Metabolic Syndrome & D Insipidus

Question 1

Metabolic syndrome

• define
• risk factors

Answer 1

Group of 5 risk factors that incr the likelihood of developing heart disease, diabets, stroke

Incr BP
High BS levels
Excess fat around waist
High triglyceride levels
Low HDL

Question 2

Diabetes Insipidus

• define
• cause

Answer 2

Syndrome characterized by production of large amounts of dilute urine

Deficiency of vasopressin (AVP/ADH) secretion/action

Question 3

Diabetes Insipidus

-clinical characteristics

Answer 3

Decr of 75%+ in secretion/action of vasopressin

Question 4

Diabetes Insipidus

-etiology

Answer 4

Primary deficiency of vasopressin secretion usually due to irreversible destruction of neurohypophysis

Pituitary DI due to surgery in/around neurohypophysis

Question 5

Diabetes Insipidus

-treatment

Answer 5

Desmopressin (DDAVP) = synthetic vasopressin analogue

Acts selectively on V2 receptors -> incr urine concentration, decr urine flow

• dose-dependent
• more resistent to degradation than vasopressin, 3-4x duration of action