Metabolics Flashcards
Child presents to outpatient clinic with severe ID, hyperactivity, widely spaced teeth with enamel hypoplasia and gets teased at school for smelling musty. Normal at birth and started regressing at a few months of age. Dx?
Phenylketonuria
Mx of PKU?
Low phenylalanine diet
Large neutral amino acid supplements (competes against phenylalanine for transport)
Child presents with fever, vomiting, myalgia and hypotonia of the trunk and neck. On exam tender hepatomegaly and smells like cabbage. VBG shows acidosis with hypokalaemia and hypochloraemia and low glucose. LFTs transaminase derangement. What dx?
Tyrosinaemia Type 1/ Hereditary Tyrosinaemia
Investigation of choice for tyrosinaemia?
Serum and urine succinylacetone
Management of tyrosinaemia?
Low phenylalanine and tyrosine diet
Nitisone (competitive enzyme inhibitor)
Tall, lanky, dev delayed child presents with ectopia lentis. What dx?
Homocysteinuria
Pathophysiology of homocysteinuria?
Inborn error of methionine metabolism
Ix for suspected homocysteinuria?
Plasma total homocysteine level
Methionine level
Genetic test (mutation in CBS gene)
Management of homocystenuria?
High dose B6 (60% responsive) and folate supp
Methionine restricted diet
Infant brought into ED D4 of life with poor feeding, lethargy and admitted for observation. Hypertonic and back arching with slow writhing limb movements, then had a seizure.
Normal glucose, normal ammonia and normal VBG but urine dip has ketones +++. What dx?
Maple syrup urine disease
What further ix if suspected MSUD?
DNPH testing of urine
Plasma brach chain amino acids (raised)
Urine alpha-hydroxyacids and alpha-ketoacids (raised)
School age child presents with severe ketoacidosis, currently being treated w amoxil by GP for pneumonia. Rapidly deteriorates with ataxia, lethargy and has a seizure. What dx?
Intermittent Maple Syrup Urine Disease
Management of MSUD?
Diet low in BCAAs - reduce natural protein, BCAA free formula for infants
Dialysis to remove metabolites
Liver transplant
2week infant with sepsis like illness and metabolic acidosis with widened anion gap and high ammonia level, pancytopenia. What family of metabolic diseases?
Organic acidaemias
Treatment principles for organic acidaemias?
Low protein diet
Enhance enzyme activity w B12/biotin
Carnitine supp - binds to organic acids for excretion
Child with sweaty feet and episodes of vomiting, ketoacidosis and neutropenia/thrombocytopenia?
Isovaleric acidaemia
Cause of isovaleric acidaemia?
Deficiency of isovaleryl coenzyme A dehydrogenase
Week old infant with ketoacidosis and lethargy?
Proprionic acidaemia
Cause of proprionic acidaemia?
Proprionyl co-A carboxylate deficiency
Newborn with microcephaly, retinopathy, hydrocephalus. Metabolic acidosis on gas with high anion gap. Organic acids in urine?
Methylmalonic acidaemia
Treatment for methylmalonic acidaemia?
High dose B12
Suppress enzyme producing bacteria in GIT - metronidazole
Biotin (propionic acid)
4mo infant presents with developmental regression, seizures, progressive head enlargement. MRI B demonstrates diffuse subcortical and periventricular white matter abnormalities?
Canavan disease (aspartic acidaemia)