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Block 8 Week 5 Colt > Cannabis - Ley > Flashcards

Cannabis - Ley Flashcards

1
Q

what is the most widely used strain of cannabis?

A

cannabis sativa

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2
Q

What are the two main derivatives of cannabis?

A

maryjane

hashish

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3
Q

Which strain of cannabis has higher CBD to THC ratio?

A

indica

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4
Q

Which cannabis is good for appetite induction?

A

indica

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5
Q

Which strain of cannabis is more uplifting?

A

sativa

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6
Q

what are the abuse criteria for marijuana?

A 
One or more, over 1 year
Repeated inability to meet obligations
Repeated when dangerous (driving)
Repeated legal problems
Continued despite interpersonal/social problems
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7
Q

t/f: the majority of illicit drug users in the US smoke cannabis exclusively

A

true

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8
Q

How many americans meet the criteria for weed dependence?

A

4 million

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9
Q 
Order the drugs in order of dependence:
tobacco
weed
heroin
cocaine
A

tobacco
heroin
cocaine
weed

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10
Q

what are the non-THC active compounds in weed?

A

CBD cannabidiol
CBN cannabinol
THCV

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11
Q

What are the three classes of cannabinoids?

A

phytocannabinoids
endocannabinoids
synthetic cannabinoids

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12
Q

endocannabinoids are the intracellular (blank) messengers

A

lipid

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13
Q

What was the first ID’d endocannabinoid?

A

anandamide

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14
Q

CB1 is found mostly in which brain structures?

A

basal ganglia

limbic system

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15
Q

CB2 receptors are found in what system and organ?

A

immune system; spleen

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16
Q

How are endocannabinoids metabolized?

A

CYP 2C9

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17
Q

what are the synthetic endocannabinoids?

A

dronabinol
nabilone
rimonabat

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18
Q

THC increases dopamine release in what brain structure?

A

NA

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19
Q

What are the effects of marijuana on the frontal cortex?

A

decision making
social skills
high level consciousness
euphoria and dreamy feeling

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20
Q

What are the effects of MJ on the hippocampus?

A

info storage and retrieval

short term effects on memory

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21
Q

What are the effects of MJ on thecerebellum?

A

effects on coordination

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22
Q

What are the effects of MJ on the nucleus accumbens?

A

part of the reward pathway

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23
Q

What are the effects of MJ on the brainstem?

A

lack of effect here explains why you can’t OD on it

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24
Q

what part of the weed has the most thc?

A

the flower tops

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25
Q

what is the bioavailability of MJ?

A

25%

26
Q

how quickly does thc onset?

A

within seconds, full effect in minutes

27
Q

Oral ingestion of thc does what to its onset?

A

delays it

28
Q

What is the plasma elimination half life of thc?

A

56 hours

29
Q

what happens to the plasma elimination half life in people who smoke weed chronically?

A

elimination half life halved

30
Q

Where is thc sequestered in the body?

A

in the fat; tissue half life about a week; may take as long as 30 days

31
Q

weed has what property that makes it useful in the treatment of ischemia?

A

antioxidant

32
Q

what are the beneficial effects of MJ?

A

pain relief
appetite stimulation
chemo related N/V

33
Q

t/f: regular exposure to MJ affects lungs equally as tobacco

A

false; does not affect lung function or total function capacity

34
Q

MJ increases the risk of psychosis over ten years by what fold?

A

2x

35
Q

what three brain structures release DA in response to MJ?

A

subcortical ventral tegmentum
NA
striatum
medial PFC

36
Q

After an initial period of excitement, MJ causes CNS…

A

depression

37
Q

what are the effects of MJ on motor function?

A

delayed response time
dysarthria
pursuit movement
physical strength

38
Q

What are the other effects of weed on the body?

A 
Cognition- user may experience FOI that is felt to be profound, accelerated speed of thoughts.
Short-term memory deficits
Amotivational syndrome
Substance-induced psychosis
Cardiac output increased, up to 30%
39
Q

MJ can decrease the volume of which brain structure?

A

amygdala

40
Q

Is there any correlation between MJ use and hippocampal volume?

A

nope; not assc’d with age of onset or total lifetime use

41
Q

T/F: long term test performance is not affected by weed use

A

true

42
Q

Youths who use MJ are (blank) times as likely to experiment with other drugs

A

9x with drugs or alcohol
5x more likely to steal
4x more likely to be violent

43
Q

What are the associations between early adolescence and MJ use?

A 
more likely to engage in risky behaviors:
delinquency
multiple sexual partners
view drugs as not harmful
having more delinquent friends
44
Q

what are the risk factors for MJ abuse?

A 
conduct problems
family conflict
association with deviant peers
early subjective response (5 + rxns had 20x greater risk)
genetic factors
45
Q

Genetic differences in the (blank) dopamine system are risk factors for MJ abuse

A

mesolimbic DA system

46
Q

frequent MJ use during early adulthood increases the risk of (blank) abuse, adverse school experiences, psych co-issues, and criminal issues

A

polysubstance abuse

47
Q

T/F: there is an established link between marijuana use and progression to other drugs

A

false!!!

48
Q

t/f: there is a dose dependent risk of psychosis with MJ use

A

true

49
Q

Psychosocial impairment is seen greatest in which age group?

A

adolescents

50
Q

A third of people who smoke pot will experience their first (blank) within 48 hours

A

panic attack

51
Q

What are the cannabis withdrawal sx?

A

Variegated symptoms- anxiety, anorexia, bp/hr changes, sweating, diarrhea.
Most frequent- emotional. Withdrawal doesn’t usually cause physical, psychiatric, or medical issues.

52
Q

most people dont quit smoking pot until what age?

A

older than 30

53
Q

is bupropion effective in treating MJ withdrawal?

A

no

54
Q

(blank) showed a reduction in MJ use and sig. decreases in anxiety

A

buspirone

55
Q

is divalproex effective in treating MJ withdrawal?

A

nope

56
Q

Describe the level of evidence for using mirtazapine for MJ withdrawal

A

anecdotal

57
Q

what are the effective psychosocial interventions for MJ tx?

A

Drug counseling, motivational interviewing, CBT, CM, relapse prevention, social support

58
Q

T/F: there is no difference in CBT vs support groups in reducing MJ use

A

true

59
Q

T/F: there are positive effects in terms of treatment retention after encounters with the justice system

A

tru

60
Q

What do you need to do to effectively tx adolescents?

A

involve fam

Block 8 Week 5 Colt (12 decks)

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