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Pharmacology > Menstrual Related Disorders > Flashcards

Menstrual Related Disorders Flashcards

1
Q

MC of amenorrhea?

A

Unrecognized pregnancy is the most common cause of amenorrhea

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2
Q

What are the variety of disorders that fall under Polycystic ovary syndrome (PCOS)

A

amenorrhea
menorrhagia
anovulatory bleeding

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3
Q

First line therapy for secondary amenorrhea?

A

Micronized progesterone

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4
Q

What is the 1st line for Dysmenorrhea (painful menstruation)

A

NSAIDS

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5
Q

If NSAIDS are not effective what other agents can be used next?

A

Depo MPA or LNG-IUS (intra-uterine device)

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6
Q

How long do you need to assess if NSAIDs are helping with dysmenorrhea?

A

2-3 menstrual cycles

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7
Q

What is menorrhagia?

How is it determined?

A

Excessive or heavy bleeding

The amount of tampons/pads changed hourly/daily

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8
Q

What is Tranexamic acid used to treat?

A

Menorrhagia

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9
Q

MOA of Tranexamic acid?

A

Antifibrinolytic effects by reversibly blocking lysine binding sites on plasminogen, preventing fibrin degradation and a reduction in menstrual blood loss

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10
Q

How long until you see a reduction of blood loss while using Tranexamic acid?

A

first 3 months of therapy

Should see an improvement in hemaglobin and hematocrit

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11
Q

What are first line treatments for Amenorrhea caused by hyperprolactinemia?

A

Dopamine Agonists

Bromocriptine and Cabergoline

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12
Q

ADE of Bromocriptine/Cabergoline?

A 
Hypotension,
 nausea, 
constipation, 
anorexia, 
Raynaud’s phenomenon,
 fatigue, 
headache
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13
Q

What are ADE in using Combination OC for amenorrhea?

A 
Thromboembolism, 
breast enlargement, 
breast tenderness, 
bloating, 
nausea, 
GI upset,
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14
Q

What is the MOA of CEE (Conjugate Estrogen)?

A

Estrogen replacement for hypoestrogenic states leading to anovulatory bleeding

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15
Q

What are the MOA of taking MPA for amenorrhea?

A

Suppresses FSH and LH and ultimately estrogen and progesterone, inhibiting the usual growth of the endometrium

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16
Q

What are ADE when taking MPA for amenorrhea

A 
Edema, 
anorexia, depression, 
insomnia, 
weight gain or loss,
increase in serum total and LDL cholesterol, 
may reduce HDL cholesterol
17
Q

What are ADE of taking Tranexamic acid

A

Nausea, diarrhea, dyspepsia

18
Q

First line agent used for Premenstrual Dysmorphic Disorder

A

SSRI-Citalopram

19
Q

What are ADE of using SSRI to treat Premenstrual Dysmorphic Disorder

A

Sexual dysfunction
Insomnia
Sedation
Hyperinsomnia

Pharmacology (12 decks)

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