia

*abn fx of txn inh and DNA repair protein.