Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

P2 IDT > Metabolism/Induction/Inhibition > Flashcards

Metabolism/Induction/Inhibition Flashcards

1
Q

What metabolizes phenobarbital

A

2C9 and 2C19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does phenobarbital induce

A

P450s and UGTs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does phenobarbial inhibit

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What metabolizes phenytoin

A

2C9 and 2C19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does phenytoin induce

A

P450s and UGTs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What does phenytoin inhibit

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What metabolizes ethosuximide

A

3A4 and 2E1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What does ethosuximide induce

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What does ethosuximide inhibit

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What metabolizes valproic acid

A

glucuronidation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What does valproic acid induce

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What does valproic acid inhibit

A

2C9 and UGTs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What metabolizes carbamazepine

A

3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What does carbamazepine induce

A

P450s and UGTs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What does carbamazepine inhibit

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What does oxcarbazepine induce

A

3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What does oxcarbazepine inhibit

A

2C19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What does eslicarbazepine induce

A

3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What does eslicarbazepine inhibit

A

2C19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What metabolizes gabapentin

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What does gabapentin induce

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What does gabapentin inhibit

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What does vigabatrin induce

A

2C9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What metabolizes lamotrigine

A

major: glucuronidation minor: P450s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What does topiramate induce

A

3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What does topiramate inhibit

A

2C19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What metabolizes zonisamide

A

3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What metabolizes tiagabine

A

3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What metabolizes lacosamide

A

2C19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

What does levetiracetam induce

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What does levetiracetam inhibit

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What metabolizes brivaracetam

A

2C19

33
Q

What does rufinamide induce

A

3A4

34
Q

What does rufinamide inhibit

A

2E1

35
Q

What metabolizes perampanel

A

3A4

36
Q

Strong inducers of various P450s and some UGTs

A

phenobarbital/primidone, phenytoin/fosphenytoin, carbamazepine

37
Q

Moderate inducers of 3A4

A

Oxcarbazepine and eslicarbazepine acetate

38
Q

Moderate inducers of 2C9

A

Vigabatrin

39
Q

Weak inducers of 3A4

A

Topiramate and rufinamide

40
Q

Inhibitors of 2C19

A

Oxcarbazepine, eslicarbazepine acetate, fluvoxamine and topiramate (weak)

41
Q

Inhibitors of 2C9

A

Valproate

42
Q

Inhibitors of 2E1

A

Rufinamide (weak)

43
Q

Inhibitors of epoxide hydrolase

A

Valproate

44
Q

Inhibitors of UGT

A

Valproate

45
Q

3A4 metabolizes

A

ethosuximide, carbamazepine, zonisamide, tiagabine, perampanel, trazodone, nefazodone, vilazodone, venlafaxine, desvenlafaxine, levomilnacipran

46
Q

3A4 is induced by

A

phenobarbital, primidone, phenytoin, carbamazepine, oxcarbazepine, eslicarbazepine, topiramate, rufinamide

47
Q

3A4 is inhibited by

A

nefazodone

48
Q

UGT is induced by

A

phenobarbital, primidone, phenytoin, carbamazepine

49
Q

2C9 metabolizes

A

phenobarbital, phenytoin

50
Q

2C19 metabolizes

A

phenobarbital, phenytoin, lacosamide, brivaracetam

51
Q

Epoxide hydroxylase metabolizes

A

carbamazepine 10,11 epoxide

52
Q

2D6 metabolizes

A

amitriptyline, imipramine, clomiprimine, doxepin, paroxetine, fluoxetine, fluvoxamine, sertraline, citalopram, vortioxetine, venlafaxine, duloxetine

53
Q

2D6 is inhibited by

A

fluoxetine, sertraline, duloxetine, paroxetine, bupropion

54
Q

GABA-T is inhibited by

A

Valproate, vigabatrin

55
Q

SSA dehydrogenase is inhibited by

A

valproate

56
Q

Glutamic acid decarboxylase is induced by

A

valproate

57
Q

What is the major route of metabolism for TCAs

A

2D6

58
Q

What is the minor route of metabolism for TCAs

A

2C19

59
Q

What is the primary CYP for SSRI metabolism

A

2D6

60
Q

What does fluoxetine (and norfluoxetine) inhibit

A

2D6

61
Q

What does sertraline inhibit

A

2D6

62
Q

What does paroxetine inhibit

A

2D6 (irreversibly)

63
Q

What does fluvoxamine inhibit

A

1A2 and 2C19

64
Q

What SSRI is best for someone on a lot of medications that undergo P450 metabolism?

A

Citalopram or escitalopram

65
Q

What metabolizes vilazodone

A

3A4

66
Q

What metabolizes vortioxetine

A

2D6

67
Q

What metabolizes trazodone

A

3A4

68
Q

What metabolizes nefazodone

A

3A4

69
Q

What does nefazodone inhibit

A

3A4

70
Q

What metabolizes venlafaxine

A

3A4 and 2D6

71
Q

What metabolizes desvenlafaxine

A

glucuronidation (major) 3A4 (minor)

72
Q

What metabolizes duloxetine

A

1K2 and 2D6

73
Q

What does duloxetine inhibit

A

2D6

74
Q

What metabolizes levomilnacipran

A

3A4

75
Q

What metabolizes bupropion

A

2B6

76
Q

What does bupropion inhibit

A

2D6

77
Q

What does bupropion induce

A

none

78
Q

What does St. John’s Wort induce

A

3A

P2 IDT (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions