Metabolism Flashcards

1
Q

_____ is the building of complex structures from simpler ones, and requires energy, much
of which is supplied by _____.

A

Anabolism; ATP

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2
Q

_____ is the breakdown of complex structures into simpler ones. Much of the energy
released is captured in _____.

A

Catabolism; ATP

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3
Q

_____ is the entire set of reactions comprising both anabolism and catabolism.

A

Metabolism

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4
Q

Carbohydrate is stored in the body as _____.

A

glycogen

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5
Q

_____ is the set of reactions in which the body generates glycogen polymers from
glucose

A

Glycogenesis

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6
Q

When glucose is needed by the body as fuel, glycogen is hydrolyzed back to glucose in a
process called _____.

A

glycogenolysis

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7
Q

In the _____ or _____, both glycogenolysis and gluconeogenesis result in export of
glucose into the blood; in _____, however, the glucose that is produced cannot leave the
cell.

A

liver; kidneys; muscle

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8
Q

Glycolysis occurs in the cell’s _____, and captures some of the energy stored in glucose
or fructose as ATP. It is particularly useful because it does not require oxygen and is
_____.

A

cytoplasm; very fast

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9
Q

Draw a simple diagram of glycolysis showing NAD+, NADH, glucose, ADP, Pi, ATP, and
pyruvate, assuming that oxygen is available.

A

Check question 9. couldn’t paste diagram

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10
Q

Draw a simple diagram of glycolysis showing NAD+, NADH, glucose, ADP, Pi, ATP, and
pyruvate, assuming that oxygen is NOT available.

A

Check question 10 couldn’t paste diagram

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11
Q

If _____, NADH generated during glycolysis is re-oxidized during “oxidative
phosphorylation” and the energy stored in it is _____.

A

oxygen is available; used to

make ATP

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12
Q

If _____, NADH generated during glycolysis is re-oxidized by reducing the product of
glycolysis (pyruvate) to lactate and the energy in the NADH is _____.

A

oxygen is NOT available; lost

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13
Q

Before it can enter the citric acid cycle, pyruvate must be converted to _____. Pyruvate
has three carbons: _____ has two. The “missing” carbon leaves as _____, and the energy
that is released is captured in _____.

A

acetyl-CoA; acetyl-CoA; CO2
;
NADH

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14
Q

When a phosphate is transferred from a molecule to an ADP, the molecule, phosphate
and ADP are _____ in a reaction. The process is called _____.

A

substrates; substrate level

phosphorylation

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15
Q

When a phosphate is added to ADP by the action of ATP synthase, which is driven by a
hydrogen ion gradient generated by the _____ of fuels, the process is called _____.

A

oxidation; oxidative

phosphorylation

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16
Q

The citric acid cycle occurs in the _____, and its purpose is to finish oxidizing fuels that
were partially oxidized elsewhere in the cell in order to _____.

A

mitochondrial matrix; extract as

much energy as possible

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17
Q

The citric acid cycle is often called the _____ cycle.

A

Kreb’s

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18
Q

_____ enters the Kreb’s cycle, and _____ is produced. The energy is captured in _____,
a similar molecule called _____, and _____.

A

Acetyl-CoA; CO2; NADH;

FADH2; ATP

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19
Q

The electron transport chain is found in the _____.

A

inner mitochondrial membrane

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20
Q

Electrons are fed into the electron transport chain by _____ and _____. Their energy is
transferred to a hydrogen ion gradient, and eventually they, and nearby hydrogen ions,
combine with _____ to form _____.

A

NADH; FADH2; oxygen; water

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21
Q

The _____ across the mitochondrial inner membrane is used to power ATP synthase: as
_____ flow through the ATP synthase, ATP is made from ADP and Pi.

A

hydrogen ion gradient; hydrogen

ions

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22
Q

In the absence of oxygen, _____ ATP molecules can be produced from the oxidation of
glucose or other sugars. Most of glucose’s energy is lost to the cell when _____.

A

only two; lactate is discarded

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23
Q

Lactic acid produced by anaerobic glycolysis is transported in the blood to other organs
which can convert it back to _____ so that it can be used in oxidative phosphorylation.

A

pyruvate

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24
Q

In the presence of oxygen, up to _____ ATP can be produced, since the glucose can be
completely, instead of partially, oxidized. There is no need to discard lactate.

A

38

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25
Fats are stored in the body as _____.
triglycerides
26
The first step in fat catabolism is lipolysis, the separation of the _____ and _____ within the triglycerides.
fatty acids; glycerol
27
_____ is a three carbon molecule which can be converted to a glycolytic intermediate; after release by lipolysis it can be used in _____ to form pyruvate or, in the liver, to build _____.
Glycerol; glycolysis; glucose
28
Within a cell's _____, fatty acids undergo beta-oxidation, a process in which _____.
mitochondria; carbons are removed two at a time to form acetyl-CoA
29
In most tissues, acetyl-CoA formed by oxidation of fatty acids is used in _____.
the citric acid cycle
30
. In the liver, pyruvate can be produced from _____ or from _____ as well as from glucose.
amino acids; lactate
31
. In the liver, pyruvate can be oxidized as fuel in the TCA cycle, or can be _____.
used to make glucose in a | process called gluconeogenesis
32
If the liver does not have enough raw materials to make much pyruvate, both gluconeogenesis and the TCA cycle slow down, and levels of _____ increase.
acetyl-CoA from fatty acid | oxidation
33
If the liver has more acetyl-CoA (from fatty acid oxidation) than it does pyruvate, it uses the extra to make "_____" which the liver secretes into the blood. From there they reach the many tissues of the body, including the brain, that can _____.
ketone bodies; use them as fuel
34
After a(n) _____, blood levels of 'ketone bodies' are ~ 0.12 mM.
overnight fast
35
After a(n) _____, blood levels of 'ketone bodies' are ~ 7 mM.
two week fast
36
In _____, blood levels of 'ketone bodies' are often ~ 23 mM.
diabetic ketoacidosis
37
The production of 'ketone bodies' is _____ in healthy individuals even during a fast, and levels are not allowed to increase enough to _____.
tightly regulated; alter the blood’s | pH
38
In diabetic ketoacidosis, production of 'ketone bodies' is _____ and blood pH _____. This leads to coma and death, unless _____ is administered.
uncontrolled; falls; insulin
39
Proteins which are no longer needed are _____, and these in turn are catabolized.
hydrolyzed to amino acids
40
When an amino acid is to be catabolized, the amino groups are converted to _____ and then to _____ in the liver.
ammonia; urea
41
When an amino acid is to be catabolized, after removal of the amino group, the remaining “keto acid” is altered to allow it to enter the _____ (the point of entry depends on the identity of the amino acid).
citric acid cycle
42
What the body cannot store, it must metabolize, either using it for energy or converting it to a storable form. Alcohol, for example, cannot be stored. Such nutrients are called '_____.'
obligate fuels
43
Alcohol cannot be stored, and an alcoholic drink with a meal results in temporary _____ as the alcohol is used.
storage of the macronutrients | ingested in the meal
44
Protein that is not needed for repair or growth is generally _____ or _____.
used for energy; converted to | carbohydrates or fat
45
In times of rapid weight gain excess protein is stored as extra muscle, but this process is so energetically demanding that it occurs only in the presence of _____ and is usually accompanied by a large fat deposition.
very high caloric intakes
46
Adaptations to increased or decreased ratios of fat to carbohydrate occur _____.
within days
47
Adaptations to changes in protein intake occurs after _____, and an abrupt decrease in dietary protein from accustomed levels can lead to a negative nitrogen balance as required amino acids are _____.
weeks; catabolized for fuel
48
_____ is the most easily stored macronutrient, and excess Calories will result in _____ from the extra food being preferentially stored.
Fat; fats
49
The major macronutrients and many of their constituents (the non-essential amino acids, and many types of fatty acids) can be enzymatically altered to _____.
convert one to another
50
Most (although not all) nutrient inter-conversions occur in the _____, and this is one of its primary tasks.
liver
51
Because of the amount of water needed to solubilize it, glycogen occupies a great deal of space and is quite heavy per Calorie stored. Thus, only _____ can be stored.
a few days’ worth
52
Once glycogen stores are full, excess carbohydrate is converted into a(n) _____ in a process called _____.
16 carbon saturated fat; | lipogenesis
53
As glycogen stores are depleted, or when protein intake is excessive, the liver, kidney, and muscles use amino acids, lactic acid, or glycerol from fats to build new glucose from in a process called _____.
gluconeogenesis.
54
For several hours after eating, the body is in an _____ state, during which its needs for energy and raw materials for anabolic processes are met by _____.
absorptive; nutrients being | absorbed by the intestines
55
Once the intestines are empty the body enters the _____ state.
post-absorptive
56
During the post-absorptive state, energy needs are met by _____.
drawing on stored fuels
57
During the post-absorptive state, raw materials for anabolic processes are obtained by _____: that is, existing molecules are catabolized and their component parts used to build new molecules that may be needed.
recycling existing molecules
58
_____ is the energy used at rest. In a typical individual, it is a bit more than half of our daily energy usage.
Basal metabolic rate
59
_____ is the basal metabolic rate, plus any energy used to _____ or _____. (The need to burn energy to digest food is called the thermic effect of food.)
Total metabolic rate; digest food; | perform work
60
Muscle tissue, even at rest, is metabolically expensive: the greater its mass, the higher the _____.
basal metabolic rate
61
Muscle adds strength, which allows more work to be performed per _____, and thus an increase in muscle mass leads to an increase in calories burnt during exercise or work.
hour OR minute
62
Metabolic processes generate heat as a(n) _____. This is the source of our body’s warmth.
waste product
63
A precise body temperature is maintained by adjusting _____, _____, _____, and _____. These events are overseen and controlled by the _____.
BMR; surface blood flow; sweat production; muscle tension (shivering); hypothalamus
64
Basal metabolic rate is largely controlled by the _____, which among other things alter the amount of “wasteful” ion transport across cellular membranes.
thyroid hormones