Anti-TB Drugs: MDR TB - Bedaquiline

Question 1

Bedaquiline

Answer 1

• MOA = **targets ATP synthase in mycobacterium **
• PO
• **hepatic metabolism (P450s) **
  
  • ​DONT administer w/ CYP3A inducers (ie Rifampin)
• ​adverse effects =
  
  • increases hepatic transaminases (monitor LFTs)
  • **BLACK BOX WARNING **( increased risk of death, QT prolongation )