Metabolism

Question 1

WHERE does glycolysis occur?

Answer 1

In the cytoplasm

in all cells

Question 2

SUBSTRATE of glycolysis

Answer 2

Glucose

Question 3

END PRODUCT of glycolysis

Answer 3

Pyruvate or lactate

Question 4

RATE-LIMITING step in glycolysis

Answer 4

F6P to F1,6BP by PFK-1

Question 5

3 irreversible steps in glycolysis

Answer 5

Step 1: phosphorylation of glucose
Step 3: phosphorylation of F6P
Step 10: Formation of pyruvate

Question 6

WHAT is gluconeogenesis for?

Answer 6

Production of glucose from intermediates of glycolysis and TCA, fats, lactate and glucogenic AA

Question 7

WHERE dies GLUCONEOGENESIS occur?

Answer 7

Liver (90%)
Kidney (10% to 40% during prolonged fasting)
both in the mitochondria and cytoplasm

Question 8

SUBSTRATE of gluconeogenesis

Answer 8

Pyruvate

Question 9

PRODUCT of gluconeogenesis

Answer 9

Glucose

Question 10

RATE-LIMITING step in Gluconeogenesis

Answer 10

F1,6BP to F6P by F1,6 bisphosphatase

Question 11

Impt steps in gluconeogenesis

Answer 11

Step 10: pyruvate to OAA and PEP by pyruvate carboxylase and PEP carboxylase
Step 3: F1,6BP to F6P by Fructose 1,6 bisphosphatase
Step 1: G6P to glucose by glucose 6-phosphatase

Question 12

WHAT is glycolysis for?

Answer 12

Major pathway for glucose metab that converts glucose into 3 carbon compounds to provide energy