Metabolic Disorders Of Bone Flashcards
What is the annual rate of turnover of trabecular and cortical bone?
25% trabecular
4% cortical
What type of bone is mainly lost in women following menopause?
Trabecular bone
What is the rate of bone loss in women after menopause?
2-3% per year
What condition can cause high bone mass?
Osteopetrosis
What condition can cause low bone mass?
Osteoporosis
Osteogenesis imperfecta
What conditions can result from loss of mineralisation of bone?
Rickets
Osteomalacia
What diseases can cause high bone turnover?
Pagets disease
Hyperparathyroidism
Thyotoxicosis
What diseases can cause low bon turnover?
Adynamic disease
Hypophosphataemia
What are the features of hyperparathyroidism?
Hypercalcaemia
Increased bone turnover
Subperiosteal bone resorption
Generalised decrease in bone density
What are the features of pagets disease?
Both bone formation and resorption are increased leading to disorganised structure of bone, reduced bone strength, increased risk of fracture and a link to osteosarcoma tumour suppressor gene
What is fluorosis?
Abnormal mineralisation of bone where calcium is replaced by fluoride in the matrix
Osteopetrosis is a genetic disorder where there is a failure of osteoclastic and chondroclastuc resorption. T/F?
True
