Metabolic Syndrome

Question 1

What is metabolic syndrome defined as?

Answer 1

Defined by interconnected physiological, biochemical, clinical, and metabolic factors that increases the risk of CV disease and type 2 diabetes mellitus

Question 2

What causes it metabolic syndrome?

Answer 2

It’s a consequence of complex interplay between genetic (eg polymorphisms in genes affecting lipoprotein metabolism etc) and environmental (eh physical inactivity, smoking, stress, etc) factors

Question 3

What cells make up adipose tissue?

Answer 3

A mix of adipocytes, stromal pre-adipocytes, immune cells, and epithelium

Question 4

What does adipose tissue rapidly respond to?

Answer 4

Alterations in nutrient excess through adipocytes hypertrophy and hyperplasia

Question 5

What result does reduced blood supply to adipocytes have?

Answer 5

Contributes to necrosis and macrophage infiltration into adipose tissue

Question 6

What processes do adipocytokines mediate?

Answer 6

Insulin sensitivity; oxidant stress; energy metabolism; blood coagulation; inflammatory responses