Metabolic Disease & the Maxillofacial Complex Flashcards
What is metabolic disease?
any disruption of the ability to the cell to perform critical biochemical reactions involved in the converting food to energy on a cellular level
Thousands of enzymes participate in dozens of _________ metabolic pathways
interdependent
Are metabolic disease heritable?
typically yes
Do all metabolic diseases present the same?
no, they differ and in some cases appear only when the body is stressed
What is typically affected by metabolic disease?
bone/mineralized tissue and cartilage
what stages of life are affected by metabolic disease?
all!
infancy–> reflects an impact on embryo/fetus
adolescence–> hormonal influence
adult–> can be due to lifestyle
What are some factors that can influence metabolic disease?
genetics, nutrition, gender, age, environment, cultural, occupation, and other diseases/co-morbidities
how do genetics influence metabolic disease?
genes encode for the enzymes that regulate the pathways
how does nutrition influence metabolic disease?
vitamins form precursors to metabolic pathways
What are some of the things that can be screened for in newborn screening?
Phenylketonuria (PKU), hypothyroidism, galactosemia, sickle cell disease, and cystic fibrosis
What is a benefit for newborn screening?
allow for early treatment or dietary intervention to prevent/manage/delay symptoms
What is protein glycosylation?
sugar trees (glycans) are created, altered, and chemically attached to certain proteins or fats
-one of the major post-translational modification
-impacts protein folding, distribution, stability, and activity
How many genes are in the human genome?
20,000-25,000
How many tRNAs can be made with modifications?
over 100,000
*due to large variability in pattern of glycosylation
What are 5 types of protein glycosylation?
N-glycosylation**
O-glycosylation**
Glypiation
C-glycosylation
Phosphoglycosylation
What determines the pattern of glycosylation?
the cell type or tissue type
Why does glycosylation change based on the tissue type?
Different genes are active in different tissues
N-linked glycosylation
amide bond formed between N-acetylglucosamine and the Asparagine (N)
*typically see attached to two blue boxes
Where does N-linked glycosylation occur?
endoplasmic reticulum