Methylprednisolone Flashcards
1
Q
What is the trade name?
A
Solu-Medrol
2
Q
What is its class?
A
Glucocorticoid
3
Q
What is its mechanism of action?
A
- suppresses acute and chronic inflammation
- potentiates smooth muscle relaxation by beta adrenergic agonists and may alter airway hyperactivity
4
Q
Onset
A
1-2 hours
5
Q
Duration
A
8-24 hours
6
Q
Indications
A
- Anaphylaxis
- bronchodilator-unresponsive asthma
- shock (controversial)
- adrenal insufficiency
7
Q
Contraindications
A
Use with caution with GI bleeding, diabetes mellitus, or severe infection
8
Q
Adverse reactions
A
- headache
- hypertension
- sodium and water retention
- alkalosis
- hypokalemia
9
Q
Drug interactions
A
- hypoglycemic responses to insulin and oral hypoglycemic agents may be blunted
- potassium-depleting agents may potentiate hypokalemia induced corticosteroids
10
Q
Adult dose
A
2mg/kg up to 125mg IV
or 40-125 mg IV
11
Q
Pediatric dose
A
Loading dose: 2mg/kg IV
max 60mg
12
Q
Special considerations
A
Pregnancy Category C
