Menstrual disorders Flashcards

1
Q

Look

A

The menstrual cycle is the time from the first day of a woman’s period to the day before her next period

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2
Q

What is considered ‘normal’ blood loss during a period?

A

less than 80ml over 7 days (16tsp) but on average it is 30-40ml

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3
Q

Average duration of a period?

A

2-7 days

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4
Q

What is Menarche?

A

The onset of a female’s period

On average they start between 10-16 years

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5
Q

Common disturbances of menstruation

A
  • Disturbance of menstrual frequency – infrequent or frequent
  • Irregular menstrual bleeding – absent or irregular
  • Abnormal duration of flow – prolonged or shortened
  • Abnormal menstrual volume – heavy or light.
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6
Q

What is classed as an infrequent period?

A

>38 day cycle

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7
Q

What things can you find out about a woman’s periods that indicate heavy menstrual bleeding?

A
  • Do they need to change their menstrual product every 1-2 hours?
  • Do they pass blood clots greater than 2.5 cm
  • Do they bleed through their clothes?
  • Do their periods affect their QOL?
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8
Q

Give an example of a health implication associated with heavy menstrual bleeding?

A

Anaemia

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9
Q

What are some common causes of heavy menstrual bleeding?

A
  • Ovulatory dysfunction - anovulation means a lack of progesterone production leading to hormone imbalance which can cause menorrhagia
  • Bleeding disorders i.e von Willebrand disease (VWD) or platelet function disorder
  • Adenomyosis
  • Pelvic inflammatory disease e.g chlamydia
  • Cervical cancer
  • Endometrial cancer
  • Uterine polyps
  • Uterine fibroids
  • Copper IUD
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10
Q

What is the pneumonic used to remember the causes of HMB?

A

PALM COIE

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11
Q
  1. What are fibroids? (‘myoma’/’ileomyoma’)
  2. What symptoms can they cause?
A
  1. Non-cancerous growths made of muscle and fibrous tissue
  2. They can be asymptomatic or they can cause things like
    • HMB
    • Pelvic pain
    • Urinary symptoms
    • Pressure symptoms
    • Infertility
    • Backache
    • Miscarriage
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12
Q

How are fibroids diagnosed and managed?

A

Diagnosis by USS

Management is symptom based.

  • If HMB and small fibroids then the combined pill, mini pill or hormone IUD may be enough to control symptoms
  • If fibroids are large and fertility preservation is desired then fibroid embolisation (block off arteries) or myomectomy
  • If submucosal fibroids then hysteroscopic fibroid resection
  • If declined or failed medical treatment and the woman doesn’t want to remain fertile then hysterectomy
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13
Q

What is Endometriosis?

A
  • Where there is endometrial tissue present outside the lining of uterus.
  • During menstruation this ectopic tissue behaves the same as the endometrium and bleeds. However, in this case the blood has no way to escape. This can cause inflammation, pain and the formation of scar tissue.
  • It is a chronic and debilitating condition that causes painful periods. It is complex and often has multi-system involvement
  • Can severely affect QOL of women - potential to cause infertility, fatigue etc
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14
Q

How might Endometriosis present?

A
  • Most often pelvic pain and dysmenorrhoea (cramps/pain)
  • May present with HMB
  • The severity of symptoms may not correspond with the size of deposit - someone with less peritoneal scarring and smaller deposits may have severe pain and vice versa
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15
Q

Symptoms of Endometriosis

A
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16
Q

Is Endometriosis easy to diagnose?

A

No, it can be quite complex and often women are left without a diagnosis for years. This adds to the psychological impacts.

Symptoms can be vague. Healthcare professionals will often misdiagnose it as:

  • IBS
  • Depression
  • Period pain
  • PCOS
  • Fatigue
  • Overactive imagination
17
Q

How is Endometriosis categorised into stages?

A

By its severity and the size of the deposits

18
Q

What are the stages of Endometriosis?

A

Stage 1 - minimal - small patches, surface lesions or inflammation on or around organs in the pelvic cavity

Stage 2 - mild - more widespread and starting to infiltrate pelvic organs

Stage 3 - moderate - periotenum or other structures are involved. Sometimes there is also scarring and adhesions

Stage 4 - severe - infiltrating many pelvic organs and ovaries, often with distortion of the anatomy and adhesions

19
Q

Diagnosis and management of Endometriosis

A

Diagnosis

  • History - listen to the woman
  • Pelvic examination - areas of tenderness? abnormal anatomy?
  • Diagnostic laparoscopy = gold standard - can be negative 50% of time
  • USS - not sensitive for small endometriotic deposits/scars

Management

  • Analgesia
  • Medical treatment - combined pill, mini pill, IUD (hormone), Depot provera (injection) or GnRH Analogues
  • Surgical - Ablation, Hysterectomy, endometrioma excision, pelvic clearance,
20
Q

Adenomyosis

  1. What is it?
  2. What symptoms does it cause?
  3. How is it treated?
A
  1. A condition where the endometrium becomes embedded in the myometrium
  2. This results in HMB and patient can have significant dysmenorrhoea
  3. May respond to hormones partially but definitive treatment is hysterectomy
21
Q

Endometrial polyps

  1. What are they?
  2. How are they diagnosed?
  3. How are they managed?
A
  1. ´Overgrowth of the endometrial lining can lead to formation of pediculated structures called polyps which extend into the endometrium. They are mostly benign.
  2. Diagnosis is by USS or hysteroscopy
  3. Management = polypectomy
22
Q

How is HMB managed?

A
  • A thorough history
  • Pelvic examination - speculum and bimanual examination
  • Clotting profile, thyroid function
  • Pelvic USS - fibroids or polyps?
  • Laparoscopy - if endometriosis is suspected
23
Q

When should an endometrial biopsy be obtained?

A

From all women aged 44 or above with heavy menstrual bleeding - to look for endometrial hyperplasia or carcinoma

24
Q

Look

A

Remember women have many options and they should be presented with all the information in order to make an informed decision on their treatment.

25
Q

What are the hormonal treatment options for Endometriosis?

A

Minera IUS

Combined pill

Mini pill - POP

Depot provera - injection

26
Q

What are the non-hormonal treatment options for Endometriosis?

A

Medical

  • Mefenamic acid - reduces blood loss by 30% and pain
  • Tranexemic acid - antifibrinolytic - reduces blood loss by 60%
  • GnRh Analogues - stop oestrogen production which deprives the endometriomas of it and puts the body in temporary menopause

Surgical

  • Endometrial ablation - permanent destruction of endometrium using different energy sources
  • Fibroid embolistaion
  • Hysterectomy - surgical removal of the uterus
27
Q

Total vs subtotal hysterectomy

A
  • Total hysterectomy: cervix and uterus removed
  • Subtotal hysterectomy: uterus removed, cervix left
28
Q

What is Salpingo-oophorectomy?

A

Removal of the tubes and ovaries

Usually done if woman has endometriosis or presence of ovarian pathology

  • Disadavantage = the immediate onset of menopause which can reduce the QOL of a younger woman.
  • Advantage = reduces risk of subsequent ovarian cancer
29
Q

Why might a woman/girl not get her period?

A
  • Life changes: stress, eating disorders/malnourishment, obesity, Intense exercise
  • Hormones: POP, Mirena, depot injection
  • Primary ovarian insufficiency
  • PCOS
  • Hyperprolactinemia (elevated levels of prolactin in the blood)
  • Prolactinomas (adenomas on the anterior pituitary gland)
  • Thyroid disorders - hyperthyroidism i.e Graves’s disease
  • Obstructions of the uterus, cervix, and/or vagina

´Investigate and treat the cause

30
Q

PCOS

A

PCOS is common. It is a metabolic syndrome.

To be diagnosed with PCOS women must meet 2 of 3 of the Rotterdam criteria:

  • USS appearance of ovary - cystic ovaries
  • Hyperandrogenism (high levels of testosterone) - clinically and biochemically - clinical hyperandrogenism signs e.g hirsuitism, acne, infertility and obesity
  • Oligoovulation or anovulation - irregular or absent periods

Management = lifestyle adjustment with aim to achieve normal BMI

Symptom based treatment

31
Q

Symptoms of PCOS

A
  • Irregular menstrual cycle
  • Too much hair/Hair thinning
  • Acne
  • Weight gain
  • Darkening of skin
  • Skin tags
32
Q

What is Dysfunctional Uterine Bleeding?

A
  • Any bleeding from the vagina that varies from a woman’s normal menstrual cycle.
  • This bleeding is not due to pregnancy or any recognisable uterine or systemic diseases
  • The main cause of DUB is an imbalance in the sex hormones. During puberty or when entering menopause, women can have imbalanced hormone levels for months or even years. This causes sporadic bleeding, heavy bleeding, and spotting.