Immunology

Question 1

IL-5 function

Answer 1

Stimulates B cells&raquo_space; proliferate and generate IgA

*Produced by activated CD4 cells and mast cells

Question 2

N-formylated peptides function?

Answer 2

recruit neutrophils to areas of active infection

*Released by damaged host cells and pathogens

Question 3

RANTES chemokine function?

Answer 3

recruits T cells, eosinophils, basophils to area of inflammation

Question 4

What type of hypersensitivity?

rxn 7-10 days after exposure

Answer 4

type III

*APC process&raquo_space; displace HMC II&raquo_space; CD4 bind&raquo_space; activate/sti B cells&raquo_space; form plasma cells&raquo_space; Secrete high affinity IgG&raquo_space; IgG binds foreign protein&raquo_space; generate immune complexes (ICs)&raquo_space; classical complement cascade

Question 5

Function in classical complement cascade:

C3b

Answer 5

opsonizing protein C3b = allow IC to be cleared by phagocytic cells using C3b Rs

Question 6

Function in classical complement cascade:

C3a & C5a

Answer 6

anaphylatoxins = potent chemoattractants = incr phagocyte recruitment (neutrophils/macrophages) to areas of IC deposition&raquo_space; vasodilation/ incr permeability
» dev local and systemic inflammatory manifestations
*resolve spon over a few days