Digestive System- Physiology Flashcards
_____means simply ‘eating or drinking,’ while _____ refers to the process of eliminating
_____ (material which is left over after all usable substances have been extracted).
Ingestion; defecation; feces
_____ is the breakdown of ingested foods into simple organic molecules.
Digestion
_____ refers to the mixing of food and digestive juices into a soft pulp.
Mechanical digestion
________ means ‘chewing.’ It is one means by which _____ occurs.
Mastication; mechanical
digestion
Smooth muscles in the gastrointestinal tract are responsible for the _____ of food from
mouth to anus via processes called _____ (swallowing) and _____.
propulsion; deglutition;
peristalsis
_________ consists of a series of progressive, alternating contractions of smooth muscle rings
which encircle the intestine. The result is propulsion of a portion of the partially digested
food, called a(n) _____, through the intestine.
Peristalsis; bolus
Mechanical digestion is continued throughout the gastrointestinal tract via a process
called _____, in which the bolus is rhythmically divided into ever-smaller portions by
bidirectional, peristalsis-like contractions of smooth muscle.
segmentation
_____ of enzymes and corrosive liquids, as well as mucus to lubricate and protect the
system itself is the function of specialized cells within the gastrointestinal tract and
accessory organs.
Secretion
_____ of nutrients is possible because cells of the gastrointestinal tract actively
transcytose them into the blood or lymph.
Absorption
The epithelial cells of the GI tract are joined by _____ so that nutrient molecules cannot
enter the body by passing between cells, but must instead pass through them.
tight junctions
During _____, complex molecules are separated and hydrolyzed by enzymes, emulsifiers
and corrosive chemicals.
chemical digestion
Digestive activity is subject to _____ and _____ controls. These, in turn, are triggered by
_____ or _____ stimuli.
nervous; hormonal; chemical;
mechanical
Neural networks found in the entrails, as a group, are the _____ or _____.
enteric plexus; enteric nervous
system (ENS)
Neural control is primarily _____, via the _____, with only minor modulation from the CNS.
local; enteric plexus
Neural regulation of the digestive system is complex, and involves over 30 _____, each
mediating a slightly different response from the cells which receive them as signals.
neurotransmitters
Many of the hormones that control digestion are produced by _____. This allows each
region of the digestive system to interact with _____, even those some distance away.
cells of the digestive system; all
of the others
Beginning with the esophagus, the GI tract has four major walls or layers, called _____.
From the lumen outward, the first three are the _____, _____, and the _____.
tunics; mucosa; submucosa;
muscularis
The outermost tunic of the GI tract is called the _____ when it is adjacent to the peritoneal
cavity, or the ____ in regions where it is physically continuous with surrounding tissue.
visceral serosa; adventitia
The mucosa of the intestinal tract consists of three layers: from the lumen outward, they
are the _____, _____ and _____.
mucous epithelium; lamina
propria; muscularis mucosae
In many regions of the GI tract, the mucous epithelium invaginates, penetrating the _____
to form _____.
lamina propria; glands
Blood vessels and lymphatic vessels in the _____ of the GI tract’s
mucosa provide nutrients and oxygen, and remove wastes, from the mucous epithelium.
lamina propria
The mucosa-associated lymphoid tissue (MALT) is found in the _____ . Since it is in the gut, MALT in this region is often called “_____”
instead of MALT.
lamina propria; Gut-Associated Lymphoid Tissue (GALT)
The purpose of the MALT in the GI tract is to protect it from _____.
bacteria which contaminate
food or drink
Smooth muscles in the _____ create
transient wrinkles which decrease adherence of substances to the intestinal surface and
increase local mixing.
muscularis mucosae
Most blood vessels, lymphatic vessels, and nerve fibers of the GI tract are found in the
_____ .
submucosa
The inner layer of the muscularis consists of smooth muscle fibers which _____ the
lumen, while in the outer layer the fibers are arranged _____.
encircle; longitudinally
In the stomach and intestines, peristalsis and segmentation are accomplished by
alternating contractions of the inner and outer layers of the _____ .
muscularis
_____ cells in the muscularis control the rate of peristalsis and segmentation.
Pacemaker
In certain regions of the GI tract, the muscles of the muscularis act as _____, and are
capable of closing to prevent movement of food or liquid through the tract.
sphincters
Neurons of the enteric plexus in the submucosa are called the _____ plexus; those in the
muscularis lie _____ and are called the _____ plexus.
submucosal; between the
muscle layers; myenteric
The mouth is kept moist between meals primarily by the _____, which are scattered
throughout the oral mucosa.
intrinsic salivary glands OR
buccal glands
When we ingest food (or even think about it!) signals from the _____ branch of the
autonomic nervous system cause the _____ salivary glands to produce saliva.
parasympathetic; extrinsic
Damage to _____ can prevent signals from the CNS from reaching the salivary glands
and increasing salivation.
cranial nerves VII or IX
_____ and _____ respond to taste and pressure, and lead to an increase in salivation that
is mediated by the autonomic nervous system.
Chemoreceptors;
pressoreceptors
The _____ branch of the autonomic nervous system inhibits production of serous (watery)
saliva, but not of mucin-rich saliva, so that stress leaves the mouth feeling dry and sticky.
sympathetic
Saliva contains amylase to begin _____, chemicals including lysozyme and immunoglobin
A to _____, and mucin to _____.
starch digestion; inhibit
bacterial growth; lubricate the
mouth
The two major processes which moisten and soften food in the oral cavity are _____ and
_____.
mastication; salivation
_____ means ‘swallowing.’
Deglutition
The voluntary portion of deglutition is the _____ phase, which occurs in the mouth. In this
phase, the _____ is used to push the food into the _____.
buccal; tongue; oropharynx
The second phase of deglutition, the _____ phase, is involuntary.
pharyngeal
During the pharyngeal phase of deglutition, the _____ prevents food from returning to the
mouth.
tongue
During the pharyngeal phase of deglutition, the _____ and _____ prevent food from
entering the nasopharynx.
soft palate; uvula
During the pharyngeal phase of deglutition, the _____ prevents food from entering the
larynx.
epiglottis
Cranial nerves V, IX, X and XI are all involved in the _____. Damage to any of them can
make it difficult to swallow.
pharyngeal phase of deglutition
Three rings of muscles in the pharynx called the _____ contract one after the other to
propel food into the esophagus.
pharyngeal constrictor muscles
As food reaches the bottom of the pharynx, the _____ relaxes.
upper esophageal sphincter
During the third phase of deglutition, the _____ phase, food is propelled toward the
stomach by _____ .
esophageal; peristalsis
Both the pharyngeal and esophageal stages of deglutition are triggered by _____ and
lead to both local and CNS signals.
contact with solids or liquids
OR tactile receptors
Since the task of the esophagus is simply to transport food, its surface is optimized for
resisting friction as food passes by; it consists of _____.
stratified squamous epithelium
The surface of the esophagus includes _____ glands, which lubricate the surface.
mucous or esophageal
Mixing semi-solid food with liquid to form completely liquid ‘_____’ is one of the major
functions of the _____.
chyme; stomach
Liquid is secreted into the stomach by _____; their entrances, the _____, appear as pores
on the stomach’s interior surface.
gastric glands; gastric pits
Unlike the esophagus, whose surface is specialized to resist friction, the surface of the
stomach is specialized for _____, and consists of _____.
secretion; simple columnar
epithelium
Gastric secretions and food are mixed in the stomach by muscular contractions called
_____. These contractions occur primarily in the _____, the widest part of the pyloric region.
mixing waves; antrum
Unlike the muscularis in other regions of the GI tract, that of the stomach has _____.
three layers
The stomach adjusts to the ingestion of food or drink by _____ and _____ to
accommodate to the new demand for volume.
stretching; relaxing
While most digestion occurs in the _____, digestion of _____ begins in the stomach.
small intestine; protein
_____ cells in the gastric glands secrete a(n) _____ (an inactive proenzyme) called
pepsinogen.
Chief; zymogen
Pepsinogen, when it is placed in a(n) _____ environment, is activated to form the enzyme
_____. This enzyme hydrolyzes _____.
acidic; pepsin; proteins
_____ cells in the gastric glands secrete hydrochloric acid, which _____ the pH in the
stomach’s lumen.
Parietal or Oxyntic; lowers
Hydrochloric acid _____ proteins and nucleic acids in the stomach and converts _____ to
its active form, _____.
denatures; pepsinogen; pepsin
Most bacteria are unable to survive in the stomach because of the _____.
low pH OR acidity
The parietal cells use _____ acid as the source for positive hydrogen ions. This produces
the negative _____ ion, which they don’t need or use.
carbonic; bicarbonate
To get rid of bicarbonate ions, parietal cells secrete it into the blood, exchanging it for the
readily available _____.
chloride ions
The stomach’s secretions must be electrically neutral, and so the secretion of positive
hydrogen ions into the lumen is accompanied by the secretion of negative _____.
chloride ions
In water, hydrochloric acid is present as two ions: _____ and _____.
hydrogen ions; chloride ions
The two major cell types in the stomach produce _____, which is necessary so that the
stomach does not _____.
mucus; digest itself
The mucus that coats the stomach is thick, heavy, and (just as importantly) _____. This is
because the mucus producing cells mix their product with _____.
neutral to alkaline; bicarbonate
Very few substances are absorbed in the stomach - most cannot penetrate the _____
layer. Those that can include water, alcohol, and a few drugs.
mucus
Vitamin B12 would be destroyed by the stomach’s acid if not for _____, a protective
glycoprotein secreted by _____. (B12 is critical for DNA replication: the first symptom of
deficiency is _____ due to poor cell division.)
intrinsic factor; parietal cells;
pernicious anemia
_____ is needed not only to protect vitamin B12 from destruction in the stomach, but also
to allow it to be absorbed in the intestine. Thus, production of this glycoprotein by the
stomach is absolutely critical to survival.
Intrinsic factor
Three chemicals together signal the parietal cells to secrete HCl: _____, _____ and _____.
gastrin; histamine; acetylcholine
Gastrin is released by enteroendocrine cells in the stomach mucosa in response to _____
or to signals from the _____.
an increase in stomach
content; CNS
Gastrin has several effects, one of which is to promote _____ in the cells of the stomach:
thus, in the long term, a large appetite leads to a large _____. (Do not confuse this with a
large store of fat in the abdomen, which may also occur!)
cell division; stomach