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Block 8 Week 5 Colt > Meth - Ley > Flashcards

Meth - Ley Flashcards

1
Q

Meth causes the release of DA, S, and NE where?

A

CNS and PNS

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2
Q

t/f: meth crosses the bbb

A

true

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3
Q

meth use is comorbid for which psych conditions?

A 
anxiety
depression
ADHD
mania
conduct d/o
obesity
ASPD
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4
Q

when do most meth users see dependence?

A

young; around 13-17; used multiple substances and used daily

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5
Q

What is the attraction of meth?

A

desire to cope with emotional stress
stay awake
enhance sex
reduce weight

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6
Q

how can you take meth?

A 
smoke it
snort it
eat it
drink it
shoot it
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7
Q

about what percent of teens say it would be easy for them to get ahold of meth?

A

1 in 4

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8
Q

why are most children in HI in foster care?

A

meth moms

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9
Q

compared to cocaine users, how do meth users look?

A
  1. more likely to be single, white, unemployed
  2. use daily and at younger age
  3. experience depression and thoughts of self harm
  4. more family issues, more weed
  5. more HIV pos
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10
Q

meth stimulates release and (pre/post) synaptic uptake of S, D, and NE

A

presynaptic

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11
Q

it takes (single/multiple) doses of meth to impair cognitive fxn

A

one fucking dose

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12
Q

how is meth metabolized?

A

hepatic hydroxylation and dealkylation

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13
Q

inhibitors of which CYP decreases meth elimination?

A

2D6

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14
Q

when does meth plasma concn peak?

A

2.6-3.6 hours

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15
Q

what is the half life of meth?

A

10 hours

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16
Q

how many percent above baseline does meth increase dopamine?

A

1200%

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17
Q

how long does the cocaine high last?

A

15-30 minutes

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18
Q

how long does the meth high last?

A

8-24 hours

19
Q

t/f: street meth is highly PURE

A

true; 90-100% pure in crystal

20
Q

tolerance to meth is….

A

IMMEDIATE

21
Q

what are the acute effects of meth?

A

Heightened awareness, grandiosity, feeling of being alive, sexual arousal, increased self confidence.
Single doses improve cognition.
Nervousness, insomnia, jerky movements, anxiety, sweating, palpitations, incessant talking, confusion, irritability, bruxism, hyperthermia, dizziness, pupillary dilation, impaired speech, tremors, vision loss.

22
Q

what are the common causes of death from meth?

A

homicide
suicide
MVAs
sales/distribution

23
Q

What are the biological causes of death from meth?

A 
stroke
CV collapse
pulmonary edema
MI 
renal failure
24
Q

what are the long term psychological effects of meth?

A 
chronic anxiety
depression
anger
panic
paranoia
tinnitus
25
Q

what are the greatest areas of volume loss from chronic meth use?

A 
limbic system (emotion and reward)
hippocampus (memory)
26
Q

what are the cognitive changes in the first few weeks of meth use?

A

deficits in decision making, accuracy, and speed

27
Q

Frontal lobe damage in meth is related to…

A

the amount of use; may contribute to craving

28
Q

What explains affective dysregulation in meth use?

A

metabolic abnl’s in the limbic system

29
Q

meth use results in reduced (DA/S) transporter density

A

S

30
Q

t/f: meth is neurotoxic

A

true

31
Q

What are the effects on the newborn born to a crack mom

/

A 
low birth weight
smaller subcortical brain volume
poor visual recognition
increased aggression
impaired social adjustment
difficulties with math and language
32
Q

what causes meth mouth?

A 
vasoconstriction
decreased salivary flow
vomiting
bruxism
high sugar
abandon oral hygeine
33
Q

what are the withdrawal sx from meth?

A

Symptom clusters
Hyperarousal (agitation, craving, dreams)
Vegetative symptoms (sadness, anhedonia, increased appetite)
Anxiety
Dysphoria, affective instability, sleep disturbance
Apathy syndrome

34
Q

most of our meth treatment comes from the model from what other drug?

A

coke

35
Q

What are the major tx models for meth?

A

CBT
contingency model
matrix model

36
Q

What are the challenges in treating meth addiction?

A

poor treatment engagement and drop out, high relapse rate, dysphoria and cognitive impairment

37
Q

the matrix models uses what three approaches?

A

cognitive
behavioral
psychological

38
Q

What are the goals of the matrix model?

A

educate about addiction
involve family
12 step
testing

39
Q

what can you give a recovering meth addict to deal with dysphoria, craving, and cognitive impairment/

A

SSRI

40
Q

what does buproprion do for a meth head?

A

reduces the desire to use

41
Q

what types of agonist replacements can you give a meth head?

A

modafinil, ritalin

42
Q

What do you give a meth user for pain?

A

baclofen

43
Q

What do you give a meth head to lower hyperarousal, anxiety, and withdrawal symptoms?

A

mirtazapine

Block 8 Week 5 Colt (12 decks)

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