Methylxanthines

Question 1

KT: alkaloids

Answer 1

group of alkaline substances taken from plants, which react w/ acids to form salts

Question 2

KT: methylxanthines

Answer 2

chemical group of drugs derived from xanthines

Question 3

KT: phosphodiesterase (PDE)

Answer 3

group of enzymes that change intracellular signaling

Question 4

KT: xanthine

Answer 4

nitrogenous compound found in many organs and in the blood and urine

Question 5

Uncontrolled asthma

Answer 5

asthma more than 2x a week requiring medication

Question 6

Clinical Indications for Use of Xanthines…

Answer 6

Asthma (Theophylline)
COPD (Theophylline: recommended as an alternative to β2 agonist & anticholinergic)
Apnea of Prematurity: first line treatment, Theophylline most often used, caffeine citrate may be better choice

Question 7

Serum levels of Theophylline

Answer 7

No effects seen: 20 mcg/mL
Cardiac arrythmias: >30 mcg/mL
Seizures: 40-45 mcg/mL

Question 8

Theophylline

Answer 8

Slo-Phyllin, Theolair, Quibron, Bronkodyl, Theo-dur

Question 9

Aminophylline

Answer 9

Aminophylline

Question 10

Serum level of theophylline to treat asthma

Answer 10

5-15 mcg/mL

Question 11

Serum level of theophyliine to treat COPD

Answer 11

10-12 mcg/mL