Metabolic disorders

Question 1

what is acute porphyria?

Answer 1

a heredity disorder of harm biosynthesis 1 in 75000
characterized by a deficiency of hydroxymethylbilane synthase (HMBS). It presents with abdominal pain, nausea, vomiting, peripheral neuropathy, and seizures. Treatment for acute attacks is intravenous heme.

Question 2

what was the treatment for moderate- severe acute porphyria crises?

Answer 2

IV haem arginate administered

Question 3

what are the main drugs that can cause acute porphyria crises?

Answer 3

amiodrone
carbamaepine
chloraphenicol
clindamycin
diltizem
erythromycin
indapmide
methyldopa
nitrofurantoin
pheytoin
rifampicin
risperidone
spironolactone
tamoxifen
topiramate
trimethoprim
valporate
veramil