Metabolism XIII

Question 1

What is the function of pancreatic lipase in lipid transport?

Answer 1

Degredation of dietary TGs in the small intestine (p.115)

Question 2

What is the function of lipoprotein lipase (LPL) in lipid transport?

Answer 2

Degredation of TGs circulating in chylomicrons and VLDLs (p.115)

Question 3

What is the function of Hepatic TG lipase (HL) in lipid transport?

Answer 3

Degradation of TGs remaining in IDL (p.115)

Question 4

What is the function of hormone sensitive lipase in lipid transport?

Answer 4

Degredation of TGs stored in adipocytes (p.115)

Question 5

Which two enzymes are responsible for transfer of cholesterol esters to VLDL, IDL, and LDL?

Answer 5

LCAT (lecithin-cholesterol acyltransferase) and CETP (cholesterol ester transfer protein) (P.115)

Question 6

What is the function of LCAT (lecithin-cholesterol acyltransferase)?

Answer 6

Catalyses esterification of cholesterol (p.115)

Question 7

What is the function of CETP (cholesterol ester transfer protein)?

Answer 7

Mediates the transfer of cholesterol esters to other lipoprotein particles (p.115)

Question 8

What are the 5 major apolipoproteins?

Answer 8

E, A-I, C-II, B-48, B-100 (p.115)

Question 9

What is the function of apolioprotein E?

Answer 9

To mediate remnant uptake (p.115)

Question 10

What is the function of apolioprotein A-I?

Answer 10

To activate LCAT (p.115)

Question 11

What is the function of apolioprotein C-II?

Answer 11

Cofactor for lipoprotein lipase (p.115)

Question 12

What is the function of apolioprotein B-48?

Answer 12

To mediate chylomicron secretion (p.115)

Question 13

What is the function of apolioprotein B-100?

Answer 13

To bind to LDL receptors (p.115)

Question 14

Where are apolioproteins E found?

Answer 14

Chylomicrons, chylomicron remnants, VLDL, IDL, HDL (p.115)

Question 15

Where are apolioproteins A-I found?

Answer 15

HDL (p.115)

Question 16

Where are apolioproteins C-II found?

Answer 16

Chylomicrons, VLDL, HDL (p.115)

Question 17

Where are apolioproteins B-48 found?

Answer 17

Chylomicrons, chylomicron remnants (p.115)

Question 18

Where are apolioproteins B-100 found?

Answer 18

VLDL, IDL, LDL (p.115)

Question 19

What are apolipoproteins?

Answer 19

Proteins that bind lipids to form lipoproteins that can be transported through the lymphatic and circulatory systems (p.115)

Question 20

What are lipoproteins composed of?

Answer 20

Varying proportions of cholesterol, triglycerides (TGs), and phospholipids (p.116)

Question 21

Which two lipoproteins carry the most cholesterol?

Answer 21

LDL and HDL (p.116)

Question 22

To where does LDL transport cholesterol?

Answer 22

From the liver to the tissues (p.116)

Question 23

To where does HDL transport cholesterol?

Answer 23

From the periphery to the liver (p.116)

Question 24

What is the function of chylomicrons?

Answer 24

To deliver dietary TGs to peripheral tissue. They deliver cholesterol to the liver in the form of chylomicron remnants which are mostly depleted of their triacylglycerols (p.116)

Question 25

What secretes chylomicrons?

Answer 25

Intestinal epithelial cells (p.116)

Question 26

What is the function of VLDL?

Answer 26

To deliver hepatic TGs to peripheral tissue (p.116)