metabolism Flashcards

1
Q

Metabolism

A

the sum total of all the chemical
reactions occurring in an organism

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2
Q

Remember the 2nd law of thermodynamics

A

– In a closed system the direction of change is
toward disorder
– Animals are an open system
* They require energy to maintain order in
their bodies

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3
Q

Two Metabolic pathways

A

anabolic and catabolic

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4
Q

Anabolic

A

– Assembling of substances into complex
molecules
– Requires energy
– Net incorporation of N-containing molecules by
protein synthesis

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5
Q

Catabolic

A

– Breakdown of complex energy-rich materials
into simpler molecules
– Releases chemical energy
– Some energy stored as ATP or glucose

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6
Q

Three forms of energy

A

– Chemical
* Freed/needed for atom reconfiguration
– Electrical
* Charge separation of molecules
– Motional
* Mechanical
– Energy of organized motion
* Heat
– Formed by random motion of all molecules

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7
Q

Work and Physiological work

A
  • Work- the transfer of energy from one source
    to another
  • Physiological work- any process carried out by
    an animal (or plant) that increases order in the
    environment (internal and external)
    – Breakdown of molecules
    – Bodily movements
  • Heat generation is NOT physiological work
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8
Q

Heat

A
  • Can only convert heat to work if there is a temperature
    discrepancy within the system
    • Internal combustion engine propels a car
  • Heat is important to organisms and MR
  • Energy forms and heat
    – High-grade energy- can perform phys. work
    * Chemical, electrical, mechanical
    – Low-grade energy- cannot perform phys. work
    * Heat
    * Degrade energy when convert from high to low
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9
Q

Animal energy use

A
  • Ingested energy- chemical bonds of food
    – Food unable to be digested- Fecal energy
    – Food assimilated into body- Absorbed energy
  • Absorbed energy has 3 routes
    – Biosynthesis
    – Maintenance
    – External work
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10
Q

note to self, study what is happening on the uses of energy by an animal image

A

page 2 slide 3 on page

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11
Q

Biosynthesis

A
  • Synthesis of body proteins and lipids
    – Accumulation of chemical energy in body
    tissues- during growth
    – Also during fat storage
    – Eventually eaten or die (decompose)
  • Some synthesized chemicals are exported
    – Gametes, milk, excreted mucus, skin, hair, etc.
  • Some energy lost as heat
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12
Q

Maintenance

A
  • Maintain integrity of the organism as a whole
    – Internal work
    • Circulation, respiration, gut motility, etc.
  • Very costly to the organism
    – Almost all of the high-grade energy is degraded
    to heat
    – Every step of ATP use causes additional
    degradation
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13
Q

External work

A
  • Mechanical work performed outside the body
    – Necessary events to be biologically successful
    • Food, sex, and practicing for both!
  • Some of this energy is degraded to heat (ATP)
  • Some is transferred outside of the body where
    it ultimately finds the same fate
    – Resistance to motion (heat)
    – Potential energy followed by resistance (heat)
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14
Q

All animals create heat

A
  • Think about the diagram
    – Most of the absorbed energy becomes heat
    – Are endothermic organisms unique?
  • The pathway is one-way
    – Not possible to convert heat into high-grade
    energy
    – Energy is not recycled
    * Explains why animals require continued
    consumption throughout their lives
  • Collective heat from all organisms radiates into space
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15
Q

Metabolic rate

A

– Conversion of chemical energy into heat
– Expressed as heat energy released per unit
time, rate of heat production
– Determines how much food is needed
– Representative of an animal’s lifestyle/intensity
– Measures an organism’s drain on the
ecosystem by degradation of chemical energy

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16
Q

Measurement of metabolism

A
  • Direct calorimetry
    – Measurement of energy released as heat over a given
    period
  • Indirect calorimetry
    – Measures metabolism from food intake and waste excretion
    • Respirometry
      – Rate of gas exchange with the environment
    • Material balance
      – Measure chemical energy of organics that enter
      and leave the body
  • Radioisotopes (in vivo)
    – Inject radioisotopes of O2 and H, then measure loss of body water with respect to loss of O2
17
Q

not all food is equal

A

The heat produced from catabolism differs with the
food item. Carbs are the cheapest, proteins are the middle, and lipids are the most expensive.

18
Q

Respiratory ratios

A
  • Respiratory exchange ratio (R) and respiratory
    quotient (RQ) are often used interchangeably
    – Not always correct, but often is
    RQ= O2 consumed per unit time/ CO2 produced per unit time
19
Q

Factors affecting metabolic rate
Note: look at the slide and study what the effects are.

A

– Age/gender
– Amount of lean muscle
– Physical activity level
– Diet
– Hormones

20
Q

Absorptive (fed) state

A

– Ingested nutrient molecules enter the blood
– Some are used to supply various needs of the
body
– Net synthesis of proteins, glycogen, and fat

20
Q

Post-absorptive (fasted) state

A

– Digestive tract is empty of nutrients
– Available pool of nutrients in blood decreases
– Net degradation of proteins, glycogen and fat

20
Q

Homeotherm vs. poikilotherm

A
  • Basal Metabolic Rate (Homeotherms)
    – In Thermal Neutral Zone
    – Fasting (postabsorptive)
    – Resting
  • Standard Metabolic Rate (Poikilotherms)
    – Fasting
    – Resting
  • BMR/SMR- Stable rate of energy metabolism
    under conditions of minimum environmental and
    physiological stress and after fasting
21
Q

Temperature and hormones involved

A

Q10 = R2/R1^(10/(T2-T1) enzymatic activity by time
10 degree increase causes a 2-3 times increase of enzymatic activity.
– Insulin
– Glucagon
– Epinephrine
– Glucocorticoids
– Growth hormone
– Thyroid hormone

22
Q

Body size: Does metabolic rate increase
proportionally

A

meadow vale consumes 175 grams of food and weighs 30 grams, and a white rhino consumes 650 kg of food and weighs 1900 kg. vale has a higher metabolic rate than rhino

23
Q

Factors influencing
metabolic rate

A

Body size-
smaller animals
respire at higher
metabolic rates
per unit body
mass than larger
animals

24
Q

MMR

A
  • Maximum Metabolic Rate
    – Exercise induced metabolic rate
    – Approximately ten times BMR or SMR
  • Exponent difference between BMR and MMR
    – M (metabolic rate) = a Wb
    – 0.7 for BMR
    – 0.85 for MMR
25
Q

Locomotion

A
  • The amount of energy required (beyond BMR)
    to move a unit of mass of an animal a unit
    distance (kcal/kg/km)
  • Small animals use more energy to achieve a
    given velocity of locomotion than larger animals
26
Q

Who cares?

A
  • These relationships are allometric
  • Relationship between two characters
  • Nonlinear relationship between metabolism
    and body mass
  • Ventilatory rate and heart rate allometric
  • Ecological: pop biomass/sq km func of size
  • Size and pollutants: sm size accum more
27
Q

Heart rate proportions

A

Heart size in mammals is roughly proportional to body size, but heart rate is not the same.

28
Q

Explanation for allometry

A
  • Surface area to volume theory
    – As a sphere increases in volume by 1, surface
    area increases by 2/3
    – Applies to animals
    • Big animals have proportionally smaller surface
      area per volume
    • Small animals have more surface area and lose
      more heat
  • Data don’t always support the theory- SA/V is still
    important
  • Does not apply to poikilotherms
29
Q

Energetics of Food and Growth

A
  • One organisms growth is another’s food
  • Energy value/unit weight
    – Fat has at least twice as much energy (per unit)
    more than proteins and carbohydrates
    – Fat is the most energy dense substrate
    • Important in all migrating species
  • Must consider the absorption efficiency of the
    food item
30
Q

Energetics of Food and Growth Cont

A

Energy abs. efficiency =
Absorbed energy
Ingested energy
Gross growth efficiency =
Chem. bond energy growth
ingested energy
Net growth efficiency =
Chem. bond energy added
absorbed energy

31
Q

Is growth efficiency always constant?

A
  • Declines with age
  • Consideration in agriculture/aquaculture