Metabolism/Induction/Inhibition

Question 1

What metabolizes phenobarbital

Answer 1

2C9 and 2C19

Question 2

What does phenobarbital induce

Answer 2

P450s and UGTs

Question 3

What does phenobarbial inhibit

Answer 3

none

Question 4

What metabolizes phenytoin

Answer 4

2C9 and 2C19

Question 5

What does phenytoin induce

Answer 5

P450s and UGTs

Question 6

What does phenytoin inhibit

Answer 6

none

Question 7

What metabolizes ethosuximide

Answer 7

3A4 and 2E1

Question 8

What does ethosuximide induce

Answer 8

none

Question 9

What does ethosuximide inhibit

Answer 9

none

Question 10

What metabolizes valproic acid

Answer 10

glucuronidation

Question 11

What does valproic acid induce

Answer 11

none

Question 12

What does valproic acid inhibit

Answer 12

2C9 and UGTs

Question 13

What metabolizes carbamazepine

Answer 13

3A4

Question 14

What does carbamazepine induce

Answer 14

P450s and UGTs

Question 15

What does carbamazepine inhibit

Answer 15

none

Question 16

What does oxcarbazepine induce

Answer 16

3A4

Question 17

What does oxcarbazepine inhibit

Answer 17

2C19

Question 18

What does eslicarbazepine induce

Answer 18

3A4

Question 19

What does eslicarbazepine inhibit

Answer 19

2C19

Question 20

What metabolizes gabapentin

Answer 20

none

Question 21

What does gabapentin induce

Answer 21

none

Question 22

What does gabapentin inhibit

Answer 22

none

Question 23

What does vigabatrin induce

Answer 23

2C9

Question 24

What metabolizes lamotrigine

Answer 24

major: glucuronidation minor: P450s

Question 25

What does topiramate induce

Answer 25

3A4

Question 26

What does topiramate inhibit

Answer 26

2C19

Question 27

What metabolizes zonisamide

Answer 27

3A4

Question 28

What metabolizes tiagabine

Answer 28

3A4

Question 29

What metabolizes lacosamide

Answer 29

2C19

Question 30

What does levetiracetam induce

Answer 30

none

Question 31

What does levetiracetam inhibit

Answer 31

none

Question 32

What metabolizes brivaracetam

Answer 32

2C19

Question 33

What does rufinamide induce

Answer 33

3A4

Question 34

What does rufinamide inhibit

Answer 34

2E1

Question 35

What metabolizes perampanel

Answer 35

3A4

Question 36

Strong inducers of various P450s and some UGTs

Answer 36

phenobarbital/primidone, phenytoin/fosphenytoin, carbamazepine

Question 37

Moderate inducers of 3A4

Answer 37

Oxcarbazepine and eslicarbazepine acetate

Question 38

Moderate inducers of 2C9

Answer 38

Vigabatrin

Question 39

Weak inducers of 3A4

Answer 39

Topiramate and rufinamide

Question 40

Inhibitors of 2C19

Answer 40

Oxcarbazepine, eslicarbazepine acetate, fluvoxamine and topiramate (weak)

Question 41

Inhibitors of 2C9

Answer 41

Valproate

Question 42

Inhibitors of 2E1

Answer 42

Rufinamide (weak)

Question 43

Inhibitors of epoxide hydrolase

Answer 43

Valproate

Question 44

Inhibitors of UGT

Answer 44

Valproate

Question 45

3A4 metabolizes

Answer 45

ethosuximide, carbamazepine, zonisamide, tiagabine, perampanel, trazodone, nefazodone, vilazodone, venlafaxine, desvenlafaxine, levomilnacipran

Question 46

3A4 is induced by

Answer 46

phenobarbital, primidone, phenytoin, carbamazepine, oxcarbazepine, eslicarbazepine, topiramate, rufinamide

Question 47

3A4 is inhibited by

Answer 47

nefazodone

Question 48

UGT is induced by

Answer 48

phenobarbital, primidone, phenytoin, carbamazepine

Question 49

2C9 metabolizes

Answer 49

phenobarbital, phenytoin

Question 50

2C19 metabolizes

Answer 50

phenobarbital, phenytoin, lacosamide, brivaracetam

Question 51

Epoxide hydroxylase metabolizes

Answer 51

carbamazepine 10,11 epoxide

Question 52

2D6 metabolizes

Answer 52

amitriptyline, imipramine, clomiprimine, doxepin, paroxetine, fluoxetine, fluvoxamine, sertraline, citalopram, vortioxetine, venlafaxine, duloxetine

Question 53

2D6 is inhibited by

Answer 53

fluoxetine, sertraline, duloxetine, paroxetine, bupropion

Question 54

GABA-T is inhibited by

Answer 54

Valproate, vigabatrin

Question 55

SSA dehydrogenase is inhibited by

Answer 55

valproate

Question 56

Glutamic acid decarboxylase is induced by

Answer 56

valproate

Question 57

What is the major route of metabolism for TCAs

Answer 57

2D6

Question 58

What is the minor route of metabolism for TCAs

Answer 58

2C19

Question 59

What is the primary CYP for SSRI metabolism

Answer 59

2D6

Question 60

What does fluoxetine (and norfluoxetine) inhibit

Answer 60

2D6

Question 61

What does sertraline inhibit

Answer 61

2D6

Question 62

What does paroxetine inhibit

Answer 62

2D6 (irreversibly)

Question 63

What does fluvoxamine inhibit

Answer 63

1A2 and 2C19

Question 64

What SSRI is best for someone on a lot of medications that undergo P450 metabolism?

Answer 64

Citalopram or escitalopram

Question 65

What metabolizes vilazodone

Answer 65

3A4

Question 66

What metabolizes vortioxetine

Answer 66

2D6

Question 67

What metabolizes trazodone

Answer 67

3A4

Question 68

What metabolizes nefazodone

Answer 68

3A4

Question 69

What does nefazodone inhibit

Answer 69

3A4

Question 70

What metabolizes venlafaxine

Answer 70

3A4 and 2D6

Question 71

What metabolizes desvenlafaxine

Answer 71

glucuronidation (major) 3A4 (minor)

Question 72

What metabolizes duloxetine

Answer 72

1K2 and 2D6

Question 73

What does duloxetine inhibit

Answer 73

2D6

Question 74

What metabolizes levomilnacipran

Answer 74

3A4

Question 75

What metabolizes bupropion

Answer 75

2B6

Question 76

What does bupropion inhibit

Answer 76

2D6

Question 77

What does bupropion induce

Answer 77

none

Question 78

What does St. John's Wort induce

Answer 78

3A