Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PRE-REG own > MHRA ALERTS > Flashcards

MHRA ALERTS Flashcards

1
Q

What is the MHRA alert for ondansetron

A

Risk of cleft palate in 1st trimester of pregnancy and not to be useed, report to MHRA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are 2 MHRA alerts for corticosteroids

A
  1. risk of central serous choroiretinopathy - visual

2. need for steroid emergency card to support early recognition of adrenal crisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the MHRA alert for topical CCS

A

risk of TSW after long term use - rebound flare, intense redness, sting etc beyond initial area
e.g. in 2 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is the MHRA warning regarding hydrocortisone granules Alkindi

A

RIsk of acute adrenal insufficiency in children when switching from crushed tab to granules due to inaccurate dosing -monitor for tiredness, vomiting, unstable temp. floppy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the MHRA warning regarding montelukast

A

neuropsychiatric rxn and obsessive compulsive symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what does MHRA advise for adrenaline autoinjectors

A

always carry 2

check expiry dates and obtain replacements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are MHRA alerts regarding SGLT2 inhibitors

A
  1. risk of DKA atypical with only moderately elevated BG, have monitoring of ketones during treatment interruption in surgery or acute medical illness
  2. fourniers gangrene
  3. cana=lower limb amputation risk
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the MHRA warning for haloperidol

A

Risk of neurological and cardiac effects when treating patients with delium - only use if benefits/risks
(NOTE MHRA alert for pts with dementia small increased risk of stroke when given antipsychotics)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is MHRA warnring for clozapine

A

Risk of intestinal obstruction/paralyticileus - seek advice before next dose if constipation develops

and monitoring blood concs of clozapine for toxicity is now advised in certain situations e.g. infection, stopping smoking etc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is MHRA advice regarding levothyroxine

A

if experience sx with different products maintain on same manufacturer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is MHRA alert for PEG laxatives

A

Addition of PEG laxatives (e.g. movicol, macrogol - osmotic) to liquids that have been thickened with starch based thickener may counteract the thickening action and thus pts with dysphagia will be at risk of aspiration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is MHRA alert regarding gabapentin and pregabalin

A

Resp depression

now CD3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is MHRA alert regarding SSRIs

A

Risk of post partum haemorrhage when used in month before delivery in pregnancy - benefit Vs risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is MHRA alert regarding ulipristal acetate (esmya) when used for uterine fibroids

A

Risk of liver injury

ONLY for intermittent treatment mod/severe before menopause when surgery failed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is MHRA alert regarding miconazole

A

NOT w warfarin-inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is MHRA alert regarding warfarin

A
  1. Calciphylaxis -painful skin rash

2. with hep C drugs - changes to INR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is MHRA alert regarding yellow fever vaccine

A

live vaccine so stronger precuations in people with reduced immunity and >60

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is MHRA alert regarding simvastatin 80mg

A

High risk of myopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is MHRA alert regarding statins

A

interstitial lung disease- report SOB, cough, weight loss

20
Q

What is MHRA alert regarding DOACs

A
  1. c/i in bleeds risk
  2. risk of thrombosis in ptss with antiphospholipid syndome-warfarin preferred
  3. not in mitral valve
21
Q

What is MHRA alert regarding lidocaine teething products

A

Only under supervision of pharmacist when other non pharm have been tried and failed (teething rings. rubbing gums etc)
Only pea sized blob, repeated after3. hours
No more than 6x day

22
Q

What is MHRA alert regarding domperidone

A

risk of QT prolongation- CV risk factors and ECG

23
Q

What is MHRA alert regarding citalopram

A

interaction with cocaine-illicit drug us

24
Q

What is MHRA alert regarding etoricoxib

A

lower dose of 60mg daily in RA/SPA (cardiac risk)

25
Q

What is MHRA alert regarding finasteride

A

reports of depression & suicidal thoughts in men taking 1mg for hair loss

Also women of childbearing age not handling crushed/broken ttabs

26
Q

What is MHRA alert regarding loperamide

A

QT prolongation in high dose loperamide >16mg a day

27
Q

What is MHRA alert regarding PPIs

A

low risk of SLE on sun exposed areas accompanied by arthralgia -scaly plaques and lesions

28
Q

What is MHRA alert regarding quinine

A

dose dependent QT prolongation

29
Q

What is MHRA alert regarding hydrochlorothiazideWhat is MHRA alert regarding

A

risk of non melanoma skin cancer esp long term

30
Q

What is MHRA alert regarding carbimazole

A
  1. congential malformations and strengthened advice on contraception
  2. acute pancreatitis
31
Q

What is MHRA alert regarding isotretinoin

A
  • erectile dysfunction and reduced libido
  • also teratogenic
  • psychiatric reactions and depression
  • women of childbearing to be ON PPP
32
Q

What is MHRA alert regarding sodium valproate

A

NOT in any other indication of women of childbearing age unless epilepsy and others ineffective - PPP needed and risk acknowledgment forms

33
Q

What is MHRA alert regarding nexplanon (contraception implant)

A

Neurovascular injury and migration to pulmonary artery - check for movement

34
Q

What is MHRA alert regarding BZs and opioids

A

risk potentially fatal resp depression

ONLY prescribe BZ and opioids together if there is no other alternative

35
Q

What is MHRA alert regarding cyproterone actetate

A

Risk of meningioma

36
Q

What is MHRA alert regarding use of stimulant laxatives

A

pack size restrictions and ages
ONLY using stimulant laxatives if other laxatives are ineffective (BF and osmtic)= laxatives also are not 1st line, second line after diet/lifestyle
-CHILDREN <12 should not use stimulant laxatives without advice from prescriber
- >12 under pharmacist advice
- large packs aren’t available in GSL outlets, only as Pharmacy medicines
- only smaller packs are on GSL (2x short - 20 caps standard )

37
Q

What is MHRA alert regarding DENOSUMAB 60mg (osteoporosis dose)

A

Multiple vertebral fractures risk esp when stopping

high risk if previous fractures

38
Q

What is MHRA alert regarding emollients

A

risk of severe and fatal burns

- all emollients (not just paraffin)

39
Q

What is MHRA alert regarding fentanyl patches

A

NOT used in opioid naive patients

very high risk of resp depression - only used in non cancer patients who have previously tolerated opioids

use other analgesia first

40
Q

What is MHRA alert regarding insulins

A

risk of cutaneous amyloidosis at injection site for all insulins which may affect glycaemic control
rotate inj sites to reduce risk of this and lipodystrophy

41
Q

What is MHRA alert regarding fluorouracil

A

if patients have DPD deficiency can cause toxicity- test before initiation

42
Q

What is MHRA alert regarding modafinil

A

Risk of congenital mlaformations in pregnancy - avoid in pregnancy and for childbearing women- use contraception during and 2 months after

43
Q

What is MHRA alert regarding Bupropion (zyban) for smoking cessation

A

serotonin syndrome risk when used with SSRIs etc

44
Q

What is MHRA alert regarding fluoroquinolones

A

heart valve regurgitation - SOB, swelling ankles/abdomen, palpitations

45
Q

What is MHRA alert regarding varenicline(champix)

A

suicidal thoughts

PRE-REG own (35 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions