Metabolism Flashcards
Exergonic
Endergonic
Reactions where more energy is released than used
Reactions where more energy is used than released
Anabolic
Catabolic
- reductive pathway and uses intermediate metabolites and energy (ATP) to drive synthesis of important cell components
- oxidative pathway releasing lots of free energy and produces intermediate metabolites
What is daily expenditure and what are the components
12000kJ and 9500kJ
BMR
Voluntary physical activity
Process food - diet induced thermogen
Fats are important in the diet
Yield 2.2 times more energy than carbs
Needed for absorption of lipid-soluble vitamins (ADEK)
Some polyunsaturated fatty acids (essential fatty acids) are regulators
Amino acids
Busing blocks of protein
Used in synthesis of essential N compounds - creatine, purines, pyrimidines, heam
BMI
Weight/height2
18-25 Normal
25-30 overweight
30-35 obese
>35 morbidly obese
Malnutrition
- malabsorption
- types of protein malnutrition
An in balance of consumption and expenditure
Malabsorption - coeliac and crohns
Protein deficient - marasmus and kwashiorkor
Marasmus
Kwashiorkor
Commonly under 5. Looks emaciated with obvious signs of loss in muscle and body fat, with no oedema. Hair is thin and dry. Diarrhoea and anaemia present
Normally young child with carb and very low protein diet. Child is apathetic, lethargic, anorexic. Generalised oedema and distended abdomen due to hepatomegaly. Low serum albumin and anaemia
Define homeostasis
The controlling of a dynamic equilibrium own internal environments.
Name cell nutrients
Glucose Amino acids Trigs Cholesterol Fatty acids Lactic acid Total CO2 Urea
Why do cells metabolise nutrients
Energy for cell function - ATP
Building blocks molecules, synthesis for growth, repair and division
Organic precursor molecules that are used to allow interconversion of building block molecules (acetyl~CoA)
Biosynthetic reducing power used in synthesis of cell components (NADPH)
Where do cell nutrients in the blood come from?
Diet
Synthesis in body tissues from precursors
Released from storage in body tissues
What are th evasions chemical transformations that occur to circulating cell nutrients
Degradation - release energy in all cells
Synthesis of components - all tissues except mature erythrocytes
Storage - liver, adipose and skeletal muscle
Interconversion - liver, adipose, kidney cortex
Excretion - liver, kidney and lungs
Oxidation and reduction
Oxidation - addition of O2 and removal of H atom or electron
Reduction - removal of O2 and addition of H atom or electron