Menopause HRT

Question 1

What would you prescribe for a woman commencing systemic HRT with an intact uterus?

Answer 1

Transdermal E patch plus Mirena or oral P:

• Estradiol (brand name Estradot) patch 25 mcg/24 hrs
• MPA (brand name Provera) 5 mg daily
• NET 1.25 mg daily, micronised progesterone (brand name Utrogestan) 100 mg daily.

Oral E plus oral P or Mirena:

• Estradiol (brand name Progynova) 1 mg
• Ethinylestradiol 10 mcg daily

Tibolone

E plus SERM

Question 2

What would you prescribe for a woman commencing systemic HRT who has had a hysterectomy?

Answer 2

Transdermal E patch:
- Estradiol (brand name Estradot) patch 25 mcg/24 hrs

Oral E:

• Estradiol (brand name Progynova) 1 mg daily
• Ethinylestradiol 10 mcg daily