Menstruation Flashcards
What is dysmenorrhoea?
Excessive pain during menstrual period
How does dysmenorrhoea commonly present?
Lower abdominal or pelvic pain
Radiate to pelvis and thighs
+ malaise, nausea, vomiting, dizziness, diarrhoea
What investigations would you request for dysmenorrhoea?
High vaginal and endocervical swabs - infection?
Transvaginal USS - if masses on examination
Speculum exam
Cervical smear - if nearly due
Pelvic USS
Compare the pain in primary vs secondary dysmenorrhoea
primary: Pain at onset of menses. Often within first 2 years of menarche
secondary: Pain precede start of menses by days. Occur years after menarche
What can cause secondary dysmenorrhoea?
How is it managed in primary care?
Endometriosis Adenomyosis PID Adhesions Fibroids Non-gynae such as IBD and IBS
Refer all to gynae for investigation
What is primary dysmenorrhoea?
Pain in absence of any underlying pelvic disorder -
Diagnosis of exclusion
What causes primary dysmenorrhoea?
Excess release of prostaglandins from endometrial cells:
- Spiral artery vasospasm
- Increase myocetrial contractions
What are the risk factors for primary dysmenorrhoea?
Early menarche
Heavy periods
Smoking
Nullparity
How is primary dysmenorrhoea managed?
Stop smoking, TENS, heat
- NSAIDs (inhibit prostaglandin production)
- mefenamic acid and naproxen - Hormones: Monophasic use of COCP, IUS
How is primary amenorrhoea defined?
Menses not occurred by:
14 - absence of any secondary sexual characteristics
16 - other secondary sexual characteristics developing normally
How is secondary amenorrhoea defined?
Menstruation occurred before but has stopped for 6 successive months
What is oligomenorrhoea?
Irregular periods with intervals between cycles of >35 days or <9 periods in a year
What is a good way of categorising differentials of amenorrhoea?
Hypothalamic - low GnRH Pituitary Ovarian Genital tract Other
What are some causes for reduced GnRH i.e. hypothalamic amenorrhoea?
Secondary:
- Eating disorders
- Severe chronic conditions - thyroid
Primary:
- Kallmann syndrome (poor smell and hearing)
What pituitary issues can lead to amenorrhoea?
All secondary:
- Prolactinomas - prolactin suppress GnRH
- Other pituitary tumours - mass effect
- Sheehan’s syndrome - blood loss in childbirth
- Prolonged contraceptive use - down regulate pituitary
What ovarian issues can cause amenorrhoea?
Secondary:
- PCOS
- Premature ovarian failure
Primary:
- Turner’s syndrome
How is premature ovarian failure characterised?
Amenorrhoea + raised gonadotrophins (FSH and LH) before 40
What conditions affecting the genital tract can cause amenorrhoea?
Secondary: Ashermann’s syndrome - intrauterine adhesions following uterine surgery
Primary: Mechanical obstruction - imperforate hymen
What are the other causes of amenorrhoea?
Secondary:
- Pregnancy
Primary:
- Congenital adrenal hyperplasia
- Constitutional delay
What are the primary causes of amenorrhoea?
Congenital adrenal hyperplasia Constitutional delay Mechanical obstruction Turners syndrome Kallmann syndrome
What questions do you need to ask in a history about amenorrhoea?
Full menstrual history Poss. of pregnancy Galactorrhoea Vasomotor symptoms Acne, hirsutism, balding Exercise and eating habits
What investigations would you request for a women with amenorrhoea?
FSH and LH Total Testosterone BMI Pregnancy test Prolactin Thyroid function Pelvic USS Sex hormone binding globulin
What would a raised FSH and LH in the context of amenorrhoea indicate?
Ovarian failure
Turner’s
What would a normal to low FSH and LH in the context of amenorrhoea indicate?
Constitutional delay
Hypothalamic cause
What may a raised total testosterone in amenorrhoea indicate?
Congenital adrenal hyperplasia
PCOS
What would an a)low and b)raised sex hormone binding globulin in amenorrhoea indicate?
Low - contraceptive pill
Raised - obesity
How can amenorrhoea be managed?
COCP or POP - regulate periods
Hormone replacement with vitamin D and calcium if ovarian failure
Weight management
Metformin - PCOS
Define menorrhagia
Excessive menstrual loss that interferes with the women’s daily living
What is the average blood loss in a menstrual cycle?
30-40ml
What can cause menorrhagia?
Anovulatory cycles
Structural issues - fibroid, polyp, adenomyosis
Systemic conditions - hypothyroidism, clotting disorder
Copper coil
PID
Malignancy
How would you assess a woman with menorrhagia?
FBC - anaemia
TV USS - palpable mass, dysmenorrhoea, intermenstrual bleeding, treatment failure
+/- Abdominal exam - masses
+/- Pelvic exam
+/- Speculum exam
What is dysfunctional uterine bleeding?
Menorrhagia which can’t be attributed to specific cause
50% of cases
How is menorrhagia managed?
Do not need contraception?
Mefenamic acid or TXA
Need contraception?
- Mirena IUS
- COCP
- long acting progesterone e.g. depo-provera
What are the surgical management options for menorrhagia?
Endometrial ablation
Hysterectomy
What is menopause?
Permanent cessation of menstruation
What is the average age of menopause?
51 yo
When is menopause diagnosed?
12 months of amenorrhoea
How long do menopausal symptoms normally last?
7 years
What is climacteric/perimenopause?
Period prior to menopause where women experience symptoms such as ovarian function start to fail
From age 45
What hormonal changes occur in menopause?
!!Reduction in follicle!! number - also less inhibin
Decrease in available binding sites
!!Reduced sensitivity!! of ovary to circulating LH and FSH
!!Reduced oestrogen secretion!!
Negative feedback reduced
Circulating LH and !!FSH increase!!
How is menopause diagnosed?
Clinical diagnosis - hormone levels not normally necessary
Raised FSH not diagnostic but indicate reduced ovarian response
Investigate differentials
How long do women need to use contraception around menopause?
<50 yeas old = 2 years after last period
>50 years old = 1 year after last period
What are some psychological symptoms associated with menopause?
Dizzy Interrupted sleep Anxiety Poor memory/concentration Depressive mood Irritable Reduced libido
What happens to menstruation in menopause?
Abnormal cycle length - could be shorter or longer
Oestrogen breakthrough bleeding
What changes are seen in the vagina in menopause?
Dryness
Painful intercourse
What urinary symptoms may be present in menopause?
Incontinence
Urgency
Atrophy - share embryological origin with vagina so affected by low oestrogen
What musculoskeletal problems may women suffer from in menopause?
Joint soreness
Joint stiffness
Back pain
What skin changes are seen in menopause?
Hot flush - spread from face down to neck and chest Dry Itching Thinning Tingling
How do breasts change in menopause?
Enlargement
Pain
What are some systemic symptoms of menopause?
Weight gain
Night sweats
Why can you get breakthrough bleeding in menopause?
Progesterone req. to support endometrium
If no ovulation then endometrial lining break down
What diseases are associated with menopause?
Vascular - ischaemic heart disease, stroke, peripheral artery disease
Osteoporosis
Alzheimers
Why is menopause associated with IHD, stroke and peripheral artery disease?
Oestrogen lower LDL and raise HDL
Redistribution of body fat to abdomen
How is menopause managed?
Lifestyle modification
HRT
What lifestyle changes can be made to help reduce menopause symptoms?
Stop smoking
Reduce alcohol and caffeine intake
Regular exercise and weight loss
Calcium supplements
How are vasomotor symptoms of menopause managed?
fluoxetine
or citalopram or clonidine
How are psychological symptoms of menopause managed?
HRT and CBT
How is a low sexual desire in menopause managed?
HRT
Testosterone supplementation
How is vaginal dryness in menopause managed?
Lubrication
Estriol (vaginal oestrogen)
Who is HRT used in?
Menopausal women where benefits will outweigh risks
What are the types of HRT?
Oestrogen and progesterone or oestrogen alone
Cyclical (progesterone for last 14 days) or continuous
Oral or transdermal
What must women with a uterus who request only oestrogen replacement therapy also have?
Mirena coil to provide progesterone
What are the side effects of HRT?
Erratic bleeding for first 3 months
Progesterone - fluid retention, weight gain, mood swings, pelvic pain
Oestrogen - breast tenderness, leg cramps, bloating
What are the risks of HRT?
VTE - much higher risk if combined and oral. Reduced risk with transdermal patch
Breast cancer - much higher risk if combined and continual not cyclical
Stroke
Endometrial cancer - oestrogen only
Ovarian cancer
IHD
How is HRT stopped?
Gradually reduced or stopped immediately
If stopped immediately, may get short term symptom recurrence
What are the cautions and contraindications for HRT?
Breast cancer
Oestrogen sensitive cancers
Undiagnosed vaginal bleeding
Untreated endometrial hyperplasia
What are the benefits of HRT?
Improved symptoms - esp. vasomotor, mood and urogenital
Reduced risk of CVD and osteoporosis
Reduced risk of colorectal cancer
In perimenopausal women would you use cyclical or continuous HRT preparations? Why?
Use cyclical as they get a predictable withdrawal bleed whereas in continuous they get unpredictable bleeds