Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Headache management > Flashcards

Headache management Flashcards

1
Q

What is a Medication-overuse Headache/Rebound Headache

How does this happen?

A

The frequent or excessive use of acute migraine medications

headache returns as the medication wears off, leading to the consumption of more drug for relief.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How can you prevent rebound headaches?

A

Limit the use of acute migraine therapies to fewer than 10 days per month

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are symptoms associated with Migraine headaches

A

Frequently unilateral

untreated can last from 4 to 72 hours

nausea, vomiting
sensitivity to light, sound, and/or movement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is an important part of the pathophysiology that cause migraines?

A

Activation of trigeminal sensory nerves triggers the release of vasoactive neuropeptides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What drugs fall under Analgesic class

A

Acetaminophen (Tylenol)

Acetaminophen 250 mg/aspirin 250 mg/caffeine 65 mg (Excedrin Migraine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What drugs fall under NSAIDS

A

Aspirin
Ibuprofen (Motrin)
Naproxen sodium (Aleve, Anaprox)
Diclofenac (Cataflam, Voltaren)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What drugs fall under Serotonin Agonists (Triptans)

A

Sumatriptan

Zolmitriptan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What do Non-selective 5-HT1 receptor agonists do?

A

Constrict intracranial blood vessels and inhibit the development of neurogenic inflammation in the trigeminovascular system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MOA of Triptans?

A

Selective agonists of the 5-HT1B and 5-HT1D receptors

Result of three key actions:

  • normalization of dilated intracranial arteries through enhanced vasoconstriction
  • inhibition of vasoactive peptide release from perivascular trigeminal neurons
  • inhibition of transmission through second-order neurons ascending to the thalamus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the maximum dosage of oral Sumatriptan?

A

200 mg max dosage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What should you avoid with oral and nasal Zolmitriptan?

A

Do not divide the two forms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

When taking Ergotamine what should you take with it?

A

consider pretreatment with an antiemetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are Metoclopramide useful for Prochlorperazine

A

Useful for adjunct therapy relief in the office or emergency department setting

Also is an anti-emetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is an Adverse event when taking Triptan

A

“Triptan sensations”

Chest tightness,
pressure,
heaviness, or
pain in the chest, neck, or throat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What can Sumatriptan be used for to treat?

A

Migraine AND cluster headache

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

ADE of Sumatriptan?

A

Paresthesias, dizziness, chest pain

• possible coronary vasospasm

17
Q

How do you treat Serotonin syndrome caused by Triptan drugs?

A

Sedation (benzodiazepines)
Paralysis
Intubation and ventilation

18
Q

How do you treat Neuroleptic malignant syndrome

A

Diphenhydramine (parenteral),

cooling if temperature is very high

19
Q

How do you treat Malignant hyperthermia

A

Dantrolene, cooling

20
Q

What medications can be used as preventative therapy for migraines

A

Propranolol
Timolol
Divalproex sodium
Topiramate

21
Q

What migraine med can be used intermittently, such as for menstrual migraine prevention

A

Ibuprofen

22
Q

What migraine med can be taken in the perimenstrual period to prevent menstrual migraine

A

Frovatriptan

23
Q

MC type of headache?

A

Tension type headache- pain is like a band squeezing the head

24
Q

1st line treatment for Tension Headaches?

What is another alternative

A

Simple analgesics - Acetaminophen

NSAIDS

25
Q

When treating Tension headaches, butalbital-containing meds should be taken no more than how many times per month

A

3 days

26
Q

When treating Tension headaches, combination analgesics meds should be taken no more than how many times per month

A

9 days

27
Q

When treating Tension headaches, NSAIDS should be taken no more than how many times per month

A

15 days

28
Q

What meds can be used for preventative therapy for Tension type headaches

A

TCAs (tricyclic antidepressants)

SSRIs (Selective Serotonin Reuptake Inhibitors) –> only effective in patients who also have depression

29
Q

What is not recommended for preventative therapy for Tension HA?

A

Botulinium toxin

30
Q

What are cluster headaches and how are they described?

A

Headache around the eye

Excruciating, unilateral head pain that occur in series lasting for weeks or months

31
Q

What is a hallmark finding of Cluster HA?

A

circadian rhythm of painful attacks.

32
Q

What is the standard of treatment for Cluster HA?

A

Abortive Therapy

Inhalation of 100% oxygen by nonbreather facial mask

Triptans sprays or injections

Ergotamine Derivatives –> Clinically IV dihydroergotamine , or ergotamine tartrate

33
Q

What is 1st line PROPHYLACTIC treatment of Cluster HA

A

Verapamil

Pharmacology (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions