Methotrexate Flashcards

1
Q

True or False: Methotrexate is classified as an antimetabolite.

A

True (A folate analog)

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2
Q

What is the mechanism of action of Methotrexate?

A

Methotrexate inhibits dihydrofolate reductase, preventing the synthesis of tetrahydrofolate (THF), leading to decreased DNA synthesis and cell proliferation.

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3
Q

What is the effect of Methotrexate on immune function?

A

It is immunosuppressive.

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4
Q

What is the mechanism by which Methotrexate exerts its anti-inflammatory effects?

A

It inhibits the proliferation of lymphocytes and the production of pro-inflammatory cytokines.

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5
Q

What is the primary route of administration for Methotrexate?

A

Oral and parenteral (intramuscular or intravenous).

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6
Q

What is the typical starting dose of Methotrexate for rheumatoid arthritis?

A

7.5 to 15 mg once weekly.

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7
Q

Methotrexate is contraindicated in patients with __________.

A

severe renal impairment.

vvvvvvvvvvv

MTX causes nephrotoxicity.

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8
Q

What should be avoided while taking Methotrexate?

A

Alcohol consumption.

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9
Q

Fill in the blank: Methotrexate is commonly used to treat __________.

A

rheumatoid arthritis, psoriasis, and certain types of cancer.

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10
Q

What cancers does Methotrexate treat?

A

Leukemias, lymphomas, breast cancer, head and neck cancer, lung cancer.

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11
Q

Which leukemia is Methotrexate primarily used to treat?

A

Acute lymphoblastic leukemia (ALL).

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12
Q

Fill in the blank: Methotrexate is often used in combination with __________ for the treatment of certain cancers.

A

other chemotherapeutic agents.

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13
Q

What are the non-cancer uses of Methotrexate?

A

First-line treatment for rheumatoid arthritis, vasculitis, ectopic pregnancy, and psoriasis.

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14
Q

What is the dosing strategy for Methotrexate in treating rheumatoid arthritis?

A

Typically started at low doses once weekly.

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15
Q

Methotrexate and _________ is the treatment for molar pregnancies.

A

Surgery

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16
Q

What is the main reason for using Methotrexate in ectopic pregnancy?

A

To stop the growth of trophoblastic tissue.

17
Q

True or False: Methotrexate is effective in treating Crohn’s disease.

18
Q

True or False: Methotrexate can cause hepatotoxicity.

19
Q

What is a common hematologic side effect of Methotrexate?

A

Methotrexate causes megaloblastic anemia and overall leads to myelosuppression (bone marrow suppression) leading to pancytopenia due to folate deficiency.

20
Q

What laboratory test should be monitored regularly in patients on Methotrexate?

A

Complete blood count (CBC) and liver function tests due to pancytopenia and hepatotoxicity.

21
Q

Is the myleosuppression caused by methotrexate reversible?

A

Myelosuppression caused by methotrexate is reversible with leucovorin.

22
Q

True or False: Methotrexate can cause pulmonary toxicity.

23
Q

What specific lung complication can Methotrexate cause?

A

Pulmonary fibrosis (restrictive lung disease).

24
Q

Fill in the blank: Methotrexate can lead to __________ if used in high doses.

A

gastrointestinal toxicity.

25
Q

What oral issue does methotrexate cause?

A

Mucositis (eg, mouth ulcers).

26
Q

What should be done if a patient develops severe side effects from Methotrexate?

A

Discontinue the medication and provide supportive care.

27
Q

What is the antidote for Methotrexate toxicity?

A

Leucovorin (folinic acid).

28
Q

Which vitamin can help mitigate the side effects of Methotrexate?

A

Folic acid.

29
Q

True or False: Methotrexate is teratogenic.

A

True. Folate deficiency leads to neural tube defects.

30
Q

Which population should exercise caution when using Methotrexate?

A

Pregnant women and those planning to become pregnant.