MHS Flashcards
Extraversion
Disposition to be outgoing, risk taking and cheerful.
Neuroticism
Disposition to experience more negative feelings and low self esteem
Openness
Disposition to be curious and interested in novel and unconventional things
Agreeable
Disposition to be caring and modest
Conscientiousness
Disposition to be organised, ambitious and dependable.
Empathy
Understand patients situations, perspective and communicate that understanding, check its accuracy and act upon it.
Locus of control
Perspective of who controls ones destiny.
What does WHO define health as?
A complete state of wellbeing
Health inequality
Difference in health status of individuals and groups
Health inequity
Unfair differences that are potentially avoidable
What did the Marmot review show?
Proportionate universalism: disadvantages start before birth and accumulate throughout life. Therefore action reqd. Before birth.
What does the black report say?
Main cause of health inequalities is economic inequality. Death rate for social class V men 2x that of class 1
What does the Acheson report show?
Inequalities between social classes. Mortality decreases across all Cl asses, but is decreasing faster in higher social classes.
Whitehall report
CVD prevalence and mortality rates in male civil servants (cohort study). Lower grade had higher rates than highest.
Examples of simple Mendelian diseases?
Huntingdon’s, CF, DMD
What is simple Mendelian inheritance?
100% correlation between geno and phenotype.
What is polygenic inheritance?
Small number of genes contribute most of the genetic risk.
Example of polygenic disease?
Alzheimer’s
Complex inheritance
Both genetic and environment factors. Dysfunction of one isn’t enough.
Autosomal recessive
2 unaffected carrier parents- 1 in 4 chance of child being affected. If one parent is affected then child has 1 in 2. E.g. Sickle cell anaemia
Autosomal dominant
Familial hypercholesterolaemia.
X linked recessive
Usually only men affected. Females Re usually asymptomatic carriers. 50% of sons affected, 50% daughters carriers. All daughters of affected men are carriers and sons unaffected.
DMD, haemophilia A, red-green colourblind
What is an RCT?
Gold standard, test efficacy of various interventions on a populations. Assessment for eligibility before treatment begins and group is randomly allocated to treatment or control –> bias eliminated
Cohort study
Longitudinal study with analysis of risk factors. Follows a group of people who don’t have the disease. Can be split or 2 separate groups. Determines correlation between cause and effect