Metabolism XIII Flashcards
What is the function of pancreatic lipase in lipid transport?
Degredation of dietary TGs in the small intestine (p.115)
What is the function of lipoprotein lipase (LPL) in lipid transport?
Degredation of TGs circulating in chylomicrons and VLDLs (p.115)
What is the function of Hepatic TG lipase (HL) in lipid transport?
Degradation of TGs remaining in IDL (p.115)
What is the function of hormone sensitive lipase in lipid transport?
Degredation of TGs stored in adipocytes (p.115)
Which two enzymes are responsible for transfer of cholesterol esters to VLDL, IDL, and LDL?
LCAT (lecithin-cholesterol acyltransferase) and CETP (cholesterol ester transfer protein) (P.115)
What is the function of LCAT (lecithin-cholesterol acyltransferase)?
Catalyses esterification of cholesterol (p.115)
What is the function of CETP (cholesterol ester transfer protein)?
Mediates the transfer of cholesterol esters to other lipoprotein particles (p.115)
What are the 5 major apolipoproteins?
E, A-I, C-II, B-48, B-100 (p.115)
What is the function of apolioprotein E?
To mediate remnant uptake (p.115)
What is the function of apolioprotein A-I?
To activate LCAT (p.115)
What is the function of apolioprotein C-II?
Cofactor for lipoprotein lipase (p.115)
What is the function of apolioprotein B-48?
To mediate chylomicron secretion (p.115)
What is the function of apolioprotein B-100?
To bind to LDL receptors (p.115)
Where are apolioproteins E found?
Chylomicrons, chylomicron remnants, VLDL, IDL, HDL (p.115)
Where are apolioproteins A-I found?
HDL (p.115)
Where are apolioproteins C-II found?
Chylomicrons, VLDL, HDL (p.115)
Where are apolioproteins B-48 found?
Chylomicrons, chylomicron remnants (p.115)
Where are apolioproteins B-100 found?
VLDL, IDL, LDL (p.115)
What are apolipoproteins?
Proteins that bind lipids to form lipoproteins that can be transported through the lymphatic and circulatory systems (p.115)
What are lipoproteins composed of?
Varying proportions of cholesterol, triglycerides (TGs), and phospholipids (p.116)
Which two lipoproteins carry the most cholesterol?
LDL and HDL (p.116)
To where does LDL transport cholesterol?
From the liver to the tissues (p.116)
To where does HDL transport cholesterol?
From the periphery to the liver (p.116)
What is the function of chylomicrons?
To deliver dietary TGs to peripheral tissue. They deliver cholesterol to the liver in the form of chylomicron remnants which are mostly depleted of their triacylglycerols (p.116)
What secretes chylomicrons?
Intestinal epithelial cells (p.116)
What is the function of VLDL?
To deliver hepatic TGs to peripheral tissue (p.116)
