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Pharmacology > Dopamine > Flashcards

Dopamine Flashcards

1
Q

What is Dopamine’s trade name?

A

Intropin

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2
Q

What class is Dopamine?

A

Sympathomimetic

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3
Q

What receptors does Dopamine act on?

A

Alpha-1 and Beta-1 adrenergic receptors

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4
Q

What other neurotransmitter/hormone is Dopamine related to?

A

Epinephrine and norepinephrine

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5
Q

What is Dopamine’s mechanism of action?

A

binds to alpha-1 or beta-1 receptors to increase BP by increasing the force of contraction (positive inotrope), increase HR (positive chronotrope), or increase peripheral vasoconstriction

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6
Q

What is a low/moderate dose of Dopamine?

A

2-10mcg/kg/min

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7
Q

What does a low/moderate dose of Dopamine do?

A

increase contractility, increase cardiac output, increase BP (Beta adrenergic effect)

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8
Q

What is a high dose of Dopamine?

A

11-20mcg/kg/min

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9
Q

What does a high dose of Dopamine do?

A

peripheral arterial and venous constriction (Alpha adrenergic effects)

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10
Q

Indications to use Dopamine

A 
hemodynamically significant hypotension in the absence of hypovolemia
symptomatic bradycardia (second line drug after atropine)
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11
Q

Contraindications to Dopamine

A

hypersensitivity
tachydysrhythmias
VF
tumor in adrenal gland

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12
Q

Dopamine Dose (adult)

A

Usual infusion rate: 2-20mcg/kg/min

For hypotension after return of spontaneous circulation: 5-10mcg/kg/min

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13
Q

Dopamine Dose (pediatric)

A

2-20mcg/kg/min (if infusion dose >20mcg/kg/min is required, consider an alternative adrenergic agent ex: epinephrine or norepinephrine)

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14
Q

Adverse reactions to Dopamine

A 
dose related tachydysrhythmias
hypertension
increased myocardial oxygen demand (ischemia)
headache
anxiety
nausea and vomiting
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15
Q

Onset of Dopamine

A

2-4 min

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16
Q

Duration of Dopamine

A

10-15 min

17
Q

Route for Dopamine

A

IV/IO

18
Q

Drug interactions for Dopamine

A
  • may be deactivated by alkaline solutions
  • MAO inhibitors may potentiate the effects of Dopamine
  • beta adrenergic antagonists may blunt the inotropic response
19
Q

Special Considerations for Dopamine

A
  • pregnancy safety: category C
  • infuse through a large vein to avoid exacerbation injury
  • use an infusion pump to ensure precise flow rates

Pharmacology (8 decks)

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