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Pathobiology of Human Disease > Alzheimer's > Flashcards

Alzheimer's Flashcards

1
Q

What are AD’s pathological hallmarks?

A

Extracellular deposits of beta amyloid protein (Aß)
Amyloid plaques
Intracellular neurofibrillary tangles (NFT)
Hyperphosphorylated tau protein

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2
Q

What are the hypotheses of AD pathogenesis?

A

Amyloid cascade
Tau and tangle
Cholinergic
Mitochondrial dysfunction/oxidative stress

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Pathobiology of Human Disease (12 decks)

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