Metabolic Pathways Flashcards
state the 2 types of Metabolic reactions
anabolic
catabolic
describe anabolic reactions
build up large molecules from small molecules, which requires energy
describe catabolic reactions
break down large molecules into smaller molecules, which releases energy
what controls the Metabolic pathway
by the presence or absence of a particular enzyme and the regulation of the rate of reaction of key enzymes
what is a Metabolic pathway
integrated and controlled pathways of enzyme catalysed reactions within a cell
what can Metabolic pathway do
be reversible
be irreversible
alternative routes
what is an induced fit
when the active site changes shape to better fit the substrate after the substrate binds
what does a substrate have for the active site
high affinity
what do products have for the active site
products have a low affinity allowing them to
leave the active site
what determines the direction if the reaction
presence of a substrate or the removal of
a product will drive a sequence of reactions
in a particular direction.
state 3 types if inhibitirs
competitive
non competitive
feedback
describe competitive inhibition
Competitive inhibitors bind at the active site
preventing the substrate from binding.
Competitive inhibition can be reversed by
increasing substrate concentration.
describe non competitive inhibition
Non-competitive inhibitors bind away from
the active site but change the shape of the
active site preventing the substrate from
binding. Non-competitive inhibition cannot be
reversed by increasing substrate
concentration
describe feedback inhibition
Feedback inhibition occurs when the endproduct in the metabolic pathway reaches a
critical concentration. The end-product then
inhibits an earlier enzyme, blocking the
pathway, and so prevents further synthesis of
the end-product.
