Metronidazole Flashcards
1
Q
Metronidazole
A
- **Bacteriocidal **
- anaerobic infections and pseudomembranous colitits (C diff)
- MOA = bacterial nitroreductase (in anaerobic conditions) forms radical reduction products
- disrupts DNA and other macromolecs by forming covalent bonds
- **hepatic metabolism **
- **can inhibit P450 **
- adverse effects =
- **disulfiram-like rxn **when EtOH is consumed (N/V)
- dry mouth, **metallic taste **
- **urine may be dark reddish brown **
- resistance = reduced lvls of nitroreductase
