Labor and Delivery

Question 1

What electrolyte helps control uterine contractions?

Answer 1

Calcium

Question 2

What channel has an inhibitory effect in controlling uterine contractions

Answer 2

KATP - ATP sensitive potassium channel

Question 3

What affect does Oxytocin produce?

Answer 3

Uterine contraction and Cervical ripening

Controls post partum depression

Question 4

Whats an example of a oxytocin drug?

Answer 4

Pitocin

Question 5

What is the MOA of Prostaglandin E2 (PGE2)

Answer 5

Promotes contractions and cervical ripening

Question 6

What drug is Prostglandin E2?

Answer 6

Dinoprostone

Question 7

What are the 2 forms of Dinoprostone (PGE2)

Answer 7

Gel and vaginal insert

Question 8

What analogue does Carbapost promote?

Answer 8

Prostaglandin F2-alpha (F2a)

Question 9

What is the MOA of Carbapost?

Answer 9

Causes strong uterine contractions

Question 10

What situation is Carbapost most commonly used during

Answer 10

Postpartum hemorrhage

Question 11

What stage in pregnancy is Carbapost used in and why?

Answer 11

13-20 weeks

Used by some to induce uterine emptying

Question 12

Side effects of Carbapost?

Answer 12

Bronchospasma - contrainidicates in asthma
Hypertension
Choking

Question 13

What is the use of Mifeprestone

Answer 13

Prostaglandin antagonist used to terminate pregnancy up to 49 days

Question 14

MOA of Mifeprestone

Answer 14

Uterine contractions up to day 49

Question 15

What 3 drugs can be given to control postpartum hemorrhage?

Answer 15

Oxytocin

Carbopost

Methylergonovine

Question 16

What is the MOA of Methlergonovine?

Answer 16

Uterine contraction and vasoconstriction

Question 17

Name of an agent that ceases uterine contractions?

Answer 17

Tocolytic agents

Question 18

When is a Tocolytic agent most commonly used for?

Answer 18

To suppress labor that would result in delivery of a premature infant

Question 19

Tocolytic agents allow the maturity of what system in an fetus?

Answer 19

Lung maturity - with the use or corticosteroids

Question 20

What are 4 drugs that suppress uterine contractions?

Answer 20

Terbutaline
Nifedipine
NSAIDs (indomethacin, ibuprofen)
Magnesium

Question 21

What drug class does Terbutaline fall under?

Answer 21

B2 agonist

Question 22

MOA of Terbutaline?

Answer 22

B2 agonist that causes uterine smooth muscle relaxation

Question 23

Side effects when using Terbutaline as a B2 agonist?

Answer 23

Tachycardia
pulmonary edema
hypokalemia 
metabolic acidosis
Hypotension

Question 24

What Black box warning is including when taking Terbutaline?

Answer 24

Avoid taking for a prolonged period of time, can cause maternal cardiotoxicity and death

Question 25

How many days can Magnesium be used for without experiencing ADE?

Answer 25

5-7 days

Question 26

What FDA warning is associated with prolonged use of Mg for uterine contraction suppression?

Answer 26

Can cause hypocalcemia –> osteopenia or bone fractures

Question 27

What category drugs is Mg?

Answer 27

category D

Question 28

What are side effects of taking Mg?

Answer 28

Weakness
paralysis
Respiratory failure
Hypotension

Question 29

What type of drug is Nifedipine? MOA

Answer 29

Calcium channel blocker

Relaxes uterus smooth muscle

Question 30

What two NSAIDs are used to prevent uterine contractions?

Answer 30

Indomethacin

Ibuprofen

Question 31

What is the MOA of NSAIDs for uterus contraction suppression?

Answer 31

Prevent the formation of prostaglandins

Question 32

What side effects do NSAIDS cause?

Answer 32

Decrease GFR

Narrow closure of fetal ductus arteriosis

Question 33

What drug is given to pregnant women with a history of miscarriages?

Answer 33

Hydroxyprogesterone caproate?