Metabolic medicine

Question 1

Basic pathophys of haemochromatosis

Answer 1

disorder of iron aborption and metabolism = iron accumulation

Question 2

Fts of haemochromatosis
1- early
2- reversible complications
3- irreversible complications

Answer 2

1- asymptomatic; fatigue, erectile dysfunction, arthralgia (hands)
2- bronze skin pigmentation; cardiomyopathy (but progress to cardiac failure - 3); chronic liver disease with hepatomegally (but progress to cirrhosis or hepatocellular deposition - 3)
3- DM; hypogonadotrphic hypogonadism (cirrhosis + pituitary dysfunction); arthritis