Mental Health N4615 Module II Flashcards

1
Q

What is Schizophenia Spectrum?

A

It, and other psychotic disorders are those that distrub the fundamental ability to deteremine what is real or what is not.

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2
Q

All people who have Schizophrenia, have at least one of the following psychotic symptoms

A

hallucinatioins

delusions

and / or disorganized speech

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3
Q

What is the epidemiology of Schizophrenia

(when does it normally occur)

A

usually presents in late teens / early twenties.

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4
Q

What are the prodromal signs of schizophrenia

A

they are the initial signs indicating that a pt. might be leading toward a schizophrenic break

Withdrawal

misinterpreting

poor concentration

preoccupation with religion

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5
Q

What is early on-set Schizophrenia

A

(18 to 25) occurs more often in males

associated w/poor functioning before onset & more structural brain damage

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6
Q

What is later on-set Schizophrenia

A

(25 to 35) more likely to be female

less structural brain damage

better outcomes

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7
Q

What are some of the comorbidities associated w/ Schizophrenia

A

1) Substance abuse disorders - nearly 50% (sucide)
2) Nicotine dependence 70% - 90%
3) Anxiety, depression
4) Physical Health Illnesses

5) Polydipsia - can lead to fatal water intoxication (20% have insatiable thirst) may be due to medications

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8
Q

What is the etiology of Schizophrenia

A

scientific consesus is that Schizophrenia occurs due to multiple inherited genetic abnormalities combined with nongenetic factors.

called the diathesis-stress model of Schizophrenia

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9
Q

What are some of the genetic factors for Schizophrenia

A

Increased levels of dopamine (1st generations treat)

Increased levels of serotonin (2nd generation meds treat)

glutamate - which is a major neurotransmitter during neuronmaturation

Brain Structure Abnormalities - reduced volume of “grey matter” (temporal / frontal lobes) — more hallucinations.

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10
Q

What are some of the psychological / environmental

factors associated w/ Schizophrenia

A

1) prenatal stressors (poor nutrition & hypoxia)
2) psychological stressors (stress w/ incr cortisol level which imped hypothalamic development)
3) environmental stressors (toxins, ie. solvent tetrochoroethylene in dry cleaning)

all increase chances w/ those vulnerable to Schizophrenia

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11
Q

Schizophrenia def.

A

The most severe form of Schizphenia Spectrum

It is a potentially devastating brain disorder that affects a person’s thinking, language, emotions, social behavior, and ability to perceive reality accurately.

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12
Q

What are the Phases of Schizophrenia

A

Phase I - Acute

Phase II - Stabilization

Phase III - Maintenance

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13
Q

Def. Phase I - Schizophrenia

A

Acute

onset or exacerbation of distruptive symptoms (ie. hallucinations, delusions, apathy w/draw)

w/ loss of functional abilities - increased care or hospitalization may be required.

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14
Q

Def. Phase II - Schizophrenia

A

Stabilization

symptoms are diminishing, and there is movement towards one’s previous level of functioning (baseline)

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15
Q

Def. Phase III - Schizophrenia

A

Maintenence

pt. is at or near baseline functioning

symptoms are absent or significantly decreased.

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16
Q

What are the 4 main symptom groups of Schizophrenia

A

Positive symptoms

Negative symptoms

Affective Symptoms

Congnitive Symptoms

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17
Q

What are postive symptoms of Schizophrenia

associated w/acute onset

A

The presence of something that is not normally present

hallucinations

delusions

disorganized speech

bizarre behavior

will generally respond to medication

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18
Q

What are negative symptoms of Schizophrenia

A

absence of something that should be present

  • Poverty of thought (interest in hygiene)
  • Avolition (loss of motivation / energy or drive)
  • Blunted affect (minimal emotional response)
  • Alogia (poverty of speech)
  • Anhedonia (loss of joy in something previously enjoyed)
  • Anergia (lack of energy)

more presistent / crippling b/c they reduce motivation & limit social & vocational success

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19
Q

What are cogntitive symptoms of Schizophrenia

A

often subtle changes in memory, behavior, attention or thinking

ie. impaired executive functioning (ability to set priorities or make decisions)

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20
Q

What are affective symptoms of Schizophrenia

A

symptoms involving emotions and their expression

dysphoria (dissatisfaction w/ life)

suicidality

hopelessness

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21
Q

Positive symptoms are broken down into

what four categories

A

alterations in

1) thought
2) speech
3) perception &
4) behavior

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22
Q

What is “concrete thinking

A

refers to the impaired ability to think abstractly

ie. When you ask a pt. what brought them to the hospital — they would say “ a cab”

Concreteness reduces one’s ability to understand and address abstract concepts such as love or the passage of time.

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23
Q

What is “clang association

A

choosing words based on their sound rather then their meaning

ie. rhyming “on the track… have a Big Mac”

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24
Q

What is “word salad” (schizohasia)

A

jumbled words that are meaningless to the listener and possible to the speaker

ie. “red chair out town board”

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25
Q

What are Neologisms?

A

made-up words that have meaning to the pt. but a different or nonexistent meaning to others

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26
Q

What are Echolalia

A

pathological repeating of anothers words

ie. Nurse…Mary, come get your medication

Mary…come get your medication

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27
Q

What is Depersonalizaiton

A

feeling that one is somehow different or unreal or has lost his / her identity

may feel body parts don’t belong to them.

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28
Q

What is Derealization

A

a false perception that the environment has changed - surroundings seem strange and unfamilar

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29
Q

What is associative looseness

A

refers to jumbled thoughts inchoherently expressed to the listener.

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30
Q

Illusion is def as

A

A false belief about a perception

Based on a real perception (sight, sound, taste or feeling) that is misinterpreted

ex. the person actually sees something but believes they see something else

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31
Q

Hallucinations are def as

A

Perceptions involving the senses (sight, sound, odor, taste or feeling on the skin)

The body’s ability to detect things in the environment that are not detected by others.

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32
Q

Hallucinations vs. Illusions

both are perceptions

A

Hallucinations involve perceiving a sensory experience for which no external stimulus exist

Illusions are misperceptions or misinterpretations of a real experience (external stimulus); a false belief about a perception

ie. pts see the coat rack, but believes it is a bear

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33
Q

What are the types of hallucinations

experienced by 60% of pts. with Schizophrenia

A

Auditory: hearing voices or sounds

Visual: seeing persons or things

Olfactory: smelling odors

Gustatory: experiencing taste

Tactile: feeling bodily sensations

ex. I see; I hear; I taste; I smell; I feel

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34
Q

What are the worst types of hallucinations

A

Command hallucinations

those that direct pts to take action. voices may command the pt. to hurt themselves or others.

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35
Q

What is the MOST EFFECTIVE intervention for hallucinaitons?

A

Medications

RN-patient relationship

Reduce environmental stimuli

Increase internal stimuli (exercise) - tell the hallucinations to go away…listen to my voice or music

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36
Q

What is “Catatonia

A

pronounced decrease in the rate and amount of movement

Generally pts. may move little if at all

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37
Q

What is Echopraxia

A

mimicking the movements of another

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38
Q

What is Anosognosia

A

inability to realize they are ill (caused by the illness itself)

The resulting lack of insight can make assessment / treatment challenging.

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39
Q

What does the “recovery model” stress

A

stresses hope, living a full and productive life, and eventually recovery rather than focusing on controlling symptoms and adapting to the disability

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40
Q

What is the overall goal for the acute phase

A

patient safety and stabilization

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41
Q

What goals does phase II (stabilization) focus on

A

helping the pt understand the illness and treatment, become stabilized on medications, and be able to control or cope with symptoms.

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42
Q

What goals does phase III (maintenance) focus on

A

adhering to medication, preventing relapse, and achieving independence and a satisfactory quality of life.

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43
Q

What is “waxy flexiblity

A

the ability to hold distorted postures for extended periods of time.

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44
Q

What are some of the signs of a potential relapse in schizophrenia

A

feeling tense

difficultly concentrating

trouble sleeping

increased w/drawal

increased bizarre or magical thinking

Relapse can occur even w/ medication compliance

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45
Q

Delusions are def. as

A

false fixed beliefs that cannot be corrected by reasoning. Pt will agree w/ RN about facts but disagree w/ interpretation.

75% of those w/ schizophrenia experience these

persecutory

gradiose or

those involving religious or hypochondriacal ideas

ex. I think; I believe; I interpret; My opinion

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46
Q

Delusion vs. Illusion

A

A delusion (false belief) does not change w/ the use of logic.

An illusion (false belief about a perception) can often change once a person is given evidence that the belief is not true.

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47
Q

Delusions may be bizarre or non-bizarre

A

Bizarre type are unreal and impossible beliefs

i. e. Pt believes body organs replaced in absence of scars
i. e. Pt believes they are another animal (not human)

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48
Q

Non-bizarre types of delusions

A
  • Delusions of control
  • Ideas of reference
  • Persecution
  • Grandeur
  • Somatic
  • Erotomanic
  • Jealousy
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49
Q

Def. of control delusions

A

Believing that another person, group of people, or external force controls thoughts, feelings, impulses, or behavior

i.e. Pt covers his apartment walls w/ aluminum foil to block government efforts to control his thoughts

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50
Q

Def. of ideas of reference

A

Giving personal significance to unrealated or trivial events; perceiving events as relating to you when they are not

i.e. Pt believes that birds sing when she walks down the street just for her.

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51
Q

Def. of persecution delusions

A

Believing that one is being singled out for harm by others; this belief often takes the form of a plot by people in power.

i.e. Pt believes the Secret Service was planning to kill him by poisoning his food; therefore, he would eat only prepackaged food.

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52
Q

Def. of grandeur delusions

A

Believing that one is a very powerful or important person

i.e. Pt believed he was a famous playwright and tennis pro

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53
Q

Def. of somatic delusions

A

Believing that the body is changing in unusual ways (i.e. rotting inside)

i.e. Pt said his heart had stopped and was rotting away.

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54
Q

Def. of erotomanic delusions

A

Believing that another person desires you romantically.

i.e. Although he barely knew her, Patti insisted that Eric would marry her if only his current wife would stop interfering.

55
Q

Def. of jealousy delusions

A

Believing that one’s mate is unfaithful

i.e. Pt wrongly accused her spouse of going out w other women. Her proof was that he twice came home from work late (even though his boss explained that everyone had worked late).

56
Q

What is paranoia?

A

An unrealistic fear of harm

57
Q

What is the HIGHEST PRIORITY intervention for delusional thinking?

A
  • Reinforce reality for the pt.
  • Establish a relationship or milieu that promotes trust
  • Give meds on time (do not be late w/ prescribed meds)
58
Q

Characteristics of psychotic thinking

A
  • Limited ability to focus when lots of things are happening
  • Concrete thought
  • black/white thinking
  • right/wrong judgments
  • relationship w/ objects
  • ambiguous boundaries btwn reality & fantasy
  • ambiguous boundaries btwn self & others
59
Q

Psychosis key points

A
  • psychosis is frightening to the pt - provide safety
  • use kindness & respect
  • pts experiencing psychosis NEED an anchor to reality
60
Q

Hierarchy of needs for psychosis intervention

A

Priorities will change depending on the situation and context (use critical thinking)

  • Physical integrity
  • Establishing trust
  • Preventing inappropriate behavior
  • Treating symptoms: hallucinations/delusions
  • Enhancing compliance w/ treatment
  • Reinforcing reality
61
Q

What neurotransmitter is targeted by traditional antipsychotics?

A

Dopamine

Traditional antipsychotics block excessive dopamine, an excitatory neurotransmitter, so that symptoms r/t psychosis are reduced.

62
Q

Typical (1st generation) Antipsychotic info

A

Reduce positive symptoms of psychosis

Blocks Dopamine

Uses: quick hallucination remission (delusions take longer to respond); out-of-control aggression; acute manic episodes

Safe, highly effective, very affordable

Poor compliance d/t bothersome SEs (i.e. EPS)

63
Q

Common Typical (1st generation) Antipsychotics

A

Chlorpromazine (Thorazine)

Fluphenazine (Prolixin)

Prochlorperazine (Compazine)

Haloperidol (Haldol)

64
Q

What are common side effects of Haldol (Haloperidol)?

A
  • Sedation
  • Muscle stiffness
  • Akathisia
  • alters effectiveness of exogenous insulin

Antipsychotics often produce sedation & EPS effects (i.e. stiffness, gait disturbance). The pt might describe the medication as making them feel like a “robot”.

65
Q

2nd generation Atypical antipsychotics

A
  • targets both positive & negative symptoms of schizophrenia
  • block dopamine & serotonin
  • high incidence of significant weight gain, diabetes, & hyperlipidemia w/ use
  • low incidence of tardive dyskinesia
  • produces drowsiness (sedates w/o causing confusion; can use for severe anxiety instead of benzodiazapines)
  • may cause constipation

Ex. Latuda (Lurasidone); Zyperxa (Olanzapine)

66
Q

3rd generation Atypical antipsychotics

A
  • effective against both positive & negative symptoms of schizophrenia
  • block dopamine & serotonin
  • causes little / no weight gain
  • causes no increase in glucose, cholesterol, or triglycerides

Good choice for pts w/ obesity &/or heart disease

Ex. Abilify (Aripiprazole)

67
Q

Common Atypical (2nd & 3rd generation) Antipsychotics

A

Aripiprazole (Abilify)

Clozapine** (Clozaril)** - risk of Agranulocytosis

Lurasidone (Latuda)

Olanzapine (Zyprexa) - significant wt gain

Quentiapine (Seroquel)

Risperidone** (Risperdal)**

Ziprasi_done_ (Geodon) - prolonged QT interval

68
Q

Side effects of antipsychotics

A

Fewer overall SEs w/ Atypical antipsychotics

iSHADE

impotence

Sedation, seizures (reduce seizure threshold)

Hypotension, orthostatic

Akathisia (inability to sit still)

Dermatological effects (risk of severe sun burn)

Extrapyramidal rxns (acute dystonias, rigidity, tremor, tachycardia)

69
Q

Extrapyridamidal Side Effects (EPS)

A

movement disorders resulting from effects of antipsychotics on extrapyramidal motor system (primarily Typcial antipsychotics)

4 types of EPS reactions:

  • acute dystonia
  • pseudo-parkinsonism
  • akathisia*
  • tardive dyskinesia

*most common EPS

70
Q

Acute Dystonia

A

EPS rxn characterized by severe spasm of muscles of tongue, face, neck, or back

Torticollis (head turned & arched) & oculogyric crisis (upward deviation of eyes) occurs

rxn develops w/in 1st few wks of drug therapy; possibily w/in hrs of 1st dose

Requires rapid intervention if intense rxn

Anticholinergics used for initial trmt

71
Q

Psuedo-Parkinsonism

A

Mild EPS rxn characterized by bradykinesia, mask-like facies, drooling, tremor, rigidity, shuffling gait, cog wheeling, & stooped posture

Rxn develops w/in 1st month of drug therapy

Treat w/ central acting anticholinergics (i.e. benztropine (Cogentin), diphenhydramine)

Must AVOID use of Levadopa (promotes activation of dopamine; will induce psychosis)

72
Q

Akathisia

A

Serious & troublesome EPS rxn characterized by pacing & squirming (uncontrollable need to be in motion); profound sense of restlessness

Rxn develops w/in 1st 2 months of drug therapy

Most common reason for non-compliance w/ meds

Trmt is beta blockers & benzodiazapines (does not respond to anticholinergics)

Only “cure” is to stop taking antipsychotic

73
Q

Tardive Dyskinesia

A

Serious & troublesome EPS rxn characterized by abnormal muscle movements (i.e. slow, worm-like movements of the tongue, tongue flicking, lip smacking, pursing lips, grimacing)

Movements become constant; exhausting for the pt

Occurs late in antipsychotic drug therapy; 1 in 5 pts

Only trmt is to stop taking antipsychotic; maybe irreversible

Prevention is best approach; antipsychotics s/b used in lowest effective dose & for shortest time required; AIMS test every 3 mo. if long term use

74
Q

Acute Dystonic Reaction

A

Acute & dangerous EPS rxn

Acute dystonia that becomes life-threatening d/t involvement of the throat muscules

Inability to swallow & respiratory distress

Emergent use of anticholinergics necessary

75
Q

What medication is used to provide immediate relief to a pt. experiencing a dystonic reaction?

Dystonic reactions are emergencies & require intervention (can be caused by antipsychotics)

A

Diphendhydramine (Benadryl) IM or IV

or

Benztropine (Cogentin) IM or IV

IV response is 5 mins; IM response is 15 - 20 mins

Other anticholingerics may be used

76
Q

Neuroleptic Malignant Syndrome (NMS)

A

Acute & dangerous EPS rxn; life-threatening medical emergency; transfer to ICU

NMS symptoms: FEVER

  • Fever, sudden & high (1050+)
  • Encephalopathy
  • Vital signs unstable (dysrhythmias, BP fluctations)
  • Elevated enzymes (CK)
  • Rigidity of muscles

Death can result from respiratory failure, cardiovascular collapse, or dysrhythmias

Tmt is immediate w/drawal of antipsychotic, supportive measures & drug therapy

77
Q

The Bipolar Spectrum

A

Bipolar disorder mood cycling:

Mania

Hypomania

Normal mood

Mild depression

Major depression

78
Q

Manic episode

mnemonic

A

MANIC EPISODE

Mood swings

Active, agressive behavior

Nothing is wrong (denial)

Impulsive, intrusive behavior

Can’t sit still, can’t stop talk

Euphoric mood

Poor judgement, provocative behavior

Increased sexual interest

Substance (stimulant) abuse

Omnipotent feelings

Decreased need for sleep

Endless energy

79
Q

Rapid stabilization of the manic pt

A

Antipsychotics & benzodiazapines

Typical “cocktail” given in psych ER:

Haldol 5 - 10 mg w/ Avtivan 2 mg

80
Q

Bipolar disorder medications

A

Lithium (used for mood stabilization)

Anticonvulsants (used for mood stabilizaiton)

  • Depakote (valproate)
  • Tegretol (carbamazepine)
  • Lamictal (lamotrigine)

Antipsychotics (used for acute manic phase)

  • Seroquel (quetiapine)
  • Zyprexa (olanzapine)
  • Geodon (ziprasidone)
  • Ambilify (aripiprazole)
  • Risperdal (resperidone)
  • Haldol (haloperidol)
81
Q

Antidepressants and Mania

A

Use very cautiously w/ bipolar pts

All antidepressants induce mania in bipolar pts

If pt is bipolar, antidepressants should always be used in conjuction w/ a mood stabilizer.

82
Q

What are the 3 types of

bipolar disorder

A

Bipolar I

Bipolar II

Cyclothymic disorder

83
Q

Bipolar I disorder is def. as

A

mood disorder that is characterized by at least one-week long manic episode that results in excessive activity and energy

84
Q

The presence of three of the following behaviors constitues mania:

A

Extreme drive & energy

Inflated sence of self-importance

Drastically reduced sleep requirements

Excessive talking combined w/ pressured speech

Personal feeling of racing thoughts

Distraction by environmental events

Unusually obsessed with and overfocused on goals

Purposeless arousal and movement

Dangerous activities (ie. indiscriminate spending, reckless sexual encounters, or risky investments)

85
Q

Bipolar II disorder is def. as

A

low-level mania alternated with profound depression

this is called hypomania…unlike mania, psychosis is generally never present.

86
Q

Cyclothymic disorder is def. as

A

symptoms of hypomania alternate with symptoms of mild to moderate depression for at least two years in adults & one year in children.

87
Q

What are the 3 phases associated with bipolar disorders

A

Acute Phase

Continuation Phase

Maintenence Phase

88
Q

What is the primary outcome in the acute phase of bipolar disorders

A

The primary goal is

injury prevention

outcomes in the acute phase reflect both physiological and psychiatric issues

89
Q

the primary outcome in the continuation phase of bipolar disorders is:

A

can last for 4 - 9 months

overall outcome is relapse prevention, but consist of

Psycheducational classes for the pt. & family to:

a) understand the disease process

b) medication knowledge

c) knowledge of the early warning signs of replapse

90
Q

the primary outcome in the maintenence phase of bipolar disorder is:

A

continuing to focus of relapse prevention & limiting the severity and duration of future episodes.

91
Q

Personality disorders characteristic’s

defined

A

Pts with personailty disorders are inflexible & deomonstrate maladaptive responses to stress

  • they are unable to develop true intimacy with others
  • unable to develop trusting relationships.

“Impaired soical interaction”

92
Q

What are the 10 Personality disorders according to the American Psychiatric Association (APA)

A

1) Avoidant 2) Antisocial
3) Borderline 4) Dependent
5) Histrionic 6) Narsicistic
7) Paranoid 8) Obsessive-complusive
9) Shizioid 10) Schizotypical

93
Q

What are the Cluster “A” personality disorders?

Cluster “A” = odd or eccentric

A
  • Paranoid
  • Schizoid
  • Schizotypal
94
Q

What are the Cluster “B” personality disorders?

Cluster “B” = dramatic, emotional, erratic

A
  • Antisocial
  • Borderline
  • Histrionic
  • Narcissistic
95
Q

What are the Cluster “C” personality disorders?

Cluster “C” = anxious, fearful

A
  • Avoidant
  • Dependent
  • Obsessive-Compulsive
96
Q

Paranoid personality disorder

A

characterized by a longstanding distrust & suspiciousness of others based on the belief (unsupported by evidence) that others want to exploit, harm, or deceive them.

  • difficult to treat b/c they distrust everyone
  • have a need for space & reassurance
  • are hypervigilant

Projection is the dominant defense mechanism; they blame others for their shortcomings.

97
Q

Schizoid personality disorder

A

exhibits a poor ability to function in their lives…Relationships are particularly affected due to their prominent feature of emotional detachment.

need for soical isolation

Individuals do not seek out or enjoy close relationships. They are reclusive, avoidant, and uncooperative. They do not do well with resocialization.

98
Q

Schizotypal personality disorder

A

more common in men then women.

It is the 1st of the schizophrenia spectrum.

severe social and interpersonal deficits.

These individuals experience extreme anxiety in social settings & conversations tend to ramble w/ lengthy, unclear & overly detailed content.

eccentricity, odd or unusual beliefs (magical thinking)

prefer periods of solitude

99
Q

Histrionic personality disorder

A

characterized by emotinal attention-seeking behaviors & melodramatic, including self-centeredness, low frustration tolerance, & excessive emotionality

demonstrates poor verbal boundaries

  • In general, those with this disorder do not believe they need psychiatric help.
  • flirtatious - overly intense attachment w/ the opposite sex; provocative.
  • Psychotherapy is the txmt of choice.
100
Q

Narcissistic personality disorder

A

comes across as arrogant & w/ an inflated view of thier own self-importance (grandiose self-importance).

needs constant admiration

lack of empathy for others

pathological traits include: antagonism, represented by grandiosity and attention-seeking behaviors.

txmt includes cognitive-behavioral therapy, family & group therapy.

101
Q

Avoidant personality disorder

A

main traits are low self-esteem associated w/ feelings of inferiority compared to peers.

timid, socially uncomfortable

they tend to avoid engaging in new or unfamilar activities involving new people d/t fear of criticism or rejection

102
Q

Dependent personality disorder

A

people with this disorder have a high need to be taken care of, which can lead to patterns of submissiveness with fears of separation & abandonment by others.

urgently seek relationships

have a constant need for reassurance

lack self-confidence

Psychotherapy is the txmt of choice

103
Q

Obsessive-Complusive personality disorder

A

the most prevalent disorder in the general community - associated w/ the highest burden of medical cost.

main traits include: rigidity & inflexible standards of self & others — along with persistence of goals long after they are necessary.

They will typically rehearse over & over for situations where they will deal with others.

perfectionists (interferes w/ task completion)

SSRI’s & prozac may help.

104
Q

Anti-social personatily disorder

A

most studied & researched personality disorder

  • concerned with personal pleasure & power; does not conform to social norms

- characterized by decietfulness, impulsiveness, aggressiveness, disregard for others, lack of remorse, & manipulation.

usually presents w/ depression or because of the consequences of their behaviors, not because they care about the effects of their actions on others

Txmt w/one caregiver is preferred to avoid having the manipulative nature play one staff against another.

105
Q

Borderline personality disorder

A

has the central characteristic of instability in affect, identity, & relationships

desperately seek relationships to avoid feeling abandoned, but often drive others away with excessive demands, impulsive behavior, or uncontrolled anger.

chronic feelings of emptiness

assess for suicidal & self-mutilating behaviors, especially during times of stress…Risk for self-directed violence.

teach pt to identify triggers & positive coping

The frequent use of the defense of splitting strains personal relationships & creates turmoil in health care settings.

106
Q

What is Splitting

A

involves loving a person, then hating the person b/c the pt. is unable to recognize that an individual can have both positive and negative qualities.

black & white thinking

defense mechanism often used with BPD

107
Q

Which medication is the drug of choice for safe alcohol w/drawals

A

Benxodiazepines

108
Q

Which medicaton is used in the treatment of both alcohol and opiod addiction

A

Naltrexone (ReVia) - it is an opiod antagonist that blocks the action of opiods & reduces alcohol cravings.

109
Q

Types of Antidepressants

A
  • SSRIs
  • SNRIs
  • TCAs
  • MAIOs
110
Q

SSRI info

A

First-line approach for trmt of depression

Increases Serotonin levels in brain

Uses: Major Depressive Disorder, anxiety disorders, panic disorders & OCD

Mood responds gradually (over 2 wks)

Do NOT STOP taking ABRUPTLY

111
Q

Common SSRIs

A

Citalopram (Celexa)

Escitalopram (Lexapro)

Fluoxetine (Prozac)

Paroxetine (Paxil)

Sertraline (Zoloft)

112
Q

SSRI side effects mnemonic

A

BAD SSRI

Body wieght increase Seritonin Syndrome

Anxiety Stimulation of the CNS

Dizziness Reproductive dysfuntion

Insomnia

113
Q

Serotonin Syndrome

A

Toxicity resulting from SSRI use w/ other meds that increases serotonin

Manifestions: HARM

Hyperthermia

Autonomic instability (delirium)

Rigidity

Myoclonus

  • Be alert for sweating & diarrhea
  • Late sign is apnea & death
114
Q

Serotonin Syndrome interventions

A

Stop SSRI

Administer serotonin-receptor blocker

Cooling blankets or meds to reduce fever

Benzodiazepines for seizures & muscle rigidity

Anticonvulsants for seizures

Ventillation support for apnea

115
Q

SNRI info

A

Increases Serotonin & Norepinephrine levels in brain

Treats both chronic neuropathic pain & depression

116
Q

Common SNRIs

A

Duloxetine (Cymbalta)

Venlafaxine (Effexor)

117
Q

SNRI side effects mnemonic

A

BAD SNRI

Body wieght increase Suicidal thoughts

Anxiety Nausea / vomiting

Dizziness Reproductive dysfuntion

Insomnia

118
Q

TCA info

A

Boosts Norepinephrine

Uses: adjunctive therapy to treat chronic neuropathic pain & anxiety disorders; used only when other antidepressants fail or need to be boosted

SEs much more bothersome than SSRI class; results in nonadherence

Effects are slow to work

Do NOT stop taking abruptly

119
Q

Common TCAs

A

Amitriptyline (Elavil)

Clomipramine (Anafranil) - risk for glacoma

Imipramine (Tofranil)

120
Q

Tricyclic antidepressant (TCA)

side effects mnemonic

A

TCAS

Thrombocytopenia (low platelets)

Cardiac (arrythmia, MI, stroke)

Anticholinergic effects (tachycardia, urinary retention dry mouth, etc)

Seizures

121
Q

TCA overdose

A

TCA toxicity / overdose can be fatal

Signs associated w/ toxicity:

  • altered LOC / delirium
  • arrhythmias: VTach, VFib, prolonged QRS, QT & PR intervals
  • vomiting
  • fever
  • coma
  • hypoventilation from CNS depression
122
Q

MAOI info

A

Rarely used d/t danger they present when combined w/ certain pharmaceuticals & foods

Uses: _Atypical depressio_n (oversleeping & overeating); adjunctive med for anxiety disorders & bulemia

Monitor BP

AVOID tyramine, alcohol, & yeast

Do NOT take w/ oral decongestant

Dietary & med restrictions to stay in place 2 wks after MAIO stopped

123
Q

Common MAOIs

A

Phenelizine (Nardil)

Isocaroxzid (Marplan)

Tranylcyproine (Parnate)

124
Q

MAOI side effects mnemonic

A

HAHA

Hypotension, orthostatic

Anticholinergic effects

Hypertensive crisis (avoid tyramine foods)

Anxiety, agitation, anorexia

125
Q

MAOI toxicity

A

Toxicity can occur when MAOIs are combined w/ certain foods & medications resulting in Hypertensive Crisis & death

MAOIs prevent the break down of tyramine & certain meds; results in significant vasoconstriction

126
Q

Tyramine containing foods

A

Aged & fermented foods:

  • All hard cheese (use caution w/ Italian & Mexican foods)
  • pickled or smoked meats
  • olives, pickles, sauerkraut
  • soy sauce (avoid Asian foods)
  • ripe alvocados
127
Q

Bupropion (Wellbutrin)

A

“Other” antidepressant

Boosts Norepinephrine & Dopamine

Only antipressant w/out unpleasant sexual SEs

Lowers seizure threshold

Not very effective w/ anxiety or pain

Effective in treating nicotine addiction & ADHD

128
Q

Anxiolytic info

A

2 types: Benzodiazipines & Non-benzodiazipines

Benzodiazepines:

  • target GABA
  • uses: sedative effect for anxiety; anticonvulsant effect for seizures (Klonopin); prevention of seizures induced by alcohol w/drawal (Librium)
  • lead to physical & psychological dependence
  • short term use only (1-2 wks)
  • do NOT discontinue abruptly
  • when combined w/ alcohol can result in overdose & death by respiratory suppression
129
Q

Common Anxiolytics

A

Benzodiazapines:

  • Aloprazolam (Xanax)
  • Lorazepam (Ativan)
  • Chlordiazepoxide (Librium) - use for severe DTs
  • Diazepam (Valium)
  • Clonazepam (Klonopin) - effective anticonvulsant

Non-benzodiazapines:

  • Buspirone (BuSpar)
130
Q

Buspirone (BuSpar)

A

Does not result in tolerace or addicition

Targets Serotonin & Dopamine

Does not have rapid onset of action

Takes up to 2 wks to be effective

Must be taken daily; not for PRN use

AVOID drinking grapefruit juice

131
Q

Antimania meds (mood stabilizers)

A

Lithium

Anticonvulsants: treat/prevent mood episodes in Bipolar by slowing neuron firing & mood cycling

  • Valproate / Valproic acid (Depakote)
  • Carbamazepine (Tegretol)
  • Lamotrigine (Lamictal) - risk of SJS (severe rash)
  • Clonazepam (Klonopin) - anxiolytic/benzodiazepine effective for seizures

Depakote & Tegretol require blood levels to be monitored for therapeutic effect; periodic monitoring of liver enzymes & CBC

132
Q

Lithium info

A
  • Lithium is a salt; regulated by body like sodium
  • Be very alert for SUDDEN DROPS in sodium
  • Lowering of dietary sodium intake, use of diuretics, excessive sweating or vomiting can have drastic effect on lithium; if Sodium goes DOWN, Lithium goes UP
  • Narrow therapeutic index (0.6 - 1.2)
  • 3 wks to reach therapeutic level; not for quick control of mania
  • Teach strict adherence to dosing regimen
  • Fluid intake 1-2qt/day & maintain normal salt intake
133
Q

Acute Lithium Toxicity symptoms

mnemonic

A

CAN HAM SUCS

Confusion

An increase of urine & thirst

Nausea

Hand tremors (coarse)

Ataxia (uncoordinated arm & leg movements)

Muscle twitches

Seizures

Uncontrollable eye movements

Coma

Slurred speech

134
Q

Medications for treatment of Alcohol Abuse

A

Naltrexone hydrochloride (ReVia, Vivitrol)

Disulfiram (Antabuse)

  • causes unpleasant effects when alcohol is consumed; negative reinforcer
  • AVOID foods/products containing alcohol (cough syrup, mouthwash, cooking wine)
  • extremely poor compliance; does not reduce alcohol cravings

Acamprosate (Campral)

  • eliminated thru kidneys; pts w/ kidney disease at risk for adverse rxns
  • eases discomfort of w/drawal & prevents cravings
  • stimulates GABA