Cell wall inhibitors: Beta Lactam ABX - Carbapenems

Question 1

Imipenem-cilastatin

Answer 1

• **Bacteriocidal **
• broadest activity of all ABX
• **highly resistant to inactivation **
• not absorbed PO
• **renal excretion **
• Cilastatin (prevents brkdwn from renal enzyme)
• adverse effects:
  
  • cross allergenicity w/ other Beta Lactams
  • **seizures **(up to 1.5%)
• same mechanism of action as PCNs

Question 2

Meropenem

Answer 2

• carbapenem
• like Imipenem-cilastation but doesnt need cilastatin