5-FU Flashcards
What is the mechanism of action (MOA) of 5-FU?
5-FU works by inhibiting thymidylate synthase, which is essential for DNA synthesis.
True or False: capecitabine is a prodrug for 5-FU.
True.
Which enzyme does 5-FU primarily inhibit?
Thymidylate synthase.
What type of drug is 5-FU classified as?
Antineoplastic agent (A pyrimidine analog).
What is the primary route of metabolism for 5-FU?
Liver.
What is the mechanism by which 5-FU induces cell death?
By disrupting DNA synthesis and function.
Fill in the blank: 5-FU is commonly used to treat __________ cancer.
colorectal.
What are common uses of 5-FU?
Colorectal cancer, breast cancer, stomach cancer, basal cell carcinoma, and head and neck cancers.
Fill in the blank: 5-FU is part of the __________ therapy for some solid tumors.
multimodal.
True or False: 5-FU can be used as a topical treatment for skin cancers.
True.
Which method of administration is often used for 5-FU?
Intravenous (IV) infusion.
What is a major side effect of 5-FU?
Myelosuppression.
What skin-related complication occurs with 5-FU?
Photosensitivity and hyperpigmentation.
Which patient population should avoid 5-FU?
Patients with known hypersensitivity to 5-FU.
True or False: 5-FU is contraindicated in patients with severe bone marrow suppression.
True.
What is the role of leucovorin when used with 5-FU?
Leucovorin enhances the efficacy of 5-FU.
Fill in the blank: 5-FU can cause __________ syndrome, characterized by hand-foot skin reactions.
hand-foot.
vvvvvvvvvvvvv
palmar-plantar erythrodysesthesia (hand-foot syndrome).
What is the typical dosing schedule for 5-FU in cancer treatment?
It varies, but often given in cycles every 28 days.
What laboratory test should be monitored during 5-FU treatment?
Complete blood count (CBC).
True or False: 5-FU is effective as a single agent in advanced colorectal cancer.
False; it is often used in combination with other agents.
What is one of the unique toxicities associated with 5-FU?
Mucositis.
Which specific cancer is 5-FU NOT typically used to treat?
Prostate cancer.
Fill in the blank: 5-FU is often combined with __________ in the treatment of colorectal cancer.
oxaliplatin.
True or False: 5-FU can be administered orally.
True; it has an oral formulation.
What is the potential risk of using 5-FU in patients with dihydropyrimidine dehydrogenase deficiency?
Increased risk of toxicity.
What is a common side effect of 5-FU related to the gastrointestinal system?
Diarrhea.
